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Categories: Biology: Biotechnology, Chemistry: Thermodynamics

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Protein-splitting enzymes play an important role in many physiological processes. Such proteases are generally present in an inactive state, only becoming activated under certain conditions. Some are linked to diseases like infections or cancer, making it important to have methods that can selectively detect active proteases. Scientists have introduced a new class of protease-activity sensors: gold nanoparticles equipped with peptide DNA.

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A protein that helps generate the force needed for single cells to move works differently in cells moving in groups, a new study shows.

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Scientists have solved a decades-long puzzle and unveiled a near unbreakable substance that could rival diamond, as the hardest material on earth, a study says. Researchers found that when carbon and nitrogen precursors were subjected to extreme heat and pressure, the resulting materials -- known as carbon nitrides -- were tougher than cubic boron nitride, the second hardest material after diamond.

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A previously mysterious small RNA molecule in mice is found to play a crucial role in gene expression, and may be the first identified member of a new class of regulatory RNAs.

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Scientists have revealed a never-before-seen phenomenon in a protein: Alone, the enzyme processes DNA and RNA but, when bound to another protein as part of a defense system, interacts with a completely different type of compound to help bacteria commit suicide.

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Scientists report a new mechanism by which rotavirus induces diarrhea by interfering with the normal absorption of nutrients in the intestine.

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A fabrication process can produce self-heating microfluidic devices in one step using a multimaterial 3D printer. These devices, which can be made rapidly and cheaply in large numbers, could help clinicians in remote parts of the world detect diseases without expensive lab equipment.

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Researchers investigated the thermal energy changes across nanopores that allow the selective flow of ions. Switching off the flow of ions in one direction led to a cooling effect. The findings have applications in nanofluidic devices and provide insight into the factors governing ion channels in cells. The nanopore material could be tailored to tune the cooling and arrays could be produced to scale up the effect.

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Viruses have limited genetic material -- and few proteins -- so all the pieces must work extra hard. Zika is a great example; the virus only produces 10 proteins. Now researchers have shown how the virus does so much with so little and may have identified a therapeutic vulnerability.

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In order for immune cells to do their job, they need to know against whom they should direct their attack. Research teams a have identified new details in this process.

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The complexity of living organisms is encoded within their genes, but where do these genes come from? Researchers resolved outstanding questions regarding the origin of small regulatory genes, and described a mechanism that creates their DNA palindromes. Under suitable circumstances, these palindromes evolve into microRNA genes.

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On the highway of heat transfer, thermal energy is moved by way of quantum particles called phonons. But at the nanoscale of today's most cutting-edge semiconductors, those phonons don't remove enough heat. That's why researchers are focused on opening a new nanoscale lane on the heat transfer highway by using hybrid quasiparticles called 'polaritons.'

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A protein in the immune system programmed to protect the body from fungal infections is also responsible for exacerbating the severity of certain autoimmune diseases such as irritable bowel disease (IBS), type 1 diabetes, eczema and other chronic disorders, new research has found.  The discovery could pave the way for new and more effective drugs, without the nasty side effects of existing treatments. In addition to helping to manage severe autoimmune conditions, the breakthrough could also help treat all types of cancer.  

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Researchers have shown that an influx of water and ions into immune cells allows them to migrate to where they're needed in the body.  

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Researchers have uncovered the intricate molecular mechanism used by parasitic phytoplasma bacteria, known for inducing 'zombie-like' effects in plants.

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Researchers have discovered that electric eels can alter the genes of tiny fish larvae with their electric shock. Their findings help to better understand electroporation, a method by which genes can be transported using electricity.

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Aquaporins, which move water through membranes of plant cells, were not thought to be able to permeate sugar molecules, but researchers have observed sucrose transport in plant aquaporins for the first time, challenging this theory.

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The topic of water and the way it can move producing water droplets that leap -- propelled by surface tension -- and frost that jumps -- by way of electrostatics -- is a central focus of a group of scientists. Having incorporated the two phases of liquid and solid in the first two volumes of their research, their third volume investigates a third phase, with boiling water.

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Pregnancy brings a rise in pancreatic beta cells -- the cells that produce insulin. Shortly after birth, these cells return to their normal levels. The mechanisms behind this process had remained a mystery. But now a research group has revealed that white blood cells called macrophages 'eat' these cells. 

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Scientists have amassed genome data for dozens of 'magic mushroom' isolates and cultivars, with the goal to learn more about how their domestication and cultivation has changed them. The findings may point the way to the production of intriguing new cultivars, say the researchers.