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Categories: Biology: Biochemistry, Engineering: Graphene

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Researchers have discovered that the mere act of attaching their microparticle 'backpacks' to neutrophils is enough to activate them against cancer -- no drugs needed. In experiments, backpack-bearing neutrophils shrank tumors and extended the survival of mice with cancer, and treated animals retained an immune memory of the disease. This approach opens the door to a new class of drug-free immunotherapy for cancer.

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In a series of trials involving trained distance runners, researchers found that ingesting a cranberry supplement for 28 consecutive days led to noticeable improvements in both performance and muscle fatigue following 1,500-metre time trials. Reoxygenation rates were faster and running speeds improved by 1.5 per cent. The researchers found that 28 days of cranberry extract consumption by elite level endurance runners demonstrated a trend toward increased speed in 1,500-metre time trials but not in 400-metre ones. However, they did notice that lactate buildup was reduced following the 400-metre but not the 1,500-metre compared to baseline. The data also indicated that the cranberry extract promoted better oxygen extraction by the muscle, improved lactate clearance and slower muscle deoxygenation.

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Human sweat contains a protein that may protect against Lyme disease. About one-third of the population carries a genetic variant of this protein that is associated with Lyme disease in genome-wide association studies.

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To better understand a carbon sink in danger, scientists are turning to tiny organisms that have long been overlooked.

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Some soil bacteria can acquire sets of genes that enable them to pump the heavy metal nickel out of their systems, a study has found. This enables the bacteria to not only thrive in otherwise toxic soils but help plants grow there as well. A research team pinpointed a set of genes in wild soil bacteria that allows them to do this in serpentine soils which have naturally high concentrations of toxic nickel. The genetic discovery could help inform future bioremediation efforts that seek to return plants to polluted soils.

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Heparin, the world's most widely used blood thinner, is used during procedures ranging from kidney dialysis to open heart surgery. Currently, heparin is derived from pig intestines, but scientists have discovered how to make it in the lab. They have also developed a path to a biomanufacturing process that could potentially revolutionize how the world gets its supply of this crucial medicine.

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Researchers have used a series of artificial stream channels to mimic the behavior of headwater creeks under future climate change scenarios. They found that drier conditions shifted the life cycles of the algae and insects that form the base of the alpine food web. However, because species adjusted to the shifts in a variety of ways, the stream ecosystems were generally resilient to the changing conditions.

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Researchers have developed a strategy for using genomics to monitor for and identify emerging resistance to pesticides, helping farmers prolong the effectiveness of pest management tools.

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Our eating habits in industrialized societies are far removed from those of ancient humans. This is impacting our intestinal flora, it seems, as newly discovered cellulose degrading bacteria are being lost from the human gut microbiome, especially in industrial societies.

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Polyphenols, abundant in fruits, vegetables, tea, and coffee, offer potential health benefits. However, owing to low bioavailability, the mechanisms underlying their beneficial effects remain unknown. In a recent study, researchers have explored the interaction between polyphenols and human sensory receptors. Their findings elucidate how polyphenols influence brain function and metabolic pathways by interacting with gut receptors, explaining their role in well-being and nutrition innovation.

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The development of hair was of central importance for the evolution of mammals and thus also of humans. However, the evolutionary origin of the genetic program of hair was previously unknown. Researchers have now been able to show that important hair components and their genetic control have already evolved in amphibians. Human hair therefore shows unexpected similarities to the claws of clawed frogs.

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Scientists have discovered how female Diadem butterflies have evolved to look like African Queen butterflies to repel predators.

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Research is exploring how to add value to lignin by breaking it down into small molecules that are structurally similar to oxygenated hydrocarbons. These renewable chemicals are key components in many industrial processes and products, but they are traditionally sourced from non-renewable petroleum.

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The curvature of a surface determines the migration behavior of biological cells. They preferentially move along valleys or grooves while avoiding ridges. These findings gave rise to a model predicting cellular behavior. Such universal principles now allow a better understanding of the migration of immune and cancer cells, paving the way for new treatment options.

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Although prevention and treatment strategies are available for influenza, they are not sufficient for vulnerable populations such as young children and newborns. A team of researchers has studied newborn piglets to better understand the progression of influenza infections.

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In a first for the condensate field, researchers have figured out how nucleolar sub-structures are assembled. This organization gives rise to unique pH profiles within nucleoli, which they measured and compared with the pH of nearby non-nucleolar condensates including nuclear speckles and Cajal bodies.

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Eating fatty food in the days leading up to surgery may prompt a heightened inflammatory response in the brain that interferes for weeks with memory-related cognitive function in older adults -- and, new research in animals suggests, even in young adults.

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Research has demonstrated individual differences in and successfully extracted commonalities from the whole-brain activity of roundworms. The researchers also found that computer simulations based on the whole-brain activity of roundworms more accurately reflect real-brain activity when they include so-called 'noise,' or probabilistic elements.

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Investigators discovered that unique bacteria colonize the gut shortly after birth and make the neurotransmitter serotonin to educate gut immune cells. This prevents allergic reactions to food and the bacteria themselves during early development.

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Scientists tested several hypotheses on the drivers of social aging in free-living Assamese macaques in Thailand. The researchers collected data on the social behavior of females for eight years and found that the size of their social networks decreases with increasing age. The females continued to interact with their close social partners, but gradually withdrew from social interactions altogether. The results contribute to the understanding of the evolutionary origins of social aging.