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Categories: Biology: Biochemistry, Geoscience: Environmental Issues

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Researchers have found that a brain disorder associated with flu (influenza-associated encephalopathy, or IAE) can be caused by the influenza virus entering the brain from the blood via endothelial cells. In these cells, the researchers observed viral protein accumulation, suggesting that antivirals targeting viral transcription/translation may be useful treatments for some patients. Given the lack of effective treatments for IAE, this finding will likely improve patient care and reduce IAE-related deaths worldwide.

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Many natural substances possess interesting characteristics, and can form the basis of new active compounds in medicine. Terpenes, for example, are a group of substances, some of which are already used in therapies against cancer, malaria or epilepsy. They are found as fragrances in cosmetics or as flavorings in food, and form the basis of new medications: Terpenes are natural substances that occur in plants, insects and sea sponges. They are difficult to produce synthetically. However, chemists are now introducing a new method of synthesis.

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Researchers have deciphered the complex interplay of various enzymes around the innate immune receptor toll-like receptor 7 (TLR7), which plays an important role in defending our bodies against viruses.

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The alarming rates of biodiversity loss worldwide have made clear that the classical way of governing biodiversity recovery based on protected areas and programs for the protection of endangered species is not enough. To tackle this, almost 200 countries committed to the active 'mainstreaming' or integration of biodiversity targets into policies and plans across relevant sectors. However, research suggests that this has until now been largely ineffective due to non-binding commitments, vaguely formulated targets, 'add-on' biodiversity initiatives, and too few resources. 'Top down regulation is also needed,' say the authors.

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The length of telomeres in white blood cells, known as leukocytes, varies significantly among sub-Saharan African populations, researchers report. Moreover, leukocyte telomere length (LTL) is negatively associated with malaria endemicity and only partly explained by genetic factors.

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A wild orangutan was observed applying a plant with known medicinal properties to a wound, a first for a wild animal.

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Researchers discovered a concerning association between bacteremia and probiotic use, particularly with Clostridium butyricum (C. butyricum) MIYAIRI 588. Whole-genome sequencing revealed that all C. butyricum bacteremia strains were probiotic derivatives. Out of 6,576 cases of positive blood cultures, C. butyricum was detected in only five cases, all derived from probiotics. The study underscores rare but serious adverse events linked to probiotics, advocating cautious prescribing practices, especially for hospitalized patients.

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Researchers are on a mission to kill drug-resistant bacteria, and a new study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics.Researchers have shown that an antimicrobial peptide from cows has potential for treating incurable infections from the bacterium Klebsiella pneumoniae. The bacteria, commonly found in the intestines, is usually harmless. It becomes a health hazard when it enters other parts of the body and can cause pneumonia, urinary tract and wound infections. Those at highest risk include seniors and patients with other health problems such as diabetes, cancer, kidney failure and liver disease.

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A study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics. Scientists showed that an antimicrobial peptide from cows has potential for treating incurable infections from the bacterium Klebsiella pneumoniae. The bacteria, commonly found in the intestines, is usually harmless. It becomes a health hazard when it enters other parts of the body and can cause pneumonia, urinary tract and wound infections. Those at highest risk include seniors and patients with other health problems such as diabetes, cancer, kidney failure and liver disease.

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A parasite that not only feeds of its host, but also makes the host change its own metabolism and thus biology. Microbiologists have shown this for the very first time in a specific group of parasitic microbes, so-called DPANN archea. Their study shows that these archaea are very 'picky eaters', which might drive their hosts to change the menu.

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The Environmental Protection Agency (EPA) is underestimating methane emissions from landfills, urban areas and U.S. states, according to a new study. The researchers combined 2019 satellite observations with an atmospheric transport model to generate a high-resolution map of methane emissions, which was then compared to EPA estimates from the same year. The researchers found: Methane emissions from landfills are 51% higher compared to EPA estimates Methane emissions from 95 urban areas are 39% higher than EPA estimates Methane emissions from the 10 states with the highest methane emissions are 27% higher than EPA estimates.

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Viruses known as 'jumbo' phages are seen as a potential tool against deadly bacterial infections. But scientists must first decipher the extraordinary makeup of these mysterious viruses. Researchers have now uncovered a key piece of jumbo phage development that helps them counter bacteria.

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A study describes a new computer algorithm which can be applied to Earth System Models to drastically reduce the time needed to prepare these in order to make accurate predictions of future climate change. During tests on models used in IPCC simulations, the algorithm was on average 10 times faster at spinning up the model than currently-used approaches, reducing the time taken to achieve equilibrium from many months to under a week.

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Researchers have discovered the missing piece of the puzzle behind a rare opening in the sea ice around Antarctica, which was nearly twice the size of Wales and occurred during the winters of 2016 and 2017. A study reveals a key process that had eluded scientists as to how the opening, called a polynya, was able to form and persist for several weeks.

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Reaching net-zero carbon emissions goals requires finding transformative paths to manage carbon in difficult-to-electrify economic sectors.

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Scientists are harnessing cells to make new types of materials that can grow, repair themselves and even respond to their environment. These solid 'engineered living materials' are made by embedding cells in an inanimate matrix that's formed in a desired shape. Now, researchers have 3D printed a bioink containing plant cells that were then genetically modified, producing programmable materials. Applications could someday include biomanufacturing and sustainable construction.

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Researchers changed the composition of the gut microbiota in male mice through common antibiotics, inducing a condition called dysbiosis, and found that: - Mouse pups sired by a dysbiotic father show significantly lower birth weight, and have increased risk of growth disorders and postnatal mortality.

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Scientists have discovered that calcium plays a significant role in enhancing the resistance of potato plants to bacterial wilt.

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With recent studies having established the presence of nano and microplastic particles in the respiratory systems of both human and bird populations, new research has modeled what happens when people breathe in different kinds of plastic particles and where they end up.

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For the first time since 1914, a new species of the Japanese lily known as sukashiyuri has been identified. A research team analyzed the morphology and DNA of these lilies and has revised the conventional classification from four taxonomic groups to eight.