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Categories: Biology: Biotechnology, Chemistry: Thermodynamics

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New research has advanced our knowledge of multiple roles for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell-cell adhesion, growth factor signalling and tumor suppression. Through a characterization of the function of PTPRK in human cell lines and mice, the team distinguished catalytic and non-catalytic functions of PTPRK. The findings extend what is known about the signalling mechanisms involving PTPRK as a phosphatase and its role in colorectal health but also shed new light on the extent of its function via non-catalytic signalling mechanisms.

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Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists have used cryo-electron microscopy to observe how lipids and proteins at the plasma membrane interact and react to mechanical stress. This work shows that, depending on conditions, small membrane regions can stabilize various lipids to trigger specific cellular responses. These discoveries confirm the existence of well-organized lipid domains and begin to reveal the role they play in cell survival.

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A prototype device harvests drinking water from the atmosphere, even in arid places.

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Chemists have developed a rapid electrothermal mineralization (REM) process, which in seconds can remediate the accumulation of synthetic chemicals that can contaminate soil and the environment.

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Faced with the world's impending freshwater scarcity, researchers turned to solar steam generators, which are emerging as a promising device for seawater desalination. The team sought design inspiration from trees and harnessed the potential of 3D printing. They present technology for producing efficient SSGs for desalination and introduces a novel method for printing functional nanocomposites for multi-jet fusion. Their SSGs were inspired by plant transpiration and are composed of miniature tree-shaped microstructures, forming an efficient, heat-distributing forest.

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New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance.

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A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionize the response to future pandemics, researchers report.

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Scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody factories that can pump out specially designed antibodies to destroy cancer cells or HIV, two of medicine's most formidable foes.

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Scientists have identified the genetic mutation that causes progressive retinal atrophy in English Shepherd Dogs, which results in incurable blindness, and developed a genetic test to help eliminate the disease from future generations of the breed.

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Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for this disease. Now, research uncovered surprising strategies for how dengue and hundreds of other viruses replicate in their hosts, with the potential to aid in developing novel antiviral treatments and vaccines.

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Researchers have found a new way to identify genetic targets useful for control of mosquito populations, potentially offering an alternative to insecticides. Their study focused on the genetic basis of species incompatibility. They crossed Ae. aegypti, a major global arboviral disease vector, and its sibling species, Ae. mascarensis, from the Indian Ocean. When offspring is crossed back with one parent, about 10 percent of the progeny becomes intersex and is unable to reproduce.

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A little leg may reveal something big about how closely related insect species can drastically differ in body shape, according to a new study. The team imaged live cells of fruit flies in the last stages of development over several days and found a new structure that appears to help guide a section of the leg into its final shape.

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Aluminum scandium nitride thin films could pave the way for the next generation of ferroelectric memory devices, according to a new study. Compared to existing ferroelectric materials, these films maintain their ferroelectric properties and crystal structure even after heat treatment at temperatures up to 600 C in both hydrogen and argon atmospheres. This high stability makes them ideal for high-temperature manufacturing processes under the H2-included atmosphere used in fabricating advanced memory devices.

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An international team of researchers has embedded gold nanorods in hydrogels that can be processed through 3D printing to create structures that contract when exposed to light -- and expand again when the light is removed. Because this expansion and contraction can be performed repeatedly, the 3D-printed structures can serve as remotely controlled actuators.

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A group of small, freshwater animals (bdelloid rotifers) protect themselves from infections using antibiotic recipes 'stolen' from bacteria, according to new research. This raises the potential that rotifers are producing novel antimicrobials that may be less toxic to animals, including humans, than those we develop from bacteria and fungi.

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Plants and microbes are known to secrete enzymes to transform organic phosphorus into bioavailable inorganic phosphorus. Now, researchers found that iron oxide in soil performs the same transformation. Discovery is important for food security, which requires phosphorus as a crop fertilizer.

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Polyphenols are generally toxic to microorganisms. In peatlands, scientists thought microorganisms avoided this toxicity by degrading polyphenols using an oxygen-dependent enzyme, and thus that low-oxygen conditions inhibit microbes' carbon cycling. However, a new study found that Arctic peatland microorganisms used alternative enzymes, with and without oxygen, to break down polyphenols. This suggests carbon stored in these ecosystems is more at risk than previously thought.

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Researchers engineered a new technique to identify at the nanoscale level what components are overheating in electronics and causing their performance to fail.

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The human genome is filled with flecks of DNA left behind by viruses that infected primate ancestors tens of millions of years ago. Scientists used to think they were harmless, but new research shows that, when reawakened, they help cancer survive and thrive.

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High-protein diets, known as 'Paleolithic diets', are popular. Using mouse models, scientists have studied their impact. While effective in regulating weight and stabilizing diabetes, these diets are not without risks. Excess protein greatly increases ammonium production, overwhelming the liver. Excess ammonium can cause neurological disorders and, in severe cases, lead to coma. These results suggest caution when following these diets.