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Categories: Biology: Biochemistry, Chemistry: Biochemistry

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Researchers have discovered new insights into the human heart's structure, revealing its evolutionary history. This study enhances understanding of heart development and its implications for treating heart disease.

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CRISPR/Cas9 gene editing has made possible a multitude of biomedical experiments including studies that systematically turn off genes in cancer cells to look for ones that the cancer cells heavily depend on to survive and grow. These genes, or 'cancer dependencies,' are often promising drug targets. But new research shows that many of these CRISPR screening experiments rely on components, called CRISPR/Cas9 guides, that do not perform equally well in cells from people of all ancestries, which can cause CRISPR screens to miss cancer dependencies.

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Filamentous cyanobacteria buckle at a certain length when they encounter an obstacle. The results provide an important basis for the use of cyanobacteria in modern biotechnology.

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Researchers have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system's ability to fight cancer. The team showed promising results for the new therapy in cancer cells in the lab and in mouse lung tumor models, with potential applications for improving care and outcomes for patients with tumors that have failed to respond to traditional immunotherapy.

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A new study has shown for the first time that when sandhoppers want to enter a period of deep sleep each winter they have the means through which to increase the magnesium levels in their bodies -- in some instances more than doubling them. Essentially acting as a natural narcotic, the magnesium puts the sandhopper into a torpid state and this enforced rest means that the creatures can stay hidden in burrows up to 30cm beneath the beach surface, to some extent buffered from wintry conditions.

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A low vitamin B6 level has negative effects on brain performance. A research team has now found a way to delay the degradation of the vitamin.

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Layers of carbon atoms in a honeycomb array are a true supermaterial: their unusually high conductivity and favorable mechanical properties could further the development of bendable electronics, new batteries, and innovative composite materials for aeronautics and space flight. However, the development of elastic and tough films remains a challenge. A research team has now introduced a method to overcome this hurdle: they linked graphene nanolayers via 'extendable' bridging structures.

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In mammals, only 3% of the genome consists of coding genes which, when transcribed into proteins, ensure the biological functions of the organism and the in-utero development of future individuals. But genes do not function alone. They are controlled by other sequences in the genome, called enhancers, which, like switches, activate or deactivate them as required. A team has now identified and located 2700 enhancers -- among millions of non-coding genetic sequences -- that precisely regulate the genes responsible for bone growth. This discovery sheds light on one of the major factors influencing the size of individuals in adulthood, and explains why their failure could be the cause of certain bone malformations.

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Scientists have unraveled the ancestral history of one of the most iconic birds of prey in the current Iberian fauna: the Bonelli's eagle (Aquila fasciata). The study combines evidence from several disciplines, including palaeontology, genetics and ecology, to answer questions about when and why the Bonelli's eagle, a species primarily found in tropical and subtropical areas, colonized the Mediterranean Basin.

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Researchers have succeeded in developing a DNA-based molecular controller. Crucially, this controller enables the autonomous assembly and disassembly of molecular robots, as opposed to manually directing it.

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An international research team has uncovered a new insight into human evolution by comparing humans' hearts with those of other great apes.

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Scientists are rethinking the evolution of vocal learning in birds. New Zealand's smallest bird, the rifleman or titipounamu, may have a rudimentary version of the talent possessed by parrots, hummingbirds and songbirds.

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A team of researchers has shown for the first time that fasting can reprogram the metabolism of natural killer cells, helping them to survive in the harsh environment in and around tumors, while also improving their cancer-fighting ability.

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The amount of infectious H5N1 influenza viruses in raw milk rapidly declined with heat treatment in laboratory research. However, small, detectable amounts of infectious virus remained in raw milk samples with high virus levels when treated at 72 degrees Celsius (161.6 degrees Fahrenheit) for 15 seconds -- one of the standard pasteurization methods used by the dairy industry. The authors of the study stress, however, that their findings reflect experimental conditions in a laboratory setting and are not identical to large-scale industrial pasteurization processes for raw milk.

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Scientists address decades-long problem in the field of single-molecule fluorescence resonance energy transfer, paving the way for more accurate experiments.

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Climate change is making it more difficult to raise cattle -- growth and reproduction are affected by heat -- so it's critical to breed cattle better adapted to a hotter and longer summer. A new study shows it's possible to identify the genes within breeds of cattle that would lead to the sweatiest, heat-tolerant offspring.

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Researchers have made a significant breakthrough in how to enable and exploit ultra-fast spin behavior in ferromagnets. The research paves the way for ultra-high frequency applications.

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Researchers have developed new chemistry to achieve commercially relevant stability and performance for perovskite solar cells.

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New research may help close the nutrition gap between infant formula and human breast milk. The study shows how plants can be programmed to produce a diverse array of beneficial sugars found in human breast milk. The findings could lead to healthier and more affordable formula for babies, or more nutritious non-dairy plant milk for adults.

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With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.