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Categories: Biology: Biotechnology, Energy: Alternative Fuels

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A new clinical trial suggests that a combination of the drug vorinostat and immunotherapy can coax HIV-infected cells out of latency and attack them. The findings highlight how close -- yet still far -- researchers have come to developing a cure for HIV-1.

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Sandalwood oil has been used worldwide for centuries. Now, a study is the first to demonstrate in vivo the chemo-preventive properties of a by-product of the oil in a mouse model. Results show administering alpha-santalol reduced visible prostate tumors, protected the normal tissue, and delayed progression from a precancerous condition to a high-grade form of cancer. These findings are significant because mortality in prostate cancer patients is mainly attributable to advanced stages of the disease.

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The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon aging. Researchers have discovered a new mechanism of action between the nutrient adaptation of intestinal stem cells and aging. The finding may make a difference when seeking ways to maintain the functional capacity of the aging gut.

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A new 3D printing method uses ice to build a template for artificial blood vessels in engineered tissue. Researchers hope the vessels could eventually be used in artificial organ transplants or drug testing.

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Fossils of a marine animal that lived 500 million years ago, combined with computer simulations, informed the design of a new soft robot.

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Hydrogen stored in hydrogen boride sheets can be efficiently released electrochemically, report scientists. Through a series of experiments, they demonstrated that dispersing these sheets in an organic solvent and applying a small voltage is enough to release all the stored hydrogen efficiently. These findings suggest hydrogen boride sheets could soon become a safe and convenient way to store and transport hydrogen, which is a cleaner and more sustainable fuel.

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Cutting-edge research converted waste carbon dioxide into a potential precursor for chemicals and carbon-free fuel.

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Researchers have made a groundbreaking discovery: a new cell that remembers allergies.

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Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers combined multiple sequencing and experimental techniques to map the relationship between known CAD variants and the biological pathways they impact.

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Researchers have identified a new approach to controlling bacterial infections. The team found a way to turn on a vital bacterial defense mechanism to fight and manage bacterial infections. The defense system, called cyclic oligonucleotide-based antiphage signaling system (CBASS), is a natural mechanism used by certain bacteria to protect themselves from viral attacks. Bacteria self-destruct as a means to prevent the spread of virus to other bacterial cells in the population.

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A team of researchers recently published a pioneering study that answers a central question in biology: how do organisms rally a wide range of cellular processes when they encounter a change -- either internally or in the external environment -- to thrive in good times or survive the bad times? The research, focused on plants, identifies the interactions between four compounds: pectin, receptor proteins FERONIA and LLG1 and the signal RALF peptide.

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In hydrogen fuel cells, electrolyte membranes frequently undergo deformation and develop cracks during operation. A research team has recently introduced a fatigue-resistant polymer electrolyte membrane for hydrogen fuel cells, employing an interpenetrating network of Nafion (a plastic electrolyte) and perfluoropolyether (a rubbery polymer). This innovation will not only improve fuel cell vehicles but also promises advancements in diverse technologies beyond transportation, spanning applications from drones to desalination filters and backup power sources.

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Researchers have developed a new biocontainment method for limiting the escape of genetically engineered organisms used in industrial processes.

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Scientists can now predict which single-letter changes to the DNA within our genomes will alter genetic instructions and disrupt development, leading to changes such as the growth of extra digits and hearts. Such knowledge opens the door to predictions of which enhancer variants underlie disease in order to harness the full potential of our genomes for better human health.

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A recent re-emergence and outbreak of Mpox brought poxviruses back as a public health threat, underlining an important knowledge gap at their core. Now, a team of researchers lifted the mysteries of poxviral core architecture by combining various cryo-electron microscopy techniques with molecular modeling.

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A new computer program allows scientists to design synthetic DNA segments that indicate, in real time, the state of cells. It will be used to screen for anti-cancer or viral infections drugs, or to improve gene and cell-based immunotherapies.

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Switching to ammonia as a marine fuel, with the goal of decarbonization, can instead create entirely new problems. This is shown in a study where researchers carried out life cycle analyses for batteries and for three electrofuels including ammonia. Eutrophication and acidification are some of the environmental problems that can be traced to the use of ammonia -- as well as emissions of laughing gas, which is a very potent greenhouse gas.

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Scientists have found a way to boost ethanol production via yeast fermentation, a standard method for converting plant sugars into biofuels. Their approach relies on careful timing and a tight division of labor among synthetic yeast strains to yield more ethanol per unit of plant sugars than previous approaches have achieved.

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Researchers have developed a new search tool to that can match microbes to the metabolites they produce with no prior knowledge, an innovation that could transform our understanding of both human health and the environment.

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A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic approaches to treat diseases caused by faulty splicing.