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Categories: Anthropology: Early Humans, Biology: Biochemistry

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Replacing sugar with artificial and natural sweeteners in foods does not make people hungrier -- and also helps to reduce blood sugar levels, a significant new study has found. The double blind randomized controlled trial found that consuming food containing sweeteners produced a similar reduction in appetite sensations and appetite-related hormone responses as sugary foods -- and provides some benefits such as lowering blood sugar, which may be particularly important in people at risk of developing type 2 diabetes. The use of sweeteners in place of sugar in foods can be controversial due to conflicting reports about their potential to increase appetite. Previous studies have been carried out but did not provide robust evidence. However, the researchers say their study, which meets the gold standard level of proof in scientific investigation, provides very strong evidence that sweeteners and sweetness enhancers do not negatively impact appetite and are beneficial for reducing sugar intake.

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A research consortium provides evidence that social behavior and social status are reflected at the molecular level of gene activation (epigenome) in juvenile and adult free-ranging spotted hyenas. They analyzed non-invasively collected gut epithelium samples from both high-ranking and low-ranking female hyenas and showed that rank differences were associated with epigenetic signatures of social inequality, i.e., the pattern of activation or switching off of genes that regulate important physiological processes such as energy conversion and immune response in several genome regions.

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Researchers have identified how the tick-borne Crimean-Congo haemorrhagic fever virus enters our cells. The results are an important step in the development of drugs against the deadly disease.

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Through DNA sequencing of Tasmanian devils and their tumors, researchers have tracked the genomic interactions between the animals and the cancer.

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A recent study reveals an unexpected link between manganese -- a naturally occurring mineral -- and increased carbon emissions from high-latitude boreal forests. The study uncovers how manganese increases carbon emissions from boreal forest soil, over time, challenging conventional understanding of the role of manganese in the carbon cycle.

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A new bioluminescence imaging technique has created highly detailed, and visually striking, images of the movement of oxygen in the brains of mice. The method, which can be easily replicated by other labs, will enable researchers to more precisely study forms of hypoxia in the brain, such as the denial of oxygen to the brain that occurs during a stroke or heart attack. The new research tool is already providing insight into why a sedentary lifestyle may increase risk for diseases like Alzheimer's.

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Barley is one of the most important cereal crops on a global scale. Many barley cultivars produce a toxic alkaloid called gramine that affects the suitability of barley as fodder, but also helps to protect barley from pathogens. So far, the potential of manipulating gramine levels has not been harnessed for plant breeding, because the genetic basis of gramine production has been unresolved. Research groups now disclose the complete biosynthetic pathway of gramine and demonstrate how gramine biosynthesis can be introduced into model organisms or removed from barley.

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Biologists have uncovered a quality control timing mechanism tied to cell division. The 'stopwatch' function keeps track of mitosis and acts as a protective measure when the process takes too long, preventing the formation of cancerous cells.

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New DNA sequencing technologies have identified the historical remains of George Washington's grandnephews, Samuel Walter Washington and George Steptoe Washington Jr., and their mother, Lucy Payne Washington, from unmarked, fragmentary bones left at the Harewood family cemetery in Charles Town, West Virginia, in the mid-1800s.

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An analysis of how synaptic proteins change during early development reveals differences between mice and marmosets but also what's different in individuals with autism spectrum disorders. The findings offer first insights into the mechanism behind synaptic development and open up routes for research on possible treatments.

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Researchers have developed a new method to isolate HIV from samples more easily, potentially making it easier to detect infection with the virus. They focus on peptide nanofibrils (PNFs) on magnetic microparticles, a promising tool and hybrid material for targeted binding and separation of viral particles.

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How coral populations expand into new areas and sustain themselves over time is limited by the scope of modern observations. Going back thousands of years, a study provides geological insights into coral range expansions by reconstructing the composition of a Late Holocene-aged subfossil coral death assemblage in an unusual location in Southeast Florida and comparing it to modern reefs throughout the region. Findings offer a unique glimpse into what was once a vibrant coral reef assemblage and discover if history can repeat itself in the face of climate change.

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New research finds that not all cattle are the same when it comes to grazing, and knowing that could lead to better animal health and range conditions.

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Researchers have found that approved drugs that were originally shown to normalize blood vessels surrounding tumors (to improve drug delivery to cancer cells) can enhance the delivery of anti-microbial medications to kill tuberculosis bacteria residing in the lungs.

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Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants. Exploring sugarcane's genetic code could help researchers develop more resilient and productive crops, with implications for both sugar production and biofuels.

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Australian rock-wallabies are 'little Napoleons' when it comes to compensating for small size, packing much more punch into their bite than larger relatives. Researchers made the discovery while investigating how two dwarf species of rock-wallaby are able to feed themselves on the same kinds of foods as their much larger cousins.

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Researchers have recovered remarkably preserved microbiomes from two teeth dating back 4,000 years, found in an Irish limestone cave. Genetic analyses of these microbiomes reveal major changes in the oral microenvironment from the Bronze Age to today. The teeth both belonged to the same male individual and also provided a snapshot of his oral health.

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Researchers warn that today's hunting quotas of about 3,000 animals pose a risk to the long-term survival of the grey seal in the Baltic Sea. The conclusions of this new study are based on statistics from 20th century seal hunting and predictions of future climate change.

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This unusual, subterranean mammal with extreme longevity shows genetic adaptations to low oxygen environments which could offer opportunities for advancing other areas of physiological and medical research in humans, including the development of novel therapeutic approaches.

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Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them. To that end, a team of researchers has developed a way of using machine learning to rapidly predict multiple protein configurations to advance understanding of protein dynamics and functions.