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Categories: Biology: Biochemistry, Space: Structures and Features

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A team of researchers has developed a software tool that provides a way for the safer design of genome editing in all organisms with a transcriptome. For about a decade, researchers have used the CRISPR technology for genome editing. However, there are some challenges in the use of CRISPR. The new analysis system overcomes these challenges and allows researchers to perform safer on- and off-target assessments without a reference genome. It holds the potential for applications in medicine, agriculture, and biological research.

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Urban environments have become hotspots for understanding how rapid evolution occurs in response to extreme environmental changes. These habitats exert selective pressures on resident organisms that impact their evolutionary trajectories. Recently, researchers investigated how the creeping woodsorrel plant might adapt in response to elevated temperatures that result from urbanization. Understanding these effects can help predict evolutionary traits to manage plant evolution in the face of shifting climatic conditions.

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The fossils of a 170-million-year-old ancient marine reptile from the Age of Dinosaurs have been identified as the oldest-known mega-predatory pliosaur -- a group of ocean-dwelling reptiles closely related to the famous long-necked plesiosaurs. The findings are rare and add new knowledge to the evolution of plesiosaurs.

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The ability of Mycobacterium tuberculosis (MTB), a serious respiratory infection, to form snake-like cords was first noted nearly 80 years ago. Investigators report the biophysical mechanisms by which these cords form and demonstrate how several generations of dividing bacteria hang together to create these structures that enable resistance to antibiotics.

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Researchers are studying the dramatic physical transformation that some insects undergo to give birth to live young. This includes suppressing their immune systems to accommodate babies, which is something some insects and people have in common. Understanding how these systems work can help improve treatments for fibromyalgia and other immune disorders. An international team of researchers has examined the complex structural and physiological changes that take place in Hawaii's beetle-mimic cockroaches, which give birth to live young.

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Researchers looking to develop a long-acting, injectable malaria preventive using atovaquone have shown in a new study that resistance may not be the challenge scientists thought it was, particularly when using atovaquone as a malaria preventive. Malaria parasites in infected patients being treated with atovaquone tend to develop a resistance to the drug. Because of this, atovaquone by itself is not used as a malaria treatment nor has not been seen as a strong candidate for use as a preventive. 

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Turning unused waste from food production into clean energy: Researchers are using chicken feathers to make fuel cells more cost-effective and sustainable.

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Researchers have found a gene associated with longevity in golden retrievers, one of the most popular breeds of dogs.

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University and federal scientists used genetic sleuthing to study how salmon were affected by two major culvert replacements near the city of Bellingham. One project, a major upgrade under Interstate-5, had a big impact, while the other old culvert may have been less of a barrier to fish. Authors from the UW and NOAA are studying the use of environmental DNA, or eDNA, in future environmental impact reporting.

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New research unveils the cascading effects of periodical cicada emergence events on forest ecosystems ahead of an historic convergence of broods set to emerge spring of 2024.

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A plant geneticist and computational biologist teamed up to decipher the unpredictability of natural and engineered mutations in tomatoes. They discovered some combinations of mutations behave as expected while others are more erratic. Their work may help scientists find some order in the chaos of evolution and genome editing.

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The effects of extreme temperatures on avian reproduction can vary depending on the type of environment that birds call home. A new study found that extreme high temperatures significantly diminish bird reproductive success in agricultural landscapes.

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Whether a mouse is a good or bad parent can be traced back to imprinted genes in key neurons in the 'parenting hub' in the brain, according to a new study.

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Bats may have lived in caves and used soundwaves to navigate much earlier than first thought.

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Scientists have discovered the deepest known evidence of coral reef bleaching, more than 90 metres below the surface of the Indian Ocean. Identified during a research cruise, the damage to the deeper reefs in the Central Indian Ocean has been attributed to significant changes in the region's ocean temperature caused by the Indian Ocean Dipole. The researchers have also warned such incidences are only likely to increase as a result of present and future climate change.

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People who eat just two servings of red meat per week may have an increased risk of developing type 2 diabetes compared to people who eat fewer servings, and the risk increases with greater consumption, according to a new study. Researchers also found that replacing red meat with healthy plant-based protein sources, such as nuts and legumes, or modest amounts of dairy foods, was associated with reduced risk of type 2 diabetes.

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Proteins are important molecules that perform a variety of functions essential to life. To function properly, many proteins must fold into specific structures. However, the way proteins fold into specific structures is still largely unknown. Researchers have developed a novel physical theory that can accurately predict how proteins fold. Their model can predict things previous models cannot. Improved knowledge of protein folding could offer huge benefits to medical research, as well as to various industrial processes.

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Yeast cells are widely used to study G protein-coupled receptors (GPCRs), a large group of cell surface proteins in humans. However, several of these proteins lose their function when introduced into yeast cells. To tackle this issue, researchers developed an innovative strategy to restore GPCR function in yeast cells by inducing random mutations. Their findings can help understand GPCRs better and could pave the way to therapeutic breakthroughs for many diseases.

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Researchers have shown it's theoretically possible for black holes to exist in perfectly balanced pairs -- held in equilibrium by a cosmological force -- mimicking a single black hole.

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New findings point to 2 additional probiotics as potential treatments for high blood pressure.