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Categories: Biology: Biochemistry, Engineering: Graphene

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The Second Plague Pandemic of the mid-14th century, also known as the Black Death, killed 30-60 percent of the European population and profoundly changed the course of European history. New research suggests that this plague, potentially through resulting changes in diet and hygiene, may also be associated with a shift in the composition of the human oral microbiome toward one that contributes to chronic diseases in modern-day humans.  

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Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study identified the epigenetic regulator MSL2 an 'anti-monoallelic' factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes.

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New research identifies the class II PI3K-C2b protein, a member of the PI3 family of kinases, as one of the key regulators of blood vessels growth in humans and other mammals. Mutations in these family of proteins may lead to vascular malformations and the precise understanding of the whole process is instrumental in opening the door to new therapeutic approaches in the future.

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Fruit and vegetables contain a variety of plant natural products such as flavonoids, which give fruits their colour and are said to have health-promoting properties. Most plant natural products occur in nature as glycosides, i.e. chemical compounds with sugars. In order for humans to absorb the healthy plant natural products, the sugar must be split off in the intestine. Microorganisms in the intestinal flora help to speed up the process. So-called C-glycosides, i.e. plant natural products with a carbon-based bond to a sugar, would even be practically indigestible without the intestinal microbes (e.g. nothofagin in rooibos tea).

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Enzymes from microorganisms can produce hydrogen (H2) under certain conditions, which makes them potential biocatalysts for biobased H2 technologies. In order to make this hydrogen production efficient, researchers are trying to identify and eliminate possible limiting factors. These include formaldehyde, which occurs naturally as a metabolic product in cells and inhibits the particularly efficient [FeFe] hydrogenase.

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New research has provided a detailed examination of England's bottlenose dolphin population's existence and the challenges it faces from human activities and environmental factors on a daily basis.

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Bees, wasps and ants belong to the Hymenoptera order and inject a whole cocktail of venomous ingredients when they sting. Despite their tremendous ecological and economic importance, little was previously known about the origins of their venom. Through extensive genomic studies, a team of researchers has now discovered that typical venomous components were already present in the earliest ancestors of Hymenoptera and must therefore have evolved before the stingers of bees and other insects. What's more, and contrary to previous assumptions, the gene for the venom melittin is found solely in bees.

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A landmark study into the geological timescale distribution of sediment and nutrients over 500 million years shows that species biodiversity on Earth is driven by landscape dynamics.

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The evolution of higher cognitive functions in humans has so far mostly been linked to the expansion of the neocortex. Researchers are increasingly realizing, however, that the 'little brain' or cerebellum also expanded during evolution and probably contributes to the capacities unique to humans. A research team has now generated comprehensive genetic maps of the development of cells in the cerebella of human, mouse and opossum. Comparisons of these maps reveal both ancestral and species-specific cellular and molecular characteristics of cerebellum development.

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One in 200 newborns is admitted to a neonatal unit with sepsis caused by a bacteria commonly carried by their mothers -- much greater than the previous estimate, say researchers. The team has developed an ultra-sensitive test capable of better detecting the bacteria, as it is missed in the vast majority of cases.

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A new study found that alcohol consumption may have counteractive effects on CVD risk, depending on the biological presence of certain circulating metabolites -- molecules that are produced during or after a substance is metabolized and studied as biomarkers of many diseases. The researchers observed a total of 60 alcohol consumption-related metabolites, identifying seven circulating metabolites that link long-term moderate alcohol consumption with an increased risk of CVD, and three circulating metabolites that link this same drinking pattern with a lower risk of CVD.

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Extracellular vesicles were found to inhibit the viral infection of COVID-19 and potentially other infectious diseases.

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Scientists have unraveled the evolutionary journey of a unique type of photosynthesis that allows some bacteria to harness far-red light, a region beyond the visible spectrum. This discovery could pave the way for engineering plants with enhanced light absorption capabilities and has implications for our search for extraterrestrial life.

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Researchers have developed a way of joining up the head and tail of a protein, making it more stable and easier to get into cells.

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Researchers characterize nearly 600 microbial genomes collected from goldmine. The study illuminates 'microbial dark matter' residing below the surface. Microbes divide into two groups: minimalists that have one, specialized job or maximalists that are prepared to use any available resource. Study has implications for how underground activities, like mining and carbon storage, could affect or be affected by microbial life. The lifestyle of these 'intraterrestrial' microbes also provides hints to what organisms could be living on other planets.

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The slash-and-burn agriculture practiced by many Indigenous societies across the world can actually have a positive impact on forests, according to a new study done in Belize. Researchers found that in areas of the rainforest in which Indigenous farmers using slash-and-burn techniques created intermediate-sized farm patches -- neither too small nor too large -- there were increases in forest plant diversity.

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Researchers have developed a new surgical implant that has the potential to transform the treatment of complex bone infections. When implanted on an injured or infected bone, the material can not only speed up bone healing, it also reduces the risk of infections without the need for traditional antibiotics. 

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Scientists describe how they identified a molecule that may trigger over-consumption of comfort foods after a threatening event.

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Scientists have found both potential threats and promising resources in the thriving colonies of bacteria and fungi on plastic trash washed up on shores. 

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Nearly a third of the world's mine tailings are stored within or near protected conservation areas, new research has found.