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Categories: Biology: Biotechnology, Chemistry: Thermodynamics
Published A new coating method in mRNA engineering points the way to advanced therapies
(via sciencedaily.com) Original source Researchers have developed a novel method of adding polyethylene glycol molecules to engineered groups of messenger RNAs called 'mRNA polyplexes', which enable the cells that receive them to produce specific proteins. This technique allows greater control of the site in the body to which the polyplexes are delivered, significantly advancing the field of therapeutic mRNA technologies, with applications in vaccine development and the treatment of cancer and other diseases.
Published Cockayne syndrome: New insights into cellular DNA repair mechanism
(via sciencedaily.com) Original source Researchers decode repair mechanism during transcription of genetic information.
Published New device gathers, stores electricity in remote settings
(via sciencedaily.com) Original source Wirelessly connected devices perform an expanding array of applications, such as monitoring the condition of machinery and remote sensing in agricultural settings. These applications hold much potential for improving the efficiency, but how do you power these devices where reliable electrical sources are not available? Research points to a possible solution in the form of a novel type of battery.
Published Machine learning method reveals chromosome locations in individual cell nucleus
(via sciencedaily.com) Original source Researchers have made a significant advancement toward understanding how the human genome is organized inside a single cell. This knowledge is crucial for analyzing how DNA structure influences gene expression and disease processes.
Published Bacteria in cancer unmasked
(via sciencedaily.com) Original source Researchers have compiled a detailed catalogue of bacteria living in cancer metastases. Having analyzed over 4000 tumors, they shed light on the diversity of these co-inhabitants and how they might interact with cancer cells and their surroundings. For example, certain bacteria were linked to a worse response to immunotherapy. This study paves the way to a better understanding of how bacteria help or hinder cancer (therapy), and how we can use this for patients' advantage.
Published New diagnostic tool achieves accuracy of PCR tests with faster and simpler nanopore system
(via sciencedaily.com) Original source A new diagnostic tool developed by researchers can test for SARS-CoV-2 and Zika virus with the same or better accuracy as high-precision PCR tests in a matter of hours.
Published Different means to the same end: How a worm protects its chromosomes
(via sciencedaily.com) Original source Researchers have discovered that a worm commonly used in the study of biology uses a set of proteins unlike those seen in other studied organisms to protect the ends of its DNA.
Published Scientists grow 'mini kidneys,' revealing new insights into metabolic defects and potential therapy for polycystic kidney disease
(via sciencedaily.com) Original source Scientists have successfully grown 'mini kidneys' in the lab and grafted them into live mice, revealing new insights into the metabolic defects and a potential therapy for polycystic kidney disease.
Published Toothed whale echolocation organs evolved from jaw muscles
(via sciencedaily.com) Original source Genetic analysis finds evidence suggesting that acoustic fat bodies in the heads of toothed whales were once the muscles and bone marrow of the jaw.
Published Proof-of-principle demonstration of 3-D magnetic recording
(via sciencedaily.com) Original source Research groups have made a breakthrough in the field of hard disk drives (HDD) by demonstrating the feasibility of multi-level recording using a three-dimensional magnetic recording medium to store digital information. The research groups have shown that this technology can be used to increase the storage capacity of HDDs, which could lead to more efficient and cost-effective data storage solutions in the future.
Published Integrated dataset enables genes-to-ecosystems research
(via sciencedaily.com) Original source A new dataset bridging molecular information about the poplar tree microbiome to ecosystem-level processes has been released. The project aims to inform research regarding how natural systems function, their vulnerability to a changing climate, and ultimately how plants might be engineered for better performance as sources of bioenergy and natural carbon storage.
Published Can language models read the genome? This one decoded mRNA to make better vaccines
(via sciencedaily.com) Original source Researchers developed a foundational language model to decode mRNA sequences and optimize those sequences for vaccine development. The tool shows broader promise as a means for studying molecular biology.
Published eDNA methods give a real-time look at coral reef health
(via sciencedaily.com) Original source The study underscores the crucial role of microbes in maintaining coral reef health, akin to the human gut microbiome. Hurricanes and disease outbreaks affect coral reef water microbial communities, leading to changes that may support further reef decline. Microbial analysis enables prompt assessment of disturbances' impacts on coral reefs, facilitating timely interventions to support reef ecosystems. Environmental DNA (eDNA) analysis offers a noninvasive approach to study coral microbial communities and diagnose reef health.
Published New tools reveal how genes work and cells organize
(via sciencedaily.com) Original source Researchers have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these protein-RNA interactions. The newfound ability to predict these interactions can help future work in understanding molecular pathways in the cell and pave the way for developing drugs targeting these RNA G-quadruplex binding proteins, that are found to be involved in disease such as cancer.
Published Giant phage holds promise as treatment for lung infections
(via sciencedaily.com) Original source Researchers have discovered a new bacterial killer that can target common lung infection caused by Burkholderia bacteria that has exciting potential for biotechnological applications.
Published Discovery could end global amphibian pandemic
(via sciencedaily.com) Original source A fungus devastating frogs and toads on nearly every continent may have an Achilles heel. Scientists have discovered a virus that infects the fungus, and that could be engineered to save the amphibians.
Published Plastic-free vegan leather that dyes itself grown from bacteria
(via sciencedaily.com) Original source Researchers have genetically engineered bacteria to grow animal- and plastic-free leather that dyes itself.
Published New discovery unravels malaria invasion mechanism
(via sciencedaily.com) Original source A recent breakthrough sheds light on how the malaria parasite, Plasmodium falciparum, invades human red blood cells. The study reveals the role of a sugar called sialic acid in this invasion process. The findings have major implications for malaria vaccine and drug development.
Published First view of centromere variation and evolution
(via sciencedaily.com) Original source A genomic study of human and selected nonhuman primate centromeres has revealed their unimaginable diversity and speed of evolutionary change. Although centromeres are vital to proper cell replication by assuring faithful transmision of genetic materials when cells divide, the complexity of their genomic organization had been almost impossible to study. The lack of centromere sequences hindered exploration of how these regions help maintain genetic integrity. Now, advanced technologies have shown scientists how greatly centromeres differ in size and structure.
Published Elastocaloric cooling: Refrigerator cools by flexing artificial muscles
(via sciencedaily.com) Original source There is room for just one small bottle in the world's first refrigerator that is cooled with artificial muscles made of nitinol, a nickel-titanium alloy. But the mini-prototype is groundbreaking: it shows that elastocalorics is becoming a viable solution for practical applications. This climate-friendly cooling and heating technology is far more energy-efficient and sustainable than current methods.