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Categories: Biology: Biotechnology, Engineering: Graphene

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The first stem cell culture method that produces a full model of the early stages of the human central nervous system has been developed by a team of engineers and biologists.

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Scientists have designed the first synthetic protein-based motor which harnesses biological reactions to fuel and propel itself. 'Imagine if a Roomba could be powered only by the dirt it picks up,' says one of the authors of the study. The motor uses the digestive enzyme trypsin to cut the peptides and convert them into the energy it needs to propel itself.

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Sight loss in certain inherited eye diseases may be caused by gut bacteria, and is potentially treatable by antimicrobials, finds a new study in mice.

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Resizing of the intestine is a highly conserved strategy employed by a wide range of organisms to cope with fluctuation in nutrient availability. Nevertheless, very little is known about the mechanisms and signals underlying nutrient-mediated gut resizing. New research has identified one of the signaling pathways implicated in this process.

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Iron is a micronutrient for plants. Biologists now show that regulatory proteins for iron uptake behave particularly dynamically in the cell nucleus when the cells are exposed to blue light -- an important signal for plant growth. They found that the initially homogeneously distributed proteins relocated together into 'biomolecular condensates' in the cell nucleus shortly after this exposure.

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Researchers reveal how cells regenerate protein factories at endoplasmic reticulum.

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A chemical compound essential to all living things has been synthesized in a lab in conditions that could have occurred on early Earth, suggesting it played a role at the outset of life.

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Researchers have uncovered a key link between the spread of antibiotic resistance genes and the evolution of resistance to new drugs in certain pathogens. Bacteria exposed to higher levels of antibiotics often harbor multiple identical copies of protective antibiotic resistance genes which are linked to 'jumping genes' that can move from strain to strain. Duplicate genes provide a mechanism for resistance to spread and enable evolving resistance to new drugs.

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Researchers have discovered that damage to the cell membrane promotes cellular senescence, or cell aging.

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Graphene is an enormously promising material. It consists of a single layer of carbon atoms arranged in a honeycomb pattern and has extraordinary properties: exceptional mechanical strength, flexibility, transparency and outstanding thermal and electrical conductivity. If the already two-dimensional material is spatially restricted even more, for example into a narrow ribbon, controllable quantum effects can be created. This could enable a wide range of applications, from vehicle construction and energy storage to quantum computing.

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A professor has demonstrated a connection between viral damage to the gut and premature biological aging.

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The sea lamprey, a 500-million-year-old animal with a sharp-toothed suction cup for a mouth, is the thing of nightmares. A new study discovered that the hindbrain -- the part of the brain controlling vital functions like blood pressure and heart rate -- of both sea lampreys and humans is built using an extraordinarily similar molecular and genetic toolkit.

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With ever-increasing life expectancy comes the challenge of treating age-related disorders such as osteoporosis. Although there are effective drugs for treating this metabolic bone disease, they can be expensive and have side effects, limiting their availability to some people. In the search for alternative drug candidates, researchers have discovered and fully replicated a compound from a botanical source, female ginseng, that had potent anti-osteoporotic activity in cellular tests.

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Physicists have observed fractional quantum Hall effect in simple pentalayer graphene. The finding could make it easier to develop more robust quantum computers.

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Established treatments for cancer and other diseases often focus on inhibiting harmful enzymes to mitigate their effects. However, a more innovative approach has emerged: harnessing the cell's natural waste disposal system not just to deactivate but to entirely eradicate these proteins. Researchers have previously demonstrated the efficacy of this approach through two distinct methods. Now they unveil a third system capable of targeting and disposing of previously inaccessible proteins.

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A new analysis method can detect pathogens in blood samples faster and more accurately than blood cultures, which are the current state of the art for infection diagnosis. The new method, called digital DNA melting analysis, can produce results in under six hours, whereas culture typically requires 15 hours to several days, depending on the pathogen.

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Researchers found that PD-1-enhanced DNA vaccination can induce sustained virus-specific CD8+ T cell immunity in an AIDS monkey model. The vaccinated monkeys remained free of AIDS for six years and achieved virologic control without the need for combination antiretroviral therapy (cART), a treatment used to suppress viral replication in individuals living with human immunodeficiency virus (HIV). The study also found that polyfunctional and broadly reactive effector-memory virus-specific T cells were maintained in the protected experimental macaques for over six years. The findings provide supporting evidence that the PD-1-enhanced DNA vaccine strategy holds promise as a third-generation DNA vaccine for AIDS prevention and immunotherapy.

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A pharmacy associate professor has developed a novel nanomedicine loaded with genetic material called small interfering RNAs (siRNA) to fight human immunodeficiency virus (HIV) using gene therapy.

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Researchers have developed a multipronged strategy to identify the transporters used by different drugs. Their approach, which makes use of both tissue models and machine-learning algorithms, has already revealed that a commonly prescribed antibiotic and a blood-thinner can interfere with each other.

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Researchers have found a new way to synthesize graphene oxide which has significantly fewer defects compared to materials produced by most common method. Similarly good graphene oxide could be synthesized previously only using rather dangerous method involving extremely toxic fuming nitric acid.