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Categories: Biology: Biochemistry, Paleontology: Fossils

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Researchers have discovered that how a special protein complex called the Mediator moves along genes in DNA may have an impact on how cells divide. The discovery may be important for future research into the treatment of certain diseases.

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Researchers describe a natural product-like molecule, Tantalosin, that inhibits interaction between two proteins in complexes that reshape membranes inside the cell. The findings lead to a deeper understanding of how membrane remodeling works in human cells and future development of new drugs.

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Evidence from archaeological sites in the medieval English city of Winchester shows that English red squirrels once served as an important host for Mycobacterium leprae strains that caused leprosy in people, researchers report.

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Working with human breast and lung cells, scientists say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times, a hallmark of cancer cells.

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Natural malaria infections have been genetically analysed at a higher resolution than ever before, giving insights that could help understand and block transmission.

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Researchers have found that a brain disorder associated with flu (influenza-associated encephalopathy, or IAE) can be caused by the influenza virus entering the brain from the blood via endothelial cells. In these cells, the researchers observed viral protein accumulation, suggesting that antivirals targeting viral transcription/translation may be useful treatments for some patients. Given the lack of effective treatments for IAE, this finding will likely improve patient care and reduce IAE-related deaths worldwide.

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Many natural substances possess interesting characteristics, and can form the basis of new active compounds in medicine. Terpenes, for example, are a group of substances, some of which are already used in therapies against cancer, malaria or epilepsy. They are found as fragrances in cosmetics or as flavorings in food, and form the basis of new medications: Terpenes are natural substances that occur in plants, insects and sea sponges. They are difficult to produce synthetically. However, chemists are now introducing a new method of synthesis.

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Researchers have deciphered the complex interplay of various enzymes around the innate immune receptor toll-like receptor 7 (TLR7), which plays an important role in defending our bodies against viruses.

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The length of telomeres in white blood cells, known as leukocytes, varies significantly among sub-Saharan African populations, researchers report. Moreover, leukocyte telomere length (LTL) is negatively associated with malaria endemicity and only partly explained by genetic factors.

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A wild orangutan was observed applying a plant with known medicinal properties to a wound, a first for a wild animal.

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Researchers discovered a concerning association between bacteremia and probiotic use, particularly with Clostridium butyricum (C. butyricum) MIYAIRI 588. Whole-genome sequencing revealed that all C. butyricum bacteremia strains were probiotic derivatives. Out of 6,576 cases of positive blood cultures, C. butyricum was detected in only five cases, all derived from probiotics. The study underscores rare but serious adverse events linked to probiotics, advocating cautious prescribing practices, especially for hospitalized patients.

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Researchers are on a mission to kill drug-resistant bacteria, and a new study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics.Researchers have shown that an antimicrobial peptide from cows has potential for treating incurable infections from the bacterium Klebsiella pneumoniae. The bacteria, commonly found in the intestines, is usually harmless. It becomes a health hazard when it enters other parts of the body and can cause pneumonia, urinary tract and wound infections. Those at highest risk include seniors and patients with other health problems such as diabetes, cancer, kidney failure and liver disease.

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A study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics. Scientists showed that an antimicrobial peptide from cows has potential for treating incurable infections from the bacterium Klebsiella pneumoniae. The bacteria, commonly found in the intestines, is usually harmless. It becomes a health hazard when it enters other parts of the body and can cause pneumonia, urinary tract and wound infections. Those at highest risk include seniors and patients with other health problems such as diabetes, cancer, kidney failure and liver disease.

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A parasite that not only feeds of its host, but also makes the host change its own metabolism and thus biology. Microbiologists have shown this for the very first time in a specific group of parasitic microbes, so-called DPANN archea. Their study shows that these archaea are very 'picky eaters', which might drive their hosts to change the menu.

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Viruses known as 'jumbo' phages are seen as a potential tool against deadly bacterial infections. But scientists must first decipher the extraordinary makeup of these mysterious viruses. Researchers have now uncovered a key piece of jumbo phage development that helps them counter bacteria.

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A research team has found that ancient rocks and fossils from long-extinct marine reptiles in Angola clearly show a key part of Earth's past -- the splitting of South America and Africa and the subsequent formation of the South Atlantic Ocean.

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Scientists are harnessing cells to make new types of materials that can grow, repair themselves and even respond to their environment. These solid 'engineered living materials' are made by embedding cells in an inanimate matrix that's formed in a desired shape. Now, researchers have 3D printed a bioink containing plant cells that were then genetically modified, producing programmable materials. Applications could someday include biomanufacturing and sustainable construction.

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Researchers changed the composition of the gut microbiota in male mice through common antibiotics, inducing a condition called dysbiosis, and found that: - Mouse pups sired by a dysbiotic father show significantly lower birth weight, and have increased risk of growth disorders and postnatal mortality.

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Scientists have discovered that calcium plays a significant role in enhancing the resistance of potato plants to bacterial wilt.

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Researchers have provided new age estimates and revised provenance information for the Liujiang human fossils, shedding light on the presence of Homo sapiens in the region. Using advanced dating techniques including U-series dating on human fossils, and radiocarbon and optically stimulated luminescence dating on fossil-bearing sediments, the study revealed new ages ranging from approximately 33,000 to 23,000 years ago. Previously, studies had reported ages of up to 227,000 years of age for the skeleton.