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Categories: Biology: Biochemistry, Environmental: Water

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A new clinical trial suggests that a combination of the drug vorinostat and immunotherapy can coax HIV-infected cells out of latency and attack them. The findings highlight how close -- yet still far -- researchers have come to developing a cure for HIV-1.

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Researchers have shed new light on how viral evolution, population immunity, and the co-circulation of other flu viruses shape seasonal flu epidemics.

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Sandalwood oil has been used worldwide for centuries. Now, a study is the first to demonstrate in vivo the chemo-preventive properties of a by-product of the oil in a mouse model. Results show administering alpha-santalol reduced visible prostate tumors, protected the normal tissue, and delayed progression from a precancerous condition to a high-grade form of cancer. These findings are significant because mortality in prostate cancer patients is mainly attributable to advanced stages of the disease.

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More time stranded on land means greater risk of starvation for polar bears, a new study indicates. During three summer weeks, 20 polar bears closely observed by scientists tried different strategies to maintain energy reserves, including resting, scavenging and foraging. Yet nearly all of them lost weight rapidly: on average around 1 kilogram, or 2.2 pounds, per day. Some have speculated that polar bears might adapt to the longer ice-free seasons due to climate warming by acting like their grizzly bear relatives and either rest or eat terrestrial food. The polar bears in this study tried versions of both strategies -- with little success.

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New research revealed that when coral bleaching occurs, corals release unique organic compounds into the surrounding water that not only promote bacterial growth overall, but select for opportunistic bacteria that may further stress reefs.

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The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon aging. Researchers have discovered a new mechanism of action between the nutrient adaptation of intestinal stem cells and aging. The finding may make a difference when seeking ways to maintain the functional capacity of the aging gut.

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Fossils of a marine animal that lived 500 million years ago, combined with computer simulations, informed the design of a new soft robot.

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Charles Darwin -- arguably the most influential man of science in history, accumulated a vast personal library throughout his working life. Until now, 85 per cent of its contents were unknown or unpublished. This year, coinciding with Darwin's 215th birthday, The Complete Work of Charles Darwin Online, a scholarly project, has released an online 300-page catalogue detailing Darwin's complete personal library, with 7,400 titles across 13,000 volumes and items including books, pamphlets and journals.

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Researchers find deforestation accounts for about 10 percent of global human-made mercury emissions. While it cannot be the only solution, they suggest reforestation could increase global mercury uptake by about 5 percent.

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A new collaborative study analyzed fecal samples to shed light on how the fatal disease impacts the gut microbiome in deer, providing a promising tool for disease surveillance.

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Snail shells are often colorful and strikingly patterned. This is due to pigments that are produced in special cells of the snail and stored in the shell in varying concentrations. Fossil shells, on the other hand, are usually pale and inconspicuous because the pigments are very sensitive and have already decomposed. Residues of ancient color patterns are therefore very rare. This makes a new discovery all the more astonishing: researchers found pigments in twelve-million-year-old fossilized snail shells.

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Beaked whales are among the least studied mammals in the world. Now, a new study reveals surprising information about the Baird's beaked whale species.

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PFAS have earned the name 'forever chemicals' with good reason -- the human-made compounds, which can take thousands of years to degrade and are found in everything from grease-resistant food packaging to water-repellent clothing, have made their way into nearly half the U.S. tap water supply.

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Scientists have discovered that nighttime air pollution -- coming primarily form car exhaust and power plant emissions -- is responsible for a major drop in nighttime pollinator activity. Nitrate radicals (NO3) in the air degrade the scent chemicals released by a common wildflower, drastically reducing the scent-based cues that its chief pollinators rely on to locate the flower. The findings show how nighttime pollution creates a chain of chemical reactions that degrades scent cues, leaving flowers undetectable by smell. The researchers also determined that pollution likely has worldwide impacts on pollination.

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Researchers have discovered a previously unknown ability of a group of immune system cells, known as Atypical B cells (ABCs), to fight infectious diseases such as malaria. The scientists say ABCs could also be key to developing new treatments for chronic autoimmune conditions such as lupus.

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Researchers report the results of the first ever genome-wide association study (GWAS) of a biosafety level 4 (BSL-4) virus. The team found two key human genetic factors that could help explain why some people develop severe Lassa fever, and a set of LARGE1 variants linked to a reduced chance of getting Lassa fever. The work could lay the foundation for better treatments for Lassa fever and other similar diseases. The scientists are already working on a similar genetics study of Ebola susceptibility.

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Scientists have discovered a tiny worm species that infects and kills insects. These worms, called nematodes, could control crop pests in warm, humid places where other beneficial nematodes are currently unable to thrive.

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A newly discovered neural circuit mediates between navigational brain cells, acting as a sort of mental steering wheel.

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The same phosphorus that fertilizes the thriving agriculture of the Midwest is also responsible for a vast 'dead zone' in the Gulf of Mexico near the Mississippi Delta. Efforts to reduce the amount of phosphorus that enters the Mississippi River system are underway, but research suggests that remnants of the contaminant are left behind in riverbeds for years after introduction and pose an overlooked -- and lingering -- problem.

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Rocks once buried deep in ancient subduction zones -- where tectonic plates collide -- could help scientists make better predictions of how these zones behave during the years between major earthquakes, according to a research team.