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Categories: Biology: Developmental, Paleontology: General

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During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into lung-resident memory B cells, or lung-BRMs, that are critical for pulmonary immunity. These long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes and reside there permanently as the first layer of defense that can quickly react to produce antibodies in a future infection.

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HIV anti-retroviral therapy is considered a treatment and not a cure because patients usually carry a reservoir of HIV-infected cells that can re-emerge if treatment stops. These reservoirs have long been thought to be dormant, but two independent groups of researchers report that a subset of these cells spontaneously produce HIV RNA and proteins that may impact patients' HIV-specific immune responses.

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A new study by researchers from the University of Bath (UK) and Universidad Nacional Autónoma de México (Mexico) shows that flowering plants escaped relatively unscathed from the mass extinction that killed the dinosaurs 66 million years ago. Whilst they suffered some species loss, the devastating event helped flowering plants become the dominant type of plant today.

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Root hairs represent a low-cost strategy to enhance nutrient uptake because they can significantly increase the nutrient-acquiring surface of plant roots. While primary and lateral roots are stimulated to elongate when plants grow under mild nitrogen deficiency, the existence of such a foraging response for root hairs and its underlying regulatory mechanism remain elusive. Now, researchers have revealed a framework composed of specific molecular players meditating auxin synthesis, transport and signaling that triggers root hair elongation for nitrogen acquisition.

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Researchers have unveiled an intriguing phenomenon of cellular reprogramming in mature adult organs, shedding light on a novel mechanism of adaptive growth. The study, which was conducted on fruit flies (Drosophila), provides further insights into dedifferentiation -- where specialized cells that have specific functions transform into less specialized, undifferentiated cells like stem cells.

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Researchers have developed a new imaging technique to observe active gene expression in real time. They found that four molecules work together to control the timing of each stage of the C. elegans worm's development. This timekeeping process could provide important clues about the natural rhythm of development in humans and other animals.

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Researchers have successfully created chimeric embryos containing a combination of human and pig cells. When transferred into surrogate pig mothers, the developing humanized kidneys had normal structure and tubule formation after 28 days. This is the first time that scientists have been able to grow a solid humanized organ inside another species, though previous studies have used similar methods to generate human tissues such as blood or skeletal muscle in pigs.

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Genetic manipulation of a puzzling, miniscule bacteria that has lived in human mouths at least since the Middle Stone Age is elucidating the genes needed for its unusual lifestyle. These Patescibacteria in the human oral microbiome reside on the surface of another, larger host microbe. Found in many water and land environments, Patescibacteria in general lack the genes required to make many molecules necessary for life, such as the amino acids that make up proteins, the fatty acids that form membranes, and the nucleotides in DNA. This has led researchers to speculate that many of them rely on other bacteria to grow. In a new study, researchers present the first glimpse into the molecular mechanisms behind their relationship with their host cells. They also share details gleaned from fluorescent, time-lapse microsopic imaging of these bacteria as they bud and send out swarms of tiny progeny, only a fraction of which are able to establish a host relationship.

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Scientists have identified a key part of a mechanism that annotates genetic information before it is passed from fathers to their offspring. The findings shed new light on genomic imprinting, a fundamental, biological process in which a gene from one parent is switched off while the copy from the other parent remains active. Errors in imprinting are linked to a host of diseases, such as the rare disease Silver-Russell syndrome along with certain cancers and diabetes.

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Biomedical scientists have confirmed that newly discovered cells in the thymus are just like M cells, which are mostly known for their presence in the intestinal epithelium.

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A team of researchers has revealed that the Dumpy protein, a component of extracellular matrices -- or ECM -- is the key factor in regulating the stereotypic origami-like folding of wing-cell sheets. Their findings that wing cells never divide during folding nor do they exhibit spatially distinct behaviors suggest how external cues can create consistent 3D tissue structures.

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Right at the bottom of the deep sea, the first very simple forms of life on earth probably emerged a long time ago. Today, the deep sea is known for its bizarre fauna. Intensive research is being conducted into how the number of species living on the sea floor have changed in the meantime. Some theories say that the ecosystems of the deep sea have emerged again and again after multiple mass extinctions and oceanic upheavals. Today's life in the deep sea would thus be comparatively young in the history of the Earth. But there is increasing evidence that parts of this world are much older than previously thought.

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A new study has uncovered intriguing insights into the evolution of plant biology, effectively rewriting the history of how they evolved over the past billion years.

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When fighting disease, our immune cells need to reach their target quickly. Researchers have now discovered that immune cells actively generate their own guidance system to navigate through complex environments. This challenges earlier notions about these movements. The researchers' findings enhance our knowledge of the immune system and offer potential new approaches to improve human immune response.

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In a new study, researchers used mice to understand how DiNP affects pregnancy.

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An international team of marine scientists has studied the DNA of family groups from four different whale species to estimate their mutation rates. Using the newly determined rates, the group found that the number of humpback whales in the North Atlantic before whaling was 86 percent lower than earlier studies suggested.

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A new study brings together intriguing details about the little-known Rhabdodontidae dinosaurs of Late Cretaceous Europe. These gregarious herbivores, characterized by robust builds and beaks specialized for tough vegetation, inhabited the European archipelago. Despite being widespread and abundant, they vanished in Western Europe due to environmental changes around 69 million years ago, while surviving longer in Eastern Europe. Their fossil record offers valuable insights into their evolution and lifestyle, although its limited nature still challenges comprehensive understanding.

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Scientists use cutting edge scanning technology to reconstruct 'fossil monster' that lived half a billion years ago. The creature's soft anatomy was well-preserved, allowing it to be imaged almost completely: It fills a gap in our understanding of the evolution of arthropods such as insects and crustaceans.

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Findings can open up new avenues for targeted approaches toward therapeutic strategies against the malaria-causing P. falciparum that are aimed at stopping the parasite's life cycle progression and its sexual differentiation, thus blocking the transmission of the parasite into mosquitoes.

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A new article describes the 266 fossil species as one of the richest and most diverse groups of three-million-year-old fauna ever found in New Zealand. At least ten previously unknown species will be described and named in future research. Fossils of the world's oldest known flax snails, an extinct sawshark spine, and great white shark teeth have all been found in a mound of sand excavated from beneath Mangere Wastewater Treatment Plant in 2020.