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Categories: Biology: Biochemistry, Chemistry: Biochemistry

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Researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol. The team discovered a link between 4PY, a breakdown product from excess niacin, and heart disease. Higher circulating levels of 4PY were strongly associated with development of heart attack, stroke and other adverse cardiac events in large-scale clinical studies. The researchers also showed in preclinical studies that 4PY directly triggers vascular inflammation which damages blood vessels and can lead to atherosclerosis over time.

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Instead of carrying the babies until they hatched, as in most species of sea spiders, one parent (likely the father) spent two days attaching the eggs to the rocky bottom where they developed for several months before hatching as tiny larvae.

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A research team that had previously succeeded in synthesizing fumaric acid using bicarbonate and pyruvic acid, and carbon dioxide collected directly from the gas phase as one of the raw materials, has now created a new photosensitizer and developed a new artificial photosynthesis technology, effectively doubling the yield of fumaric acid production compared to the previous method. The results of this research are expected to reduce carbon dioxide emissions and provide an innovative way to produce biodegradable plastics while reusing waste resources.

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Palaeontological analysis shows that a renowned fossil thought to show soft tissue preservation is in fact just paint. The fossil discovered in 1931 was thought to be an important specimen for understanding early reptile evolution. While not all of the celebrated fossil is a forgery, scientists urge caution in how the fossil is utilized in future.

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Researchers studied the composition and function of bacteria in the seabed off Svalbard, during alternating periods of polar night and midnight sun. To do this, they specially developed a sampling device, the Ellrott grab. In contrast with bacterial communities in the overlying water, the sediment bacteria hardly change with the seasons. This is probably due to the fact that in the seabed some hard-to-digest foods are available all year round.

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Researchers have identified a protein that evolved concurrently with the emergence of cellular compartments crucial for the multiplication of the toxoplasmosis pathogen.

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Researchers propose a framework for integrating online digital data into biodiversity monitoring.

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Researchers have found genes in the reproductive organs of bulls that influence fertility. The findings can be transferred to humans, as these genes are also present in men.

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In creating five new isotopes, scientists have brought the stars closer to Earth. The isotopes are known as thulium-182, thulium-183, ytterbium-186, ytterbium-187 and lutetium-190.

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A new antibiotic overcomes antimicrobial resistance mechanisms that have rendered many modern drugs ineffective and are driving a global public health crisis.

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A new model bridges the rules of life at the individual scale and the ecosystem level, which could open new avenues of exploration in ecology, global change biology, and ultimately ecosystem management.

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Scientists may have figured out why some people have trouble digesting sorbitol, a sugar alcohol used in sugar-free gum, mints, candy and other products.

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Scientists have developed a new method to measure and remove sulfate from water, potentially leading to cleaner waterways and more effective nuclear waste treatments.

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Researchers have completed one of the most extensive river resilience studies, examining how river ecosystems recover following floods. They developed a novel modeling approach that used data from oxygen sensors placed in rivers to estimate daily growth in aquatic plants and algae. The researchers then modeled the algal and plant biomass in 143 rivers across the contiguous U.S. to quantify what magnitude of flooding disturbs the biomass and how long the rivers take to recover from floods. Increased understanding of rivers' resiliency is important to maintaining healthy rivers, as human actions can affect flood regimes and change the conditions in rivers for other aquatic life that may rely on algae and plants as a food source.

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Researchers found that the oral bacterium Streptococcus gordonii activates another bacterial species, Fusobacterium nucleatum, to produce large quantities of methyl mercaptan, a compound responsible for bad breath. Disrupting this interaction could therefore help treat halitosis, and possibly also help prevent the development of more serious tooth and gum disease.

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Scientists take innovation in coral e-DNA monitoring to the next level.

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When the female gametes in plants become fertilized, a signal from the sperm activates cell division, leading to the formation of new plant seeds. This activation can also be deliberately triggered without fertilization, as researchers have shown. Their findings open up new avenues for the asexual propagation of crop plants.

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The fields of chemistry and materials science are seeing a surge of interest in 'self-driving labs,' which make use of artificial intelligence and automated systems to expedite research and discovery. Researchers are now proposing a suite of definitions and performance metrics that will allow researchers, non-experts, and future users to better understand both what these new technologies are doing and how each technology is performing in comparison to other self-driving labs.

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A new study has explored the link between diet and cognitive function, and the results reveal that a protein-rich breakfast can increase satiety and improve concentration. This is important knowledge in a society with increasing obesity rates and lifestyle-related diseases.

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You'd think the complex flavor in a quality cup of tea would depend mainly on the tea varieties used to make it. But a new study shows that the making of a delicious cup of tea depends on another key ingredient: the collection of microbes found on tea roots. By altering that assemblage, the authors showed that they could make good-quality tea even better.