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Categories: Biology: Biochemistry, Chemistry: Organic Chemistry

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Researchers have shown how and why the depletion of microbes in a newborn's gut by antibiotics can lead to lifelong respiratory allergies. The research team identified a specific cascade of events that lead to allergies and asthma, opening many new avenues for exploring potential preventions and treatments.

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Large-scale genomic analysis of darkling beetles, a hyper-diverse insect group of more than 30,000 species worldwide, rolls back the curtain on a 150-million-year evolutionary tale of one of Earth's most ecologically important yet inconspicuous creatures, according to new research.

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Researchers have discovered RNA mechanisms that may lead to more effective, durable and targeted treatments for conditions like high cholesterol, liver diseases and cancers.

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Scientists are finding clues for how to treat diabetes and hormone disorders in an unexpected place: a toxin from one of the most venomous animals on the planet.

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Machine learning models have become increasingly popular for risk assessment of chemical compounds. However, they are often considered 'black boxes' due to their lack of transparency. To increase confidence in these models, researchers proposed carefully identifying the areas of chemical space where these models are weak. They developed an innovative software tool for this purpose, and the results of this research approach have just been published.

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Researchers develop a one pot process to transform aromatic ketones to esters, offering advancements in pharmaceutical synthesis and materials science.

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Scientists have developed photoresponsive supramolecular polymers that can undergo both intrachain folding and interchain aggregation.

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A new adaptive 3D printing system can identify the positions of randomly distributed organisms and safely move them to specific locations for assembly.

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A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA. The research could reshape scientists' understanding of gene regulation and how genetic variations may influence gene expression in development or disease.

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Researchers have identified the genetic changes linked to why plants go through a developmental change similar to 'puberty' at different rates, a discovery which could lead to better crop nutrition.

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Researchers have made a significant discovery about how the gut microbiome interacts with cells to cause cardiovascular disease. The study found phenylacetylglutamine (PAG), produced by gut bacteria as a waste product, then absorbed and formed in the liver, interacts with previously undiscovered locations on beta-2 adrenergic receptors on heart cells once it enters the circulation.

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If you've visited a trendy cafe in the past few years, you might have noticed 'golden' turmeric milk on the menu. This fancy drink is caffeine-free, coffee-free and can even be vegan. And now, researchers have developed an efficient method to make a powdered, plant-based, instant version that maintains the beneficial properties of the ingredients while also extending its shelf life.

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Artificial intelligence (AI) has exploded in popularity as of late. But just like a human, it's hard to read an AI model's mind. Explainable AI (XAI) could help us do just that by providing justification for a model's decisions. And now, researchers are using XAI to scrutinize predictive AI models more closely, which could help make better antibiotics.

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As the world faces the challenges of mitigating climate change and providing resources for a growing population, there is increasing focus on developing circular economies for sustainable production. But to evaluate strategies and impacts, it is necessary to have reliable metrics. Researchers have now developed a Circularity Index that provides a comprehensive method to quantify circularity in bioeconomic systems. In a new paper, they outline the method and apply it to two case studies -- a corn/soybean farming operation and the entire U.S. food and agriculture system.

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When a global pandemic forced previous a graduate student out of the lab and onto the computer, he found a world of difference hidden in the long-studied species of Botryoccocus braunii -- and discovered that it isn't one species at all, but three.

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A new article provides a narrative review of the relevant similarities and distinctions between nonhumans and humans to assess the causes and consequences of winner and loser effects in humans.

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The avian influenza virus needs to mutate to cross the species barrier and to infect and replicate within mammalian cells. Scientists have now deciphered the structure of the avian influenza virus's polymerase when it interacts with a human protein essential for the virus to replicate within the cell. The structure of this replication complex provides important information about the mutations that avian influenza polymerase must undergo to adapt to mammals, including humans. These results can help scientists monitor the evolution and adaptability of bird flu strains, such as H5N1 or H7N9, towards infecting other species.

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The sea anemone Nematostella vectensis is potentially immortal. Using molecular genetic methods, developmental biologists have now identified possible candidates for multipotent stem cells in the sea anemone for the first time. These stem cells are regulated by evolutionary highly conserved genes.

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A new animal study shows that exposure to immune-stimulating proteins left behind by COVID-19 leads to lower cortisol, brain inflammation and a heightened reaction to subsequent stressors.

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Circadian rhythms appear to influence vulnerability to malaria parasites.