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Categories: Anthropology: Early Humans, Biology: Biochemistry

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An analysis of reviews of translational biomedical research reveals that just 5% of therapies tested in animals reach regulatory approval for human use. The umbrella review summarizes other systematic reviews and provides high level evidence that while the rate of translation to human studies is 50%, there is steep drop off before final approval.

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Some species of tardigrades are highly and unusually resilient to various extreme conditions fatal to most other forms of life. The genetic basis for these exceptional abilities remains elusive. Researchers have now successfully edited genes using the CRISPR technique in a highly resilient tardigrade species previously impossible to study with genome-editing tools. The successful delivery of CRISPR to an asexual tardigrade species directly produces gene-edited offspring. The design and editing of specific tardigrade genes allow researchers to investigate which are responsible for tardigrade resilience and how such resilience can work.

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The understanding of the global zinc cycle in our oceans has important implications in the context of warming oceans. A warmer climate increases erosion, leading to more dust in the atmosphere and consequently more dust being deposited into the oceans. More dust means more scavenging of zinc particles, leading to less zinc being available to sustain phytoplankton and other marine life, thereby diminishing the oceans' ability to absorb carbon.

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Researchers are unlocking the mystery of how bacteria harness viruses to wipe out the competition. The answers could help spur the development of alternatives to antibiotics.

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Paleontologists have identified a new genus of fossil goby, revealing evolutionary secrets of a lineage that stretches back millions of years.

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We may go to the woods seeking peace and quiet, but are we taking our noise with us? A recent study indicates that the answer is yes -- and that this noise can trigger a fear response, as if escaping from predators. This new science calls into question whether otherwise high-quality habitat truly provides refugia for wildlife when recreationists are present and underscores the challenges land managers face in balancing outdoor recreational opportunities with wildlife conservation.

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The increase in the frequency and intensity of marine heatwaves in recent decades is one of the effects of global climate change. A study shows that the extreme heatwave of 2022 caused an 'unprecedented' increase in mortality of the red gorgonian Paramuricea clavata, affecting 70% of the colonies located in the Montgr Natural Park, the Medes Islands and the Baix Ter. According to the researchers, these results are 'alarming and threaten the viability' of this species of great value for the biodiversity of benthic ecosystems, since it is considered to be an inhabitant-forming species.

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Geochemists used thallium isotopes to track the rise and fall of free oxygen on Earth between 2.5 and 2.2 billion years ago, the process that enabled life as we know it.

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Scientists have discovered a previously unknown link between two key pathways that regulate the immune system in mammals -- a finding that impacts our understanding of chronic inflammatory bowel diseases (IBD). This family of disorders severely impacts the health and quality of life of more than 2 million people in the United States.

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Researchers have found that germ cells, which develop into eggs and sperm, drive sex-dependent differences in lifespan in vertebrates. Female and male germ cells increase and reduce lifespan, respectively. These effects are controlled via estrogen and growth factor hormones in females and vitamin D in males. Vitamin D supplementation extends lifespan in both males and females. The results clarify the link between reproduction and aging and show that vitamin D may improve longevity in vertebrates.

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Studies working to map conservation historically have left humans out of the equation. This study proposes ways to build in the outsized footprint created by people in wild places.

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Goldenrod can perceive other plants nearby without ever touching them, by sensing far-red light ratios reflected off leaves. When goldenrod is eaten by herbivores, it adapts its response based on whether or not another plant is nearby. Is this kind of flexible, real-time, adaptive response a sign of intelligence in plants?

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A new study shows that analyzing nasal microbiota outperforms gut microbiota analysis to predict sepsis in the ICU.

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A mother's contribution to the makeup of a newborn baby's microbiota has been well documented. Now a new article shows the important contributions that fathers make to the composition of microorganisms colonizing a baby's gut as well. Furthermore, the study confirmed that maternal fecal microbiota transfer (FMT) in babies born by caesarean section can help to correct the microbiota disturbances often observed in babies who are not born vaginally.

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Mutations are changes in the molecular 'letters' that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including cancer. Now, a new study introduces an original technique, called HiDEF-seq, that can accurately detect the early molecular changes in DNA code that precede mutations.

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Researchers have reconstructed the evolutionary history and global spread of malaria over the past 5,500 years, identifying trade, warfare, and colonialism as major catalysts for its dispersal.

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Over 17 million insects migrate each year through a single mountain pass on the border between France and Spain, new research shows.

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Inspired by the material that makes up oyster and abalone shells, engineers have created a new cement composite that is 17 times more crack-resistant than standard cement and 19 times more able to stretch and deform without breaking. The findings could eventually help increase the crack resistance of a wide range of brittle ceramic materials from concrete to porcelain.

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Using tools of modern genetics, plant biochemists have produced a new high-yielding oilseed crop variety -- a yellow-seeded variety of Camelina sativa, a close relative of canola, that accumulates 21.4% more oil than ordinary camelina.

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Haiku poems have reflected humans' experiences in nature for hundreds of years, including observations of bugs and other wildlife. Recently, researchers analyzed which insects were mentioned the most in haiku -- with butterflies, fireflies and singing insects such as crickets topping the list.