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Categories: Archaeology: General, Biology: Developmental

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A research consortium provides evidence that social behavior and social status are reflected at the molecular level of gene activation (epigenome) in juvenile and adult free-ranging spotted hyenas. They analyzed non-invasively collected gut epithelium samples from both high-ranking and low-ranking female hyenas and showed that rank differences were associated with epigenetic signatures of social inequality, i.e., the pattern of activation or switching off of genes that regulate important physiological processes such as energy conversion and immune response in several genome regions.

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Biologists have uncovered a quality control timing mechanism tied to cell division. The 'stopwatch' function keeps track of mitosis and acts as a protective measure when the process takes too long, preventing the formation of cancerous cells.

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What did an ancient Chinese emperor from 1,500 years ago look like? A team of researchers reconstructed the face of Chinese Emperor Wu of Northern Zhou using DNA extracted from his remains. The study suggests the emperor's death at the age of 36 might be linked to a stroke. It also sheds light on the origin and migration patterns of a nomadic empire that once ruled parts of northeastern Asia.

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Branching patterns are prevalent in our natural environment and the human body, such as in the lungs and kidneys. For example, specific genes that express growth factor proteins are known to influence the development of the lungs' complex branches. Researchers have unveiled a regulatory system linking signal, force, and shape in mouse lung structure development. The team recognized that the signal protein ERK plays an active role in causing growing lung tissue to curve.

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Those with aging immune systems struggle to fight off novel viruses and respond weakly to vaccination. Researchers were able to revitalize the immune system in mice.

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GPT-4 can accurately interpret types of cells important for the analysis of single-cell RNA sequencing -- a sequencing process fundamental to interpreting cell types -- with high consistency compared to that of time-consuming manual annotation by human experts of gene information.

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For centuries, the Cerne Giant, a figure carved into a hillside in Dorset, has fascinated locals and visitors to the area. A new paper proposes that the Cerne Giant can in fact be dated to the early Middle Ages, and, as a result, its cultural context and significance more clearly understood.

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A new study combining genetic, palaeoecological, and archaeological evidence has unveiled the Persian Plateau as a pivotal geographic location serving as a hub for Homo sapiens during the early stages of their migration out of Africa. It highlights the period between 70,000 to 45,000 years ago when human populations did not uniformly spread across Eurasia, leaving a gap in our understanding of their whereabouts during this time frame.

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A team of archaeologists discovered tiny microplastic particles in deposits located more than seven meters deep, in samples dating back to the first or early second century and excavated in the late 1980s.

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Archaeological analysis of a near unique animal cemetery discovered in London nearly 30 years ago has revealed there was an international horse trading network, orchestrated by the elites of late medieval and Tudor England, which brought superior physical specimens to the UK for jousting and for use as status symbols.

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Aging may be less about specific 'aging genes' and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers. A decline in the expression of long genes with age has been observed in a wide range of animals, from worms to humans, in various human cell and tissue types, and also in individuals with neurodegenerative disease. Mouse experiments show that the phenomenon can be mitigated via known anti-aging factors, including dietary restriction.

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Scientists have uncovered the fossilized skull of a 270-million-year-old ancient amphibian ancestor in the collection of the Smithsonian's National Museum of Natural History. The team of researchers described the fossil as a new species of proto-amphibian, which they named Kermitops gratus in honor of the iconic Muppet, Kermit the Frog.

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New research finds a direct communication path between the lungs and the brain which may change the way we treat respiratory infections and chronic conditions. The lungs are using the same sensors and neurons in the pain pathway to let the brain know there's an infection. The brain then prompts the symptoms associated with sickness. Findings indicate we may have to treat the nervous system as well as the infection.

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Detailed reports on thousands of artifacts pulled from 'Britain's Pompeii' reveals the surprisingly sophisticated domestic lives of Bronze Age Fen folk some 3,000 years ago -- from home interiors to recipes, clothing, kitchenware and pets.

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A new study has challenged previously held views that brain preservation in the archaeological record is extremely rare. The team compiled a new archive of preserved human brains, which highlighted that nervous tissues actually persist in much greater abundances than traditionally thought, assisted by conditions that prevent decay.

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Biologists have published a chromosomally assembled reference genome for the European brown hare. The genome consists of 2.9 billion base pairs, which form 23 autosomal chromosomes, and X and Y sex chromosomes. The timing of the genome release is very appropriate as the brown hare also represents the original Easter Bunny familiar from European folklore.

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Some soil bacteria can acquire sets of genes that enable them to pump the heavy metal nickel out of their systems, a study has found. This enables the bacteria to not only thrive in otherwise toxic soils but help plants grow there as well. A research team pinpointed a set of genes in wild soil bacteria that allows them to do this in serpentine soils which have naturally high concentrations of toxic nickel. The genetic discovery could help inform future bioremediation efforts that seek to return plants to polluted soils.

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The curvature of a surface determines the migration behavior of biological cells. They preferentially move along valleys or grooves while avoiding ridges. These findings gave rise to a model predicting cellular behavior. Such universal principles now allow a better understanding of the migration of immune and cancer cells, paving the way for new treatment options.

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Making a personalized T cell therapy for cancer patients currently takes at least six months. Scientists have shown that the laborious first step of identifying tumor-reactive T cell receptors for patients can be replaced with a machine learning classifier that halves this time.

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In examining the mating rituals of roundworms, researchers uncovered a unique approach to reproduction that maximizes genetic fitness.