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Categories: Biology: Biotechnology, Chemistry: Organic Chemistry
Published Researchers discover new cell that remembers allergies
(via sciencedaily.com) Original source Researchers have made a groundbreaking discovery: a new cell that remembers allergies.
Published New research uncovers biological drivers of heart disease risk
(via sciencedaily.com) Original source Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers combined multiple sequencing and experimental techniques to map the relationship between known CAD variants and the biological pathways they impact.
Published BESSY II: Molecular orbitals determine stability
(via sciencedaily.com) Original source Carboxylic acid dianions (fumarate, maleate and succinate) play a role in coordination chemistry and to some extent also in the biochemistry of body cells. A team has now analyzed their electronic structures using RIXS in combination with DFT simulations. The results provide information not only on electronic structures but also on the relative stability of these molecules which can influence an industry's choice of carboxylate dianions, optimizing both the stability and geometry of coordination polymers.
Published New approach to tackling bacterial infections identified
(via sciencedaily.com) Original source Researchers have identified a new approach to controlling bacterial infections. The team found a way to turn on a vital bacterial defense mechanism to fight and manage bacterial infections. The defense system, called cyclic oligonucleotide-based antiphage signaling system (CBASS), is a natural mechanism used by certain bacteria to protect themselves from viral attacks. Bacteria self-destruct as a means to prevent the spread of virus to other bacterial cells in the population.
Published Researchers discover key to molecular mystery of how plants respond to changing conditions
(via sciencedaily.com) Original source A team of researchers recently published a pioneering study that answers a central question in biology: how do organisms rally a wide range of cellular processes when they encounter a change -- either internally or in the external environment -- to thrive in good times or survive the bad times? The research, focused on plants, identifies the interactions between four compounds: pectin, receptor proteins FERONIA and LLG1 and the signal RALF peptide.
Published Chemists decipher reaction process that could improve lithium-sulfur batteries
(via sciencedaily.com) Original source Lithium-sulfur batteries have exceptional theoretical capacity and performance in combination with an element in abundant supply. But the intricate reaction mechanism, particularly during discharge, has been challenging to solve. Researchers have identified the key pathways to a complex sulfur reduction reaction that leads to energy loss and reduced battery life span. The study's findings establish the whole reaction network for the first time and offer insight into electrocatalyst design for improved batteries.
Published Improving fuel cell durability with fatigue-resistant membranes
(via sciencedaily.com) Original source In hydrogen fuel cells, electrolyte membranes frequently undergo deformation and develop cracks during operation. A research team has recently introduced a fatigue-resistant polymer electrolyte membrane for hydrogen fuel cells, employing an interpenetrating network of Nafion (a plastic electrolyte) and perfluoropolyether (a rubbery polymer). This innovation will not only improve fuel cell vehicles but also promises advancements in diverse technologies beyond transportation, spanning applications from drones to desalination filters and backup power sources.
Published Scientists develop new biocontainment method for industrial organisms
(via sciencedaily.com) Original source Researchers have developed a new biocontainment method for limiting the escape of genetically engineered organisms used in industrial processes.
Published Extra fingers and hearts: Pinpointing changes to our genetic instructions that disrupt development
(via sciencedaily.com) Original source Scientists can now predict which single-letter changes to the DNA within our genomes will alter genetic instructions and disrupt development, leading to changes such as the growth of extra digits and hearts. Such knowledge opens the door to predictions of which enhancer variants underlie disease in order to harness the full potential of our genomes for better human health.
Published Down to the core of poxviruses
(via sciencedaily.com) Original source A recent re-emergence and outbreak of Mpox brought poxviruses back as a public health threat, underlining an important knowledge gap at their core. Now, a team of researchers lifted the mysteries of poxviral core architecture by combining various cryo-electron microscopy techniques with molecular modeling.
Published Computer-engineered DNA to study cell identities
(via sciencedaily.com) Original source A new computer program allows scientists to design synthetic DNA segments that indicate, in real time, the state of cells. It will be used to screen for anti-cancer or viral infections drugs, or to improve gene and cell-based immunotherapies.
Published Microbial division of labor produces higher biofuel yields
(via sciencedaily.com) Original source Scientists have found a way to boost ethanol production via yeast fermentation, a standard method for converting plant sugars into biofuels. Their approach relies on careful timing and a tight division of labor among synthetic yeast strains to yield more ethanol per unit of plant sugars than previous approaches have achieved.
Published Ultra-sensitive lead detector could significantly improve water quality monitoring
(via sciencedaily.com) Original source Engineers have developed an ultra-sensitive sensor made with graphene that can detect extraordinarily low concentrations of lead ions in water. The device achieves a record limit of detection of lead down to the femtomolar range, which is one million times more sensitive than previous technologies.
Published New technology unscrambles the chatter of microbes
(via sciencedaily.com) Original source Researchers have developed a new search tool to that can match microbes to the metabolites they produce with no prior knowledge, an innovation that could transform our understanding of both human health and the environment.
Published Mechanism discovered that protects tissue after faulty gene expression
(via sciencedaily.com) Original source A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic approaches to treat diseases caused by faulty splicing.
Published Edge-to-edge assembly technique for 2D nanosheets
(via sciencedaily.com) Original source A research team develops edge-to-edge assembly technique for 2D nanosheets.
Published Disrupted cellular function behind type 2 diabetes in obesity
(via sciencedaily.com) Original source Disrupted function of 'cleaning cells' in the body may help to explain why some people with obesity develop type 2 diabetes, while others do not. A study describes this newly discovered mechanism.
Published A clutch stretch goes a long way
(via sciencedaily.com) Original source New results reveal a new mode of force transmission in which dynamic molecular stretching bridges the extracellular matrix and flowing F-actin moving at different speeds. This discovery underscores the necessity of molecular elasticity and random coupling for sufficiently transmitting force. The findings also call for revising the role of molecular unfolding.
Published Resistant bacteria can remain in the body for years
(via sciencedaily.com) Original source Fighting disease-causing bacteria becomes more difficult when antibiotics stop working. People with pre-existing conditions in particular can carry resistant germs and suffer from repeated infections for years, according to a new study.
Published Gut bacteria can process dietary fiber into an anti-allergy weapon
(via sciencedaily.com) Original source Short-chain fatty acids (SCFAs), which are produced by gut bacteria from dietary fiber, regulate our immune system, but the mechanism of their action remains unknown. In a recent study, researchers investigated how SCFAs interact with mast cells, a type of white blood cell that plays a central role in allergic reactions. Their findings and insights could lead to innovative and effective anti-allergy medications, supplements, and diets, paving the way for healthier lives.