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Categories: Biology: Developmental, Paleontology: General

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Researchers have developed and demonstrated a new method for high-throughput single-cell sorting that uses stimulated Raman spectroscopy rather than the traditional approach of fluorescence-activated cell sorting. The new approach could offer a label-free, nondestructive way to sort cells for a variety of applications, including microbiology, cancer detection and cell therapy.

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The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.

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A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression.

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Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.

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Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.

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Researchers have discovered the fossils of two new abelisaurs in Morocco, showing the diversity of dinosaurs in this region at the end of the Cretaceous period.

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Regulatory genes -- genes that control how other genes are used -- are responsible for 69% of the heritability of dairy cattle traits such as milk production and fertility, according to a new study. This contribution is 44% more than expected and much higher than previous studies of regulatory genes in humans. The findings, reported by a team of animal and human geneticists, could improve the efficiency of agricultural breeding programs. The study also helps solve the longstanding mystery of why mammalian genomes contain so much noncoding DNA.

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Researchers model and map how neurons across the tiny brain of a C. elegans worm encode its behaviors, revealing many new insights about the robustness and flexibility of its nervous system.

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Genetic remnants of viruses that are naturally present in the human genome could affect the development of neurodegenerative diseases. Researchers come to this conclusion on the basis of studies on cell cultures.

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Radiocarbon dating on bones in the La Brea Tar Pits lead archaeologists to warn that history may be repeating itself.

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An extremely rare collection of 160-million-year-old sea spider fossils from Southern France are closely related to living species, unlike older fossils of their kind.

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Can you recognize an old friend, but forget what you had for breakfast yesterday? Our brains constantly rearrange their circuitry to retain information, but the molecular basis behind this process isn't well understood. New research suggests that complex sugars called glycosaminoglycans might play a major role in the 'plasticity' of the brains of mice and could be used to repair neural connections after injury.

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A new method allows large quantities of muscle stem cells to be safely obtained in cell culture. This provides a potential for treating patients with muscle diseases -- and for those who would like to eat meat, but don't want to kill animals.

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The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, according to a new study.

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Researchers have developed a new algorithm for recovering the 3D refractive index distribution of biological samples that exhibit multiple types of light scattering.

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Scientists have discovered and documented the largest known single dinosaur track site in Alaska. The site, located in Denali National Park and Preserve, has been dubbed 'The Coliseum' by researchers.

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Recent paleogenomic research revealed that interbreeding was common among early human species. However, little was known about when, where, and how often this hominin interbreeding took place. Using paleoanthropological evidence, genetic data, and supercomputer simulations of past climate, a team of international researchers has found that interglacial climates and corresponding shifts in vegetation created common habitats for Neanderthals and Denisovans, increasing their chances for interbreeding and gene flow in parts of Europe and central Asia.

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A mathematical model provides new insights into the distribution of genetic information during bacterial cell division

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With 350 million years of evolution culminating in almost two centuries of scientific discourse, a new hypothesis emerges. Researchers propose a new explanation for why ammonoids evolved a highly elaborate, fractal-like geometry within their shells. Their analysis shows that the increasing complexity of shell structures provided a distinct advantage by offering improved protection against predators.

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An international research team details changes in DNA that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits.