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Categories: Biology: Developmental, Chemistry: General
Published New deep learning model is 'game changer' for measuring embryo development



A new deep learning model performs a task that biologists have struggled with for centuries -- how to measure the incredibly complex process of embryonic development. Scientists have shown that the AI model, known as Dev-ResNet, can identify what happens and when during embryonic development, from video. While used in pond snail embryos for this study, in future the technique could be used to help accelerate understanding on how climate change, and other external factors, affect humans and animals in the earliest stages of life.
Published Mechanisms for selective multiple sclerosis treatment strategy



Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.
Published 'The magic of making electricity from metals and air' The vexing carbonate has achieved it!



Team develops a high-energy, high-efficiency all-solid-state Na-air battery platform.
Published Genetic mosaicism more common than thought



Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of genomes in single cells that are too difficult to detect with other methods.
Published Researchers have unveiled a new method to manipulate cell movement in embryos



Scientists have developed a new method that can manipulate the movement of embryonic cells using short-time attractors.
Published How killifish embryos use suspended animation to survive over 8 months of drought



The African turquoise killifish lives in ephemeral ponds in Zimbabwe and Mozambique. To survive the annual dry season, the fish's embryos enter a state of extreme suspended animation or 'diapause' for approximately 8 months. Now, researchers have uncovered the mechanisms that enabled the killifish to evolve this extreme survival state.
Published Investigating the origin of circatidal rhythms in freshwater snails



While most organisms have biological clocks synchronized with the day-night cycle (circadian rhythms), marine animals in tidal areas have also developed circatidal rhythms to align with the tidal cycle. Comparing the activity and genetic expression of snails from tidal and non-tidal areas, researchers demonstrate that circatidal rhythms develop as snails adapt to tidal environments. These findings highlight the flexibility of biological clocks, enabling organisms to adjust their rhythms according to the environment.
Published Charge your laptop in a minute or your EV in 10? Supercapacitors can help



Imagine if your dead laptop or phone could charge in a minute or if an electric car could be fully powered in 10 minutes. New research could lead to such advances.
Published Controlling water, transforming greenhouse gases



Researchers have outlined a way to manipulate water molecules to make CO2R more efficient, with the ultimate goal of creating a clean energy loop. Through their new method, the team was able to perform CO2R with nearly 100% efficiency under mildly acidic conditions, using either gold or zinc as catalysts.
Published Observing mammalian cells with superfast soft X-rays



Researchers have developed a new technique to view living mammalian cells. The team used a powerful laser, called a soft X-ray free electron laser, to emit ultrafast pulses of illumination at the speed of femtoseconds, or quadrillionths of a second. With this they could capture images of carbon-based structures in living cells for the first time, before the soft X-ray radiation damaged them.
Published New 'atlas' provides unprecedented insights on how genes function in early embryo development



Biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new 'gene atlas' with 4-D imaging, the researchers captured unprecedented insights on how embryonic development unfolds.
Published Charting a pathway to next-gen biofuels



From soil to sequestration, researchers have modeled what a supply chain for second-generation biofuels might look like in the midwestern United States.
Published Birdsong and human voice built from same genetic blueprint



Humans have been long fascinated by bird song and the cacophony of other avian sounds -- from coos and honks to quacks and peeps. But little is known about how the unique vocal organ of birds -- the syrinx -- varies from species to species or its deeper evolutionary origins. A trio of recent studies is changing that. The studies include high-resolution anatomical scans of syrinxes from hummingbirds and ostriches -- the world's smallest and largest bird species -- and the discovery that the syrinx and larynx, the vocal organ of reptiles and mammals, including humans, share the same developmental programming.
Published Iron could be key to less expensive, greener lithium-ion batteries, research finds



Chemistry researchers are hoping to spark a green battery revolution by showing that iron instead of cobalt and nickel can be used as a cathode material in lithium-ion batteries.
Published New milestone for lithium metal batteries



Scientists develop a porous structures for lithium metal batteries.
Published Shedding light on the chemical enigma of sulfur trioxide in the atmosphere



Researchers discovered that sulfur trioxide can form products other than sulfuric acid in the atmosphere by interacting with organic and inorganic acids. These previously uncharacterized acid sulfuric anhydride products are almost certainly key contributors to atmospheric new particle formation and a way to efficiently incorporate carboxylic acids into atmospheric nanoparticles. Better prediction of aerosol formation can help curb air pollution and reduce uncertainties concerning climate change.
Published Novel approach to interrogate tissue-specific protein-protein interactions



Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery. However, our current understanding of such protein-protein interactions often lacks cellular contexts because they were usually studied in an in vitro system or in cells isolated from their tissue environment. Effective methods to investigate protein-protein interactions in a tissue-specific manner are largely missing.
Published Producing novel liquid crystals by stacking antiaromatic units



In a recent study, researchers developed modified norcorrole molecules whose side chains favored the formation of columnar -stacking structures. Using these compounds, they produced liquid crystals with high electrical conductivity and thermotropic properties. Their findings open up new design avenues for materials useful in electronics, sensing, optics, and biomedicine.
Published Unlocking complex sulfur molecules: Novel approach for synthesis of functionalized benzenethiol equivalents



Organosulfur skeletons are crucial in many fields, including pharmaceuticals and electronics. Synthesizing organosulfur skeletons requires o-bromobenzenethiols. However, conventional methods face challenges due to quick oxidation and formation of highly reactive intermediates. Researchers have now developed a new method for synthesizing o-bromobenzenethiols from aryne intermediates via bromothiolation. This method can pave the way for the synthesis of new organosulfur compounds with applications in diverse fields.
Published Tracking down the genetic causes of lupus to personalize treatment



Treatment of autoimmune diseases like lupus has long relied on steroids to knock down the immune system, but more targeted therapies are currently undergoing clinical trials. To make sure these therapies get to the patients who will benefit, work is needed to identify the specific mutations behind each patient's disease. Researchers now report several dozen mutations associated with oversensitive toll-like receptors -- a major cause of autoimmune disease -- and linked two mutations to patients.