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Categories: Biology: Biotechnology, Chemistry: Organic Chemistry
Published Researchers decipher new molecular mechanisms related to biological tissue regeneration
(via sciencedaily.com) Original source A study opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work. The study focuses on tumor necrosis factor- (TNF- ) and its receptors TNFR, molecules of key interest in biomedicine due to their involvement in multiple diseases such as obesity related to type 2 diabetes mellitus, inflammatory bowel disease and several types of cancer.
Published New additive process can make better -- and greener -- high-value chemicals
(via sciencedaily.com) Original source Researchers have achieved a significant breakthrough that could lead to better -- and greener -- agricultural chemicals and everyday products. Using a process that combines natural enzymes and light, the team developed an eco-friendly way to precisely mix fluorine, an important additive, into chemicals called olefins -- hydrocarbons used in a vast array of products, from detergents to fuels to medicines. This groundbreaking method offers an efficient new strategy for creating high-value chemicals with potential applications in agrochemicals, pharmaceuticals, renewable fuels, and more.
Published Pioneering measurement of the acidity of ionic liquids using Raman spectroscopy
(via sciencedaily.com) Original source A study has made it possible to estimate experimentally the energy required to transfer protons from water to ionic liquids.
Published Lampreys possess a 'jaw-dropping' evolutionary origin
(via sciencedaily.com) Original source Lampreys are one of only two living jawless vertebrates Jaws are formed by a key stem cell population called the neural crest New research reveals the gene regulatory changes that may explain morphological differences between jawed and jawless vertebrates.
Published 'Miracle' filter turns store-bought LEDs into spintronic devices
(via sciencedaily.com) Original source Scientists transformed existing optoelectronic devices into ones that can control electron spin at room temperature, without a ferromagnet or magnetic field. Researchers replaced the electrodes of store-bought LEDs with a patented spin filter made from hybrid organic-inorganic halide perovskite.
Published How molecular interactions make it possible to overcome the energy barrier
(via sciencedaily.com) Original source Non-reciprocal interactions allow the design of more efficient molecular systems. Scientists now propose a mechanism on how energy barriers in complex systems can be overcome. These findings can help to engineer molecular machines and to understand the self-organization of active matter.
Published Researchers explore the interplay between high-affinity DNA and carbon nanotubes
(via sciencedaily.com) Original source Single-walled carbon nanotubes (SWCNTs) hold promise for biomedicine and nanoelectronics, yet the functionalization with single-stranded DNA (ssDNA) remains a challenge. Researchers using high-affinity ssDNA sequences identified through high-throughput selection. They demonstrated the effectivity and stability of these constructs using molecular dynamics simulations. Machine-learning models were used to accurately predict patterns that govern ssDNA-SWCNT binding affinity. These findings provide valuable insights into the interactions between ssDNA and SWCNTs.
Published Scientists identify key protein behind spread of shingles virus
(via sciencedaily.com) Original source Scientists have discovered a new evasion strategy used by the varicella zoster virus, which causes chickenpox and shingles, that may allow it to affect tissues far from the original site of infection.
Published Better way to produce green hydrogen
(via sciencedaily.com) Original source Researchers have developed a material that shows a remarkable ability to convert sunlight and water into clean energy.
Published Tackling industrial emissions begins at the chemical reaction
(via sciencedaily.com) Original source Researchers are proposing a new way to curb industrial emissions, by tapping into the 'atomic intelligence' of liquid metals to deliver greener and more sustainable chemical reactions.
Published Researchers are closing in on a mouse model for late-onset Alzheimer's
(via sciencedaily.com) Original source Researchers are working to create the first strain of mice that's genetically susceptible to late-onset Alzheimer's, with potentially transformative implications for dementia research.
Published A single-molecule-based organic porous material with great potential for efficient ammonia storage
(via sciencedaily.com) Original source Novel porous crystalline solid shows promise as an efficient and durable material for ammonia (NH3) capture and storage, report scientists. Made through a simple reprecipitation process, the proposed organic compound can reversibly adsorb and release NH3 via simple pressurization and decompression at room temperature. Its stability and cost-effectiveness make this material a promising energy carrier for future hydrogen economies.
Published Research sheds light on the role of PTPRK in tissue repair and cancer
(via sciencedaily.com) Original source New research has advanced our knowledge of multiple roles for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell-cell adhesion, growth factor signalling and tumor suppression. Through a characterization of the function of PTPRK in human cell lines and mice, the team distinguished catalytic and non-catalytic functions of PTPRK. The findings extend what is known about the signalling mechanisms involving PTPRK as a phosphatase and its role in colorectal health but also shed new light on the extent of its function via non-catalytic signalling mechanisms.
Published Under pressure: How cells respond to physical stress
(via sciencedaily.com) Original source Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists have used cryo-electron microscopy to observe how lipids and proteins at the plasma membrane interact and react to mechanical stress. This work shows that, depending on conditions, small membrane regions can stabilize various lipids to trigger specific cellular responses. These discoveries confirm the existence of well-organized lipid domains and begin to reveal the role they play in cell survival.
Published Nanoscopic imaging aids in understanding protein, tissue preservation in ancient bones
(via sciencedaily.com) Original source A pilot study shows that nanoscopic 3-D imaging of ancient bone not only provides further insight into the changes soft tissues undergo during fossilization, it also has potential as a fast, practical way to determine which specimens are likely candidates for ancient DNA and protein sequence preservation.
Published Dual action antibiotic could make bacterial resistance nearly impossible
(via sciencedaily.com) Original source New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance.
Published New rapid method for determining virus infectivity
(via sciencedaily.com) Original source A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionize the response to future pandemics, researchers report.
Published B cell biohack: Immune cells to churn out custom antibodies
(via sciencedaily.com) Original source Scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody factories that can pump out specially designed antibodies to destroy cancer cells or HIV, two of medicine's most formidable foes.
Published New genetic test will eliminate a form of inherited blindness in dogs
(via sciencedaily.com) Original source Scientists have identified the genetic mutation that causes progressive retinal atrophy in English Shepherd Dogs, which results in incurable blindness, and developed a genetic test to help eliminate the disease from future generations of the breed.
Published Exposing dengue's invasion strategies
(via sciencedaily.com) Original source Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for this disease. Now, research uncovered surprising strategies for how dengue and hundreds of other viruses replicate in their hosts, with the potential to aid in developing novel antiviral treatments and vaccines.