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Categories: Biology: Developmental, Offbeat: Space
Published From hagfish to membrane: Modeling age-related macular degeneration
(via sciencedaily.com) Original source Researchers have successfully demonstrated that hagfish slime proteins can accurately replicate membranes in the human eye. Scientists were able to properly grow retinal cells on hagfish slime proteins and prove that the protein's behavior changes as the membrane mimics stages of aging and disease.
Published Flu: Interferon-gamma from T follicular helper cells is required to create lung-resident memory B cells
(via sciencedaily.com) Original source During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into lung-resident memory B cells, or lung-BRMs, that are critical for pulmonary immunity. These long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes and reside there permanently as the first layer of defense that can quickly react to produce antibodies in a future infection.
Published 'Dormant' HIV produces RNA and proteins during anti-retroviral therapy
(via sciencedaily.com) Original source HIV anti-retroviral therapy is considered a treatment and not a cure because patients usually carry a reservoir of HIV-infected cells that can re-emerge if treatment stops. These reservoirs have long been thought to be dormant, but two independent groups of researchers report that a subset of these cells spontaneously produce HIV RNA and proteins that may impact patients' HIV-specific immune responses.
Published Discovery of two potential Polar Ring galaxies suggests these stunning rare clusters might be more common than previously believed
(via sciencedaily.com) These new detections suggest polar ring galaxies might be more common than previously believed.
Published Auxin signaling pathway controls root hair formation for nitrogen uptake
(via sciencedaily.com) Original source Root hairs represent a low-cost strategy to enhance nutrient uptake because they can significantly increase the nutrient-acquiring surface of plant roots. While primary and lateral roots are stimulated to elongate when plants grow under mild nitrogen deficiency, the existence of such a foraging response for root hairs and its underlying regulatory mechanism remain elusive. Now, researchers have revealed a framework composed of specific molecular players meditating auxin synthesis, transport and signaling that triggers root hair elongation for nitrogen acquisition.
Published Water world? Methane, carbon dioxide in atmosphere of massive exoplanet
(via sciencedaily.com) A new investigation with NASA's James Webb Space Telescope into K2-18 b, an exoplanet 8.6 times as massive as Earth, has revealed the presence of carbon-bearing molecules including methane and carbon dioxide. Webb's discovery adds to recent studies suggesting that K2-18 b could be a Hycean exoplanet, one which has the potential to possess a hydrogen-rich atmosphere and a water ocean-covered surface.
Published Nutrients drive cellular reprogramming in the intestine
(via sciencedaily.com) Original source Researchers have unveiled an intriguing phenomenon of cellular reprogramming in mature adult organs, shedding light on a novel mechanism of adaptive growth. The study, which was conducted on fruit flies (Drosophila), provides further insights into dedifferentiation -- where specialized cells that have specific functions transform into less specialized, undifferentiated cells like stem cells.
Published These worms have rhythm
(via sciencedaily.com) Original source Researchers have developed a new imaging technique to observe active gene expression in real time. They found that four molecules work together to control the timing of each stage of the C. elegans worm's development. This timekeeping process could provide important clues about the natural rhythm of development in humans and other animals.
Published Study hints at the existence of the closest black holes to Earth in the Hyades star cluster
(via sciencedaily.com) A new article hints at the existence of several black holes in the Hyades cluster -- the closest open cluster to our solar system -- which would make them the closest black holes to Earth ever detected.
Published Researchers grow embryonic humanized kidneys inside pigs for 28 days
(via sciencedaily.com) Original source Researchers have successfully created chimeric embryos containing a combination of human and pig cells. When transferred into surrogate pig mothers, the developing humanized kidneys had normal structure and tubule formation after 28 days. This is the first time that scientists have been able to grow a solid humanized organ inside another species, though previous studies have used similar methods to generate human tissues such as blood or skeletal muscle in pigs.
Published Ravenous black hole consumes three Earths'-worth of star every time it passes
(via sciencedaily.com) Massive burst of X-rays detected by astronomers indicates material three times the mass of Earth burning up in a black hole. They observed a star like our own Sun being eaten away every time it orbits close. First time a Sun-like star being repeatedly disrupted by a low mass black hole has been seen, opening the possibility of a range of star and black hole combinations to be discovered.
Published Genetic tools probe microbial dark matter
(via sciencedaily.com) Original source Genetic manipulation of a puzzling, miniscule bacteria that has lived in human mouths at least since the Middle Stone Age is elucidating the genes needed for its unusual lifestyle. These Patescibacteria in the human oral microbiome reside on the surface of another, larger host microbe. Found in many water and land environments, Patescibacteria in general lack the genes required to make many molecules necessary for life, such as the amino acids that make up proteins, the fatty acids that form membranes, and the nucleotides in DNA. This has led researchers to speculate that many of them rely on other bacteria to grow. In a new study, researchers present the first glimpse into the molecular mechanisms behind their relationship with their host cells. They also share details gleaned from fluorescent, time-lapse microsopic imaging of these bacteria as they bud and send out swarms of tiny progeny, only a fraction of which are able to establish a host relationship.
Published Study illuminates mechanism that annotates genetic information passed from fathers to offspring
(via sciencedaily.com) Original source Scientists have identified a key part of a mechanism that annotates genetic information before it is passed from fathers to their offspring. The findings shed new light on genomic imprinting, a fundamental, biological process in which a gene from one parent is switched off while the copy from the other parent remains active. Errors in imprinting are linked to a host of diseases, such as the rare disease Silver-Russell syndrome along with certain cancers and diabetes.
Published Discovery of new cell type in thymus
(via sciencedaily.com) Original source Biomedical scientists have confirmed that newly discovered cells in the thymus are just like M cells, which are mostly known for their presence in the intestinal epithelium.
Published Unveiling the mechanism of 3D folding of cell sheets
(via sciencedaily.com) Original source A team of researchers has revealed that the Dumpy protein, a component of extracellular matrices -- or ECM -- is the key factor in regulating the stereotypic origami-like folding of wing-cell sheets. Their findings that wing cells never divide during folding nor do they exhibit spatially distinct behaviors suggest how external cues can create consistent 3D tissue structures.
Published Vast bubble of galaxies discovered, given Hawaiian name
(via sciencedaily.com) Original source The immense bubble is 820 million light years from Earth and believed to be a fossil-like remnant of the birth of the universe.
Published Immune cells shape their own path
(via sciencedaily.com) Original source When fighting disease, our immune cells need to reach their target quickly. Researchers have now discovered that immune cells actively generate their own guidance system to navigate through complex environments. This challenges earlier notions about these movements. The researchers' findings enhance our knowledge of the immune system and offer potential new approaches to improve human immune response.
Published Di-isononyl phthalate disrupts pregnancy in mice, study finds
(via sciencedaily.com) Original source In a new study, researchers used mice to understand how DiNP affects pregnancy.
Published Webb reveals new structures within iconic supernova
(via sciencedaily.com) NASA's James Webb Space Telescope has begun the study of one of the most renowned supernovae, SN 1987A (Supernova 1987A). Located 168,000 light-years away in the Large Magellanic Cloud, SN 1987A has been a target of intense observations at wavelengths ranging from gamma rays to radio for nearly 40 years, since its discovery in February of 1987. New observations by Webb's NIRCam (Near-Infrared Camera) provide a crucial clue to our understanding of how a supernova develops over time to shape its remnant.
Published Scientists detect and validate the longest-period exoplanet found with TESS
(via sciencedaily.com) Scientists have detected and validated two of the longest-period exoplanets found by TESS to date. These long period large exoplanets orbit a K dwarf star and belong to a class of planets known as warm Jupiters, which have orbital periods of 10-200 days and are at least six times Earth's radius. This recent discovery offers exciting research opportunities for the future of finding long-period planets that resemble those in our own solar system.