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Categories: Biology: Biotechnology, Energy: Technology

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Scientists are investigating the previously largely unknown biosynthetic pathway that leads to the formation of cardenolides in plants. In a new study, they present two enzymes from the CYP87A family as key enzymes that catalyze the formation of pregnenolone, the precursor for the biosynthesis of plant steroids, in two different plant families. The discovery of such enzymes should help to develop platforms for the cheap and sustainable production of high quality steroid compounds for medical use.

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Researchers discover excellent thermoelectric properties of nickel-gold alloys. These can be used to efficiently convert heat into electrical energy.

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Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded 'nicks' in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.

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Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans.

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Researchers have characterized a specialized type of immune cell, which plays a key role in protecting and repairing the cells in the healthy human gut.

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Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail. By understanding how different tissues tackle protein build up, this research could accelerate the identification of ways to protect tissues that are vulnerable to protein build up, possibly tackling both disease-associated protein aggregates and also age-dependent aggregates that accelerate the functional decline of tissues.

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A research team has achieved significant breakthroughs in harnessing low-grade heat sources (<100 °C) for efficient energy conversion.

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Researchers have developed small robotic devices that can change how they move through the air by 'snapping' into a folded position during their descent. Each device has an onboard battery-free actuator, a solar power-harvesting circuit and controller to trigger these shape changes in mid-air.

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If the Chicago region replaced 30% of all on-road combustion-engine vehicles -- including motorcycles, passenger cars and trucks, buses, refuse trucks and short- and long-haul trucks -- with electric versions, it would annually save more than 1,000 lives and over $10 billion, according to a new study.

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Some crop pathogens use a clever trick to multiply and spread infection: they hijack the plant's cellular plumbing. In a new study, researchers unveil a class of bacterial proteins that fold into a straw-like shape and insert themselves into the plant cell membrane, allowing the inside of the leaf to become waterlogged. The researchers also figured out a possible way to block the water channel proteins and prevent infection.

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A new study finds that a natural compound found in many plants inhibits the growth of drug-resistant Candida fungi -- including its most virulent species, Candida auris, an emerging global health threat.

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HIV anti-retroviral therapy is considered a treatment and not a cure because patients usually carry a reservoir of HIV-infected cells that can re-emerge if treatment stops. These reservoirs have long been thought to be dormant, but two independent groups of researchers report that a subset of these cells spontaneously produce HIV RNA and proteins that may impact patients' HIV-specific immune responses.

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Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet.

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More than 400 million years ago, an insect-like animal called the springtail developed a small protein that prevents its cells from freezing.

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Increasing energy efficiency in buildings can save money -- and it can also decrease the carbon emissions and air pollution that lead to climate change and health harms. But the climate and health benefits of reducing buildings' energy consumption are rarely quantified. Now, researchers have developed a new method for calculating the health and climate impacts of these energy savings.

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Researchers are one step closer to making the T cell army stronger. In a recent study, researchers found that by manipulating one molecular signaling pathway in the T cells that participate in clearing influenza virus in the lungs, the strength and longevity of immunological memory produced can be improved.

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Researchers have unveiled an intriguing phenomenon of cellular reprogramming in mature adult organs, shedding light on a novel mechanism of adaptive growth. The study, which was conducted on fruit flies (Drosophila), provides further insights into dedifferentiation -- where specialized cells that have specific functions transform into less specialized, undifferentiated cells like stem cells.

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Researchers have developed a new imaging technique to observe active gene expression in real time. They found that four molecules work together to control the timing of each stage of the C. elegans worm's development. This timekeeping process could provide important clues about the natural rhythm of development in humans and other animals.

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In a breakthrough for the field of bioelectronics, researchers have enhanced the ability of E. coli bacteria to generate electricity. The innovative approach only offers a sustainable solution for organic waste processing while outperforming previous state-of-the-art technologies, opening new horizons for versatile microbial electricity production.

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A research team has evaluated the feasibility of ammonia-based power generation through techno-economic and carbon footprint analyses.