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Published

Unlocking the secret strength of marine mussels      (via sciencedaily.com)     Original source 

How do you create strong, yet quick-release connections between living and non-living tissues? This is a question that continues to puzzle bioengineers who aim to create materials that bond together for advanced biomedical applications. Looking to nature for inspiration, this research zeroed in on the marine mussel byssus, a fibrous holdfast, which these bivalve mollusks use to anchor themselves in seashore habitats.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Evolutionary Biology: General Biology: Microbiology Geoscience: Geochemistry
Published

Armed to the hilt: Study solves mystery behind bacteria's extensive weaponry      (via sciencedaily.com)     Original source 

A new study tackles the mystery of why bacteria often carry diverse ranges of weapons. The findings show that different weapons are best suited to different competition scenarios. Short-range weapons help bacteria to invade established communities; long-range weapons are useful once established.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Clever dosage control mechanism of biallelic genes      (via sciencedaily.com)     Original source 

Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study identified the epigenetic regulator MSL2 an 'anti-monoallelic' factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes.

Biology: Biochemistry Biology: Biotechnology Biology: Botany Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology
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Researchers decipher enzyme scissors of intestinal microbes      (via sciencedaily.com)     Original source 

Fruit and vegetables contain a variety of plant natural products such as flavonoids, which give fruits their colour and are said to have health-promoting properties. Most plant natural products occur in nature as glycosides, i.e. chemical compounds with sugars. In order for humans to absorb the healthy plant natural products, the sugar must be split off in the intestine. Microorganisms in the intestinal flora help to speed up the process. So-called C-glycosides, i.e. plant natural products with a carbon-based bond to a sugar, would even be practically indigestible without the intestinal microbes (e.g. nothofagin in rooibos tea).

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Chemistry: Biochemistry Chemistry: Organic Chemistry
Published

Releasing brakes on biocatalysis      (via sciencedaily.com)     Original source 

Enzymes from microorganisms can produce hydrogen (H2) under certain conditions, which makes them potential biocatalysts for biobased H2 technologies. In order to make this hydrogen production efficient, researchers are trying to identify and eliminate possible limiting factors. These include formaldehyde, which occurs naturally as a metabolic product in cells and inhibits the particularly efficient [FeFe] hydrogenase.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: Evolutionary Biology: General Biology: Genetics Biology: Microbiology
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Tracing the evolution of the 'little brain'      (via sciencedaily.com)     Original source 

The evolution of higher cognitive functions in humans has so far mostly been linked to the expansion of the neocortex. Researchers are increasingly realizing, however, that the 'little brain' or cerebellum also expanded during evolution and probably contributes to the capacities unique to humans. A research team has now generated comprehensive genetic maps of the development of cells in the cerebella of human, mouse and opossum. Comparisons of these maps reveal both ancestral and species-specific cellular and molecular characteristics of cerebellum development.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Microbiology
Published

Nano-sized cell particles are promising intervention tool in treating infectious diseases      (via sciencedaily.com)     Original source 

Extracellular vesicles were found to inhibit the viral infection of COVID-19 and potentially other infectious diseases.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Microbiology Biology: Molecular
Published

New clues into the head-scratching mystery of itch      (via sciencedaily.com)     Original source 

Scientists show for the first time that bacteria can cause itch by activating nerve cells in the skin. The findings can inform new therapies to treat itch that occurs in inflammatory skin conditions like eczema and dermatitis.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Molecular
Published

Nutrient found in beef and dairy improves immune response to cancer      (via sciencedaily.com)     Original source 

Trans-vaccenic acid (TVA), a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep, improves the ability of CD8+ T cells to infiltrate tumors and kill cancer cells, according to a new study.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Team discovers rules for breaking into Pseudomonas      (via sciencedaily.com)     Original source 

Researchers report that they have found a way to get antibacterial drugs through the nearly impenetrable outer membrane of Pseudomonas aeruginosa, a bacterium that -- once it infects a person -- is notoriously difficult to treat.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Laser-powered 'tweezers' reveal universal mechanism viruses use to package up DNA      (via sciencedaily.com)     Original source 

Researchers have used laser-powered ‘optical tweezers’ to reveal a universal motor mechanism used by viruses for packaging their DNA into infectious particles.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Microbiology
Published

Researchers shed light on how one deadly pathogen makes its chemicals      (via sciencedaily.com)     Original source 

Investigators have played a key role in deciphering a previously unidentified cluster of genes responsible for producing sartorypyrones, a chemical made by the fungal pathogen Aspergillus fumigatus, whose family causes Aspergillosis in humans.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Offbeat: General Offbeat: Plants and Animals
Published

Unearthing how a carnivorous fungus traps and digests worms      (via sciencedaily.com)     Original source 

A new analysis sheds light on the molecular processes involved when a carnivorous species of fungus known as Arthrobotrys oligospora senses, traps and consumes a worm.

Biology: Biochemistry Biology: Biotechnology Biology: General
Published

New approaches in the fight against drug resistance in malaria      (via sciencedaily.com)     Original source 

Malaria is one of the most widespread and deadly infectious diseases worldwide. New compounds are continuously required due to the risk of malaria parasites becoming resistant to the medicines currently used. A team of researchers has now combined the anti-malaria drug artemisinin with coumarin, which, like artemisinin, is also found in plants, and developed an auto-fluorescent compound from both bioactive substances.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Evolutionary Biology: General Biology: Genetics Biology: Zoology Ecology: Nature Geoscience: Geography
Published

Scientists have solved the damselfly color mystery      (via sciencedaily.com)     Original source 

For over 20 years, a research team has studied the common bluetail damselfly. Females occur in three different color forms -- one with a male-like appearance, something that protects them from mating harassment. In a new study, an international research team found that this genetic color variation that is shared between several species arose through changes in a specific genomic region at least five million years ago.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Heart repair via neuroimmune crosstalk      (via sciencedaily.com)     Original source 

Unlike humans, zebrafish can completely regenerate their hearts after injury. They owe this ability to the interaction between their nervous and immune systems, as researchers now report.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Molecular
Published

New method to help with analysis of single cell data      (via sciencedaily.com)     Original source 

CITE-seq (cellular indexing of transcriptomes and epitopes) is an RNA sequencing-based method that simultaneously quantifies cell surface protein and transcriptomic data within a single cell readout. The ability to study cells concurrently offers unprecedented insights into new cell types, disease states or other conditions.   While CITE-seq solves the problem of detecting a limited number of proteins while using single-cell sequencing in an unbiased way, one of its limitations is the high levels of background noise that can hinder analysis.