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Categories: Biology: Biochemistry, Offbeat: Plants and Animals
Published Only one in 20 therapies tested in animals reach approval for human use
(via sciencedaily.com) Original source An analysis of reviews of translational biomedical research reveals that just 5% of therapies tested in animals reach regulatory approval for human use. The umbrella review summarizes other systematic reviews and provides high level evidence that while the rate of translation to human studies is 50%, there is steep drop off before final approval.
Published Modifying genomes of tardigrades to unravel their secrets
(via sciencedaily.com) Original source Some species of tardigrades are highly and unusually resilient to various extreme conditions fatal to most other forms of life. The genetic basis for these exceptional abilities remains elusive. Researchers have now successfully edited genes using the CRISPR technique in a highly resilient tardigrade species previously impossible to study with genome-editing tools. The successful delivery of CRISPR to an asexual tardigrade species directly produces gene-edited offspring. The design and editing of specific tardigrade genes allow researchers to investigate which are responsible for tardigrade resilience and how such resilience can work.
Published Scientists unravel drivers of the global zinc cycle in our oceans, with implications for a changing climate
(via sciencedaily.com) Original source The understanding of the global zinc cycle in our oceans has important implications in the context of warming oceans. A warmer climate increases erosion, leading to more dust in the atmosphere and consequently more dust being deposited into the oceans. More dust means more scavenging of zinc particles, leading to less zinc being available to sustain phytoplankton and other marine life, thereby diminishing the oceans' ability to absorb carbon.
Published The scary, yet promising world of phages, the pathogen's pathogen
(via sciencedaily.com) Original source Researchers are unlocking the mystery of how bacteria harness viruses to wipe out the competition. The answers could help spur the development of alternatives to antibiotics.
Published Paleontology: New fossil fish genus discovered
(via sciencedaily.com) Original source Paleontologists have identified a new genus of fossil goby, revealing evolutionary secrets of a lineage that stretches back millions of years.
Published Outdoor recreation noise affects wildlife behavior and habitat use, study finds
(via sciencedaily.com) Original source We may go to the woods seeking peace and quiet, but are we taking our noise with us? A recent study indicates that the answer is yes -- and that this noise can trigger a fear response, as if escaping from predators. This new science calls into question whether otherwise high-quality habitat truly provides refugia for wildlife when recreationists are present and underscores the challenges land managers face in balancing outdoor recreational opportunities with wildlife conservation.
Published Marine heatwaves devastate red gorgonians in the Medes Islands
(via sciencedaily.com) Original source The increase in the frequency and intensity of marine heatwaves in recent decades is one of the effects of global climate change. A study shows that the extreme heatwave of 2022 caused an 'unprecedented' increase in mortality of the red gorgonian Paramuricea clavata, affecting 70% of the colonies located in the Montgr Natural Park, the Medes Islands and the Baix Ter. According to the researchers, these results are 'alarming and threaten the viability' of this species of great value for the biodiversity of benthic ecosystems, since it is considered to be an inhabitant-forming species.
Published Eating small fish whole can prolong life expectancy, a Japanese study finds
(via sciencedaily.com) Original source A new study has found evidence linking the intake of whole-sized small fish with a reduced risk of all-cause and cancer mortality in Japanese women.
Published Soaring birds use their lungs to modify mechanics of flight
(via sciencedaily.com) Original source An air-filled sac within the birds' lungs is believed to increase the force the birds use to power flight muscles while soaring.
Published Ingestible microbiome sampling pill technology advances
(via sciencedaily.com) Original source Significant progress has been made in the development of a small device, about the size of a vitamin pill, that can be swallowed and passed through the gastrointestinal tract to sample and help identify the full inventory of microbiome bacteria in an individual.
Published What the geologic record reveals about how oceans were oxygenated 2.3 billion years ago
(via sciencedaily.com) Original source Geochemists used thallium isotopes to track the rise and fall of free oxygen on Earth between 2.5 and 2.2 billion years ago, the process that enabled life as we know it.
Published Putting the brakes on chronic inflammation
(via sciencedaily.com) Original source Scientists have discovered a previously unknown link between two key pathways that regulate the immune system in mammals -- a finding that impacts our understanding of chronic inflammatory bowel diseases (IBD). This family of disorders severely impacts the health and quality of life of more than 2 million people in the United States.
Published The gender gap in life expectancy: Are eggs and sperm partly responsible?
(via sciencedaily.com) Original source Researchers have found that germ cells, which develop into eggs and sperm, drive sex-dependent differences in lifespan in vertebrates. Female and male germ cells increase and reduce lifespan, respectively. These effects are controlled via estrogen and growth factor hormones in females and vitamin D in males. Vitamin D supplementation extends lifespan in both males and females. The results clarify the link between reproduction and aging and show that vitamin D may improve longevity in vertebrates.
Published Humans are the elephant in the room where conservation is debated
(via sciencedaily.com) Original source Studies working to map conservation historically have left humans out of the equation. This study proposes ways to build in the outsized footprint created by people in wild places.
Published No bones about it: 100-million-year-old bones reveal new species of pterosaur
(via sciencedaily.com) Original source New research has identified 100-million-year-old fossilized bones discovered in western Queensland as belonging to a newly identified species of pterosaur, which was a formidable flying reptile that lived among the dinosaurs.
Published Are plants intelligent? It depends on the definition
(via sciencedaily.com) Original source Goldenrod can perceive other plants nearby without ever touching them, by sensing far-red light ratios reflected off leaves. When goldenrod is eaten by herbivores, it adapts its response based on whether or not another plant is nearby. Is this kind of flexible, real-time, adaptive response a sign of intelligence in plants?
Published Nasal microbiota is potential diagnostic biomarker for sepsis
(via sciencedaily.com) Original source A new study shows that analyzing nasal microbiota outperforms gut microbiota analysis to predict sepsis in the ICU.
Published Study shows role of fathers in seeding the microbiota of newborns and confirms benefits of maternal fecal microbiota transplants
(via sciencedaily.com) Original source A mother's contribution to the makeup of a newborn baby's microbiota has been well documented. Now a new article shows the important contributions that fathers make to the composition of microorganisms colonizing a baby's gut as well. Furthermore, the study confirmed that maternal fecal microbiota transfer (FMT) in babies born by caesarean section can help to correct the microbiota disturbances often observed in babies who are not born vaginally.
Published New technique reveals earliest signs of genetic mutations
(via sciencedaily.com) Original source Mutations are changes in the molecular 'letters' that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including cancer. Now, a new study introduces an original technique, called HiDEF-seq, that can accurately detect the early molecular changes in DNA code that precede mutations.
Published Origin and spread of malaria
(via sciencedaily.com) Original source Researchers have reconstructed the evolutionary history and global spread of malaria over the past 5,500 years, identifying trade, warfare, and colonialism as major catalysts for its dispersal.