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Categories: Biology: Biochemistry, Chemistry: Biochemistry

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Researchers report the results of the first ever genome-wide association study (GWAS) of a biosafety level 4 (BSL-4) virus. The team found two key human genetic factors that could help explain why some people develop severe Lassa fever, and a set of LARGE1 variants linked to a reduced chance of getting Lassa fever. The work could lay the foundation for better treatments for Lassa fever and other similar diseases. The scientists are already working on a similar genetics study of Ebola susceptibility.

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Researchers have identified a new way to harness the antioxidant and antibacterial properties of a botanical compound to make nanofiber-coated cotton bandages that fight infection and help wounds heal more quickly.

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Engineers have pioneered a new way to visualize the smallest protein clusters, skirting the physical limitations of light-powered microscopes and opening new avenues for detecting the proteins implicated in diseases like Alzheimer's and testing new treatments.

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A novel PET imaging technique can noninvasively detect active inflammation in the body before clinical symptoms arise, according to new research. Using a PET tracer that binds to proteins present on activated immune cells, the technique produces images of ongoing inflammation throughout the body, such as rheumatoid arthritis. This makes it easier for physicians to correctly diagnose and treat patients.

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A new fusion of materials, each with special electrical properties, has all the components required for a unique type of superconductivity that could provide the basis for more robust quantum computing.

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An advanced human heart organoid system can be used to model embryonic heart development under pregestational diabetes-like conditions, researchers report. The organoids recapitulate hallmarks of pregestational diabetes-induced congenital heart disease found in mice and humans. The findings also showed that endoplasmic reticulum (ER) stress and lipid imbalance are critical factors contributing to these disorders, which could be ameliorated with exposure to omega-3s.

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Scientists have discovered a tiny worm species that infects and kills insects. These worms, called nematodes, could control crop pests in warm, humid places where other beneficial nematodes are currently unable to thrive.

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A newly discovered neural circuit mediates between navigational brain cells, acting as a sort of mental steering wheel.

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Researchers have shed new light on the ancient relationship between moss and fungi. They discovered that intricate moss-fungi interactions often depended on a third variable -- the presence of endobacteria within the fungi themselves.

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Tiny external structures in the wax coating of blueberries give them their blue color, researchers reveal.

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Researchers have made a groundbreaking discovery: a new cell that remembers allergies.

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Researchers report that replacing 50% of animal products with alternative proteins by 2050 could free up enough agricultural land to generate renewable energy equivalent in volume to today's coal-generated power while simultaneously removing substantial CO2 from the atmosphere.

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Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers combined multiple sequencing and experimental techniques to map the relationship between known CAD variants and the biological pathways they impact.

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Researchers say hydroquinine could be an effective naturally occurring disinfecting solution for contact lenses and help combat keratitis infections.

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Forests, which cover a third of Earth's land surface, are pivotal in carbon storage and the water cycle, though the full scope of their impact remains to be fully understood. In a new study, researchers provide new insights into the complex role forests play in the climate system and water cycle.

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Data from a representative sample of the Austrian population suggests that the relationship between nature contact and well-being is consistently stronger for people on lower than higher incomes. However, this pattern was only found when people actively visited nature and not when they merely lived near greenspaces. Findings suggest the availability, accessibility and use of green and blue spaces can play an important role in reducing income-related health inequalities.

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The ability to detect diseases at an early stage or even predict their onset would be of tremendous benefit to doctors and patients alike. A research team now develops intelligent, miniaturized biosensor devices and systems using nanomaterials to determine biomolecules and cells as well as biochemical reactions or processes as disease markers. The team's current publication describes the development of a portable, palm-sized test system that can simultaneously carry out up to thirty-two analyses of one sample.

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Carboxylic acid dianions (fumarate, maleate and succinate) play a role in coordination chemistry and to some extent also in the biochemistry of body cells. A team has now analyzed their electronic structures using RIXS in combination with DFT simulations. The results provide information not only on electronic structures but also on the relative stability of these molecules which can influence an industry's choice of carboxylate dianions, optimizing both the stability and geometry of coordination polymers.

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New study suggests that temperature can influence the microbial competition in rivers.

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Bacteria in the mouth may play a role in survival from idiopathic pulmonary fibrosis (IPF), finds a new study.