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Categories: Biology: Developmental, Offbeat: Paleontology and Archeology

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A recent study led to the development of a powerful epigenetic editing technology. The system unlocks the ability to precisely program chromatin modifications at any specific position in the genome, to understand their causal role in transcription regulation. This innovative approach will help to investigate the role of chromatin modifications in many biological processes, and to program desired gene activity responses, which may prove useful in disease settings.

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A new computational model simulating fruit fly wing development has enabled researchers to identify previously hidden mechanisms behind organ generation. An research team developed a fruit fly model to reverse engineer the mechanisms that generate organ tissue.

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Researchers have found that herpesvirus infection modifies the structure and normal function of the mitochondria in the host cell. The new information will help to understand the interaction between herpesvirus and host cells. Knowledge can be utilized in the development of viral treatments.

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The earliest stages of mammalian embryo development are like an orchestra performance, where everyone must play at the exact right moment and in perfect harmony. New research identifies one of the conductors making sense of the chaos.

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In research that may be a step forward toward finding personalized treatments for Tourette disorder, scientists have bred mice that exhibit some of the same behaviors and brain abnormalities seen in humans with the disorder.

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Land plants cover the surface of our planet and often tower over us. They form complex bodies with multiple organs that consist of a broad range of cell types. Developing this morphological complexity is underpinned by intricate networks of genes, whose coordinated action shapes plant bodies through various molecular mechanisms. All of these magnificent forms burst forth from a one-off evolutionary event: when plants conquered Earth's surface, known as plant terrestrialization.

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Researchers uncovered compelling evidence that Earth's magnetic field was in a highly unusual state when the macroscopic animals of the Ediacaran Period -- 635 to 541 million years ago -- diversified and thrived. Their study raises the question of whether these fluctuations in Earth's ancient magnetic field led to shifts in oxygen levels that may have been crucial to the proliferation of life forms millions of years ago.

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Researchers have discovered that how a special protein complex called the Mediator moves along genes in DNA may have an impact on how cells divide. The discovery may be important for future research into the treatment of certain diseases.

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Working with human breast and lung cells, scientists say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times, a hallmark of cancer cells.

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Natural malaria infections have been genetically analysed at a higher resolution than ever before, giving insights that could help understand and block transmission.

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A new documentary has recreated the face of a 75,000-year-old female Neanderthal whose flattened skull was discovered and rebuilt from hundreds of bone fragments by a team of archaeologists and conservators.

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Scientists are harnessing cells to make new types of materials that can grow, repair themselves and even respond to their environment. These solid 'engineered living materials' are made by embedding cells in an inanimate matrix that's formed in a desired shape. Now, researchers have 3D printed a bioink containing plant cells that were then genetically modified, producing programmable materials. Applications could someday include biomanufacturing and sustainable construction.

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Conventional plant regeneration approaches by cell culture require the external application of plant growth regulators, including hormones. However, optimizing culture conditions can be laborious. Now, researchers have developed a novel plant regeneration system that omits the need for hormone application by genetically regulating the expression of genes that control plant cell differentiation. Their work holds significant potential in the development of genetically modified plants in a simpler and cost-effective manner.

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Scientists report significant progress in cultivating nephron progenitor cells (NPCs), the cells destined to form the kidney's filtration system, the nephrons. NPCs hold immense promise for understanding kidney development, modeling diseases, and discovering new treatments. The team improved the chemical cocktail for generating and growing NPCs in the laboratory, enabling the sustained growth of both mouse and human NPCs in a simple 2-dimensional format.

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How did North America's saber-toothed cats hunt without breaking their unwieldy saber-like canines, which are vulnerable to sideways bending stresses? A paleontologist provides mechanical evidence that during adolescence, when young cats were learning to hunt, their baby teeth remained in place for up to 30 months to laterally buttress the emerging permanent sabers. By the time the baby teeth fell out, presumably the adult cat knew how to protect its sabers during attacks.

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The research explores how CRISPR can be used to edit RNA.

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Dinosaurs were likely as smart as reptiles but not as intelligent as monkeys.

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Using environmental DNA analysis, an international team of researchers identified a collection of plants used in ceremonial rituals in the ancient Maya city of Yaxnohcah in Mexico. The plants, known for their religious associations and medicinal properties, were discovered beneath a plaza floor where a ballcourt was built.

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Mice lacking an olfactory system have had their sense of smell restored with neurons from rats, the first time scientists have successfully integrated the sensory apparatus of one species into another.

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Researchers have developed a web-based platform that offers an unprecedented view of the human body at the cellular level. The aim is to create an invaluable resource for researchers worldwide to increase knowledge about human health and disease.