Showing 20 articles starting at article 981
< Previous 20 articles Next 20 articles >
Categories: Biology: Biotechnology, Energy: Batteries
Published How superbug A. baumannii survives metal stress and resists antibiotics
(via sciencedaily.com) Original source The deadly hospital pathogen Acinetobacter baumannii can live for a year on a hospital wall without food and water. Then, when it infects a vulnerable patient, it resists antibiotics as well as the body's built-in infection-fighting response. The World Health Organization (WHO) recognizes it as one of the three top pathogens in critical need of new antibiotic therapies. Now, an international team, led by Macquarie University researchers Dr. Ram Maharjan and Associate Professor Amy Cain, have discovered how the superbug can survive harsh environments and then rebound, causing deadly infections. They have found a single protein that acts as a master regulator. When the protein is damaged, the bug loses its superpowers allowing it to be controlled, in a lab setting. The research is published this month in Nucleic Acids Research.
Published Phage structure captured, to benefit biotech applications
(via sciencedaily.com) Original source Researchers have mapped out what a commonly-used form of phage looks like, which will help design better uses in future.
Published New priming method improves battery life, efficiency
(via sciencedaily.com) Original source Engineers have developed a readily scalable method to optimize a silicon anode priming method that increases lithium-ion battery performance by 22% to 44%.
Published Researcher uses mammal DNA to zoom into the human genome with unprecedented resolution
(via sciencedaily.com) Original source Scientists have precisely identified base pairs of the human genome that remained consistent over millions of years of mammalian evolution, and which play a crucial role in human disease. The team analyzed the genomes of 240 mammals, including humans and identified base pairs that were 'constrained' -- meaning they remained generally consistent -- across mammal species over the course of evolution. The most constrained base pairs in mammals were over seven times more likely to be causal for human disease and complex trait, and over 11 times more likely when researchers looked at the most constrained base pairs in primates alone.
Published A look inside stem cells helps create personalized regenerative medicine
(via sciencedaily.com) Original source Researchers have examined a specific type of stem cell with an intracellular toolkit to determine which cells are most likely to create effective cell therapies.
Published Brain-belly connection: Gut health may influence likelihood of developing Alzheimer's
(via sciencedaily.com) Original source A new study pinpoints 10 bacterial groups associated with Alzheimer's disease, provides new insights into the relationship between gut makeup and dementia.
Published Bacteria killing material could tackle hospital superbugs
(via sciencedaily.com) Original source Researchers have used a common disinfectant and antiseptic to create a new antimicrobial coating material that effectively kills bacteria and viruses, including MRSA and SARS-COV-2.
Published Bacteria: Radioactive elements replace essential rare earth metals
(via sciencedaily.com) Original source Bacteria can use certain radioactive elements to sustain their metabolism.
Published How bacteria evolve resistance to antibiotics
(via sciencedaily.com) Original source Bacteria can rapidly evolve resistance to antibiotics by adapting special pumps to flush them out of their cells, according to new research. Antimicrobial resistance is a growing problem of global significance. The rise of resistant 'superbugs' threatens our ability to use antimicrobials like antibiotics to treat and prevent the spread of infections caused by microorganisms. It is hoped that the findings will improve how antibiotics are used to help prevent further spread of antimicrobial resistance.
Published Extending the life of a lithium metal anode using a protective layer made of an extremely tough gel electrolyte
(via sciencedaily.com) Original source A research team has succeeded in substantially improving the cycling performance of a lithium metal battery by developing a mechanically very strong polymeric gel electrolyte and integrating it into the battery as a layer to protect the lithium metal anode. This achievement may greatly facilitate efforts to put lithium metal anodes -- a potentially very high performance anode material -- into practical use.
Published Scientists create CRISPR-based drug candidate targeting the microbiome
(via sciencedaily.com) Original source A new drug candidate targeting E. coli in the gut is in phase 1 clinical trials. According to a new paper it may improve the well-being of blood cancer patients and reduce their mortality rate from E. coli infections.
Published 'Super-resolution' imaging technology
(via sciencedaily.com) Original source Researchers describe developing a super-resolution imaging platform technology to improve understanding of how nanoparticles interact within cells.
Published Scientists develop gene silencing DNA enzyme that can target a single molecule
(via sciencedaily.com) Original source Researchers have developed a DNA enzyme -- or DNAzyme -- that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough 'gene silencing' technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.
Published T cells can activate themselves to fight tumors
(via sciencedaily.com) Original source Scientists find an auto-signaling mechanism driving the T cell anti-tumor response; findings may inspire new cancer therapeutics and biomarkers.
Published New probe aids novel findings on cell functions
(via sciencedaily.com) Original source New research shows the use of a new cellular probe helped discover new findings about certain cellular processes.
Published An unprecedented view of gene regulation
(via sciencedaily.com) Original source Using a new technique, researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.
Published Tiny microbes could brew big benefits for green biomanufacturing
(via sciencedaily.com) Original source Scientists find new route in bacteria to decarbonize industry. The discovery could reduce greenhouse gas emissions from the manufacturing of fuels, drugs, and chemicals. A research team has engineered bacteria to produce new-to-nature carbon products that could provide a powerful route to sustainable biochemicals.
Published Elucidating the mysteries of enzyme evolution at the macromolecular level
(via sciencedaily.com) Original source Researchers have made a major breakthrough earlier this year in the field of evolutionary conservation of molecular dynamics in enzymes. Their work points to potential applications in health, including the development of new drugs to treat serious diseases such as cancer or to counter antibiotic resistance.
Published Scientist uncovers roots of antibiotic resistance
(via sciencedaily.com) Original source Microbiologists have uncovered the evolutionary origins of antimicrobial resistance (AMR) in bacteria. His studies on the bacterium that causes cholera, Vibrio cholerae, provide insight into deciphering what conditions must occur for infectious agents to become resistant. He studied genetic variants of a protein found in bacterial membranes called OmpU. Using computational and molecular approaches, his team found that several OmpU mutations in the cholera bacteria led to resistance to numerous antimicrobial agents. This resistance included antimicrobial peptides that act as defenses in the human gut.
Published Gutless marine worms on a Mediterranean diet: Animals can synthesize phytosterols
(via sciencedaily.com) Original source Phytosterols are good for your health, but humans and other animals are not able to make them themselves, only plants can. To acquire phytosterols, humans are increasingly turning to supplements, green smoothies, or a Mediterranean diet with plenty of plant-based foods. Researchers have now discovered that tiny gutless worms from the Mediterranean can synthesize phytosterols on their own. Their study provides evidence that many other animals also have the genes needed to make their own phytosterols.