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Categories: Biology: Biotechnology, Engineering: Nanotechnology
Published Discovery of vast sex differences in cellular activity has major implications for disease treatment
(via sciencedaily.com) Original source The study reveals vast differences in gene activity within the mitochondria of males compared to females. This is the first study to test effects of all 37 genes in the mitochondrial genome -- genes that copepods and humans share. The study found that males demonstrate more activity across all protein-coding mitochondrial genes than females. Although the study looks at tiny marine organisms called copepods, the findings have weighty implications for human medicine.
Published Removal of excess chloride ions by plants when subjected to salt stress
(via sciencedaily.com) Original source Researchers have discovered a salt adaptation mechanism in plants that facilitates chloride removal from the roots and enhancing salinity tolerance. A research team has uncovered a novel mechanism of plant adaptation to salt stress involving the NaCl-induced translocation of a specific chloride channel protein, AtCLCf.
Published How cells boost gene expression
(via sciencedaily.com) Original source The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins -- yet it exists in large quantities. A research team has now discovered an important function of antisense RNA (asRNA): the researchers found that asRNA acts as a 'superhighway' in cell transport and thus accelerates gene expression.
Published How to make aging a 'fairer game' for all wormkind
(via sciencedaily.com) Original source Researchers have discovered a new fundamental mechanism governing the rules of ageing in worms. The researchers were able to manipulate the mechanism through genetic interventions which dramatically extend not just the lifespan of the worms, but also their health-span. In other words, trading weak, frail old age with vigorous golden years -- all without altering their diet, environment or other external factors.
Published Odors are encoded in rings in the brain of migratory locusts
(via sciencedaily.com) Original source Researchers describe how odors are encoded in the antennal lobe, the olfactory center in the brain of migratory locusts. Using transgenic locusts and imaging techniques, the researchers were able to show a ring-shaped representation of odors in the brain. The pattern of olfactory coding in the antennal lobe is the same at all stages of locust development. A better understanding of olfactory coding in the locust brain should help to learn more about how the behavior of these insects is controlled, especially their swarming.
Published Researchers film energy materials as they form
(via sciencedaily.com) Original source Shooting a movie in the lab requires special equipment. Especially when the actors are molecules -- invisible to the naked eye -- reacting with each other. 'Imagine trying to film tiny lava flows during a volcanic eruption. Your smartphone camera wouldn't be up to the job.
Published Where to put head and tail?
(via sciencedaily.com) Original source Formation of the body axes is a critical part of embryonic development. They guarantee that all body parts end up where they belong and that no ears grow on our backs. The head-tail axis, for example, determines the orientation of the two ends of the body. It was previously assumed that this axis is largely determined by the interplay between the Nodal and BMP signals. However, there appears to be another player in this system, as researchers have now discovered by using an embryo-like model system they developed. In the absence of BMP, the signalling molecule beta-catenin takes on the role of the Nodal antagonist. This new mechanism could be a flexible solution for axis formation in embryos with different shapes.
Published Novel method for measuring nano/microplastic concentrations in soil using spectroscopy
(via sciencedaily.com) Original source Current techniques for measuring nano/microplastic (N/MP) concentrations in soil require the soil organic matter content to be separated and have limited resolution for analyzing N/MPs sized <1 m. Therefore, researchers have developed a novel yet simple method to measure N/MP concentration in different soil types using spectroscopy at two wavelengths. This method does not require the soil to be separated in order to detect the N/MPs and can accurately quantify N/MPs regardless of their size.
Published Golden ball mills as green catalysts
(via sciencedaily.com) Original source A gold-coated milling vessel for ball mills proved to be a real marvel: without any solvents or environmentally harmful chemicals, the team was able to use it to convert alcohols into aldehydes. The catalytic reaction takes place at the gold surface and is mechanically driven. The vessel can be reused multiple times. 'This opens up new prospects for the use of gold in catalysis and shows how traditional materials can contribute to solving modern environmental problems in an innovative way,' says Borchardt.
Published Nano-immunotherapy developed to improve lung cancer treatment
(via sciencedaily.com) Original source Researchers have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system's ability to fight cancer. The team showed promising results for the new therapy in cancer cells in the lab and in mouse lung tumor models, with potential applications for improving care and outcomes for patients with tumors that have failed to respond to traditional immunotherapy.
Published Vitamin B6: New compound delays degradation
(via sciencedaily.com) Original source A low vitamin B6 level has negative effects on brain performance. A research team has now found a way to delay the degradation of the vitamin.
Published The genetic 'switches' of bone growth
(via sciencedaily.com) Original source In mammals, only 3% of the genome consists of coding genes which, when transcribed into proteins, ensure the biological functions of the organism and the in-utero development of future individuals. But genes do not function alone. They are controlled by other sequences in the genome, called enhancers, which, like switches, activate or deactivate them as required. A team has now identified and located 2700 enhancers -- among millions of non-coding genetic sequences -- that precisely regulate the genes responsible for bone growth. This discovery sheds light on one of the major factors influencing the size of individuals in adulthood, and explains why their failure could be the cause of certain bone malformations.
Published Self-assembling and disassembling swarm molecular robots via DNA molecular controller
(via sciencedaily.com) Original source Researchers have succeeded in developing a DNA-based molecular controller. Crucially, this controller enables the autonomous assembly and disassembly of molecular robots, as opposed to manually directing it.
Published Scientists preserve DNA in an amber-like polymer
(via sciencedaily.com) Original source With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.
Published Modifying genomes of tardigrades to unravel their secrets
(via sciencedaily.com) Original source Some species of tardigrades are highly and unusually resilient to various extreme conditions fatal to most other forms of life. The genetic basis for these exceptional abilities remains elusive. Researchers have now successfully edited genes using the CRISPR technique in a highly resilient tardigrade species previously impossible to study with genome-editing tools. The successful delivery of CRISPR to an asexual tardigrade species directly produces gene-edited offspring. The design and editing of specific tardigrade genes allow researchers to investigate which are responsible for tardigrade resilience and how such resilience can work.
Published Nanosized blocks spontaneously assemble in water to create tiny floating checkerboards
(via sciencedaily.com) Original source Researchers have engineered nanosized cubes that spontaneously form a two-dimensional checkerboard pattern when dropped on the surface of water. The work presents a simple approach to create complex nanostructures through a technique called self-assembly.
Published Swimming microrobots deliver cancer-fighting drugs to metastatic lung tumors in mice
(via sciencedaily.com) Original source Engineers have developed microscopic robots, known as microrobots, capable of swimming through the lungs to deliver cancer-fighting medication directly to metastatic tumors. This approach has shown promise in mice, where it inhibited the growth and spread of tumors that had metastasized to the lungs, thereby boosting survival rates compared to control treatments.
Published Quantum dots and metasurfaces: Deep connections in the nano world
(via sciencedaily.com) Original source A team has developed printable, highly efficient light-emitting metasurfaces.
Published Uncovering the nature of emergent magnetic monopoles
(via sciencedaily.com) Original source To understand the unique physical phenomena associated with the properties of magnetic hedgehogs and antihedgehogs, which behave as virtual magnetic monopoles and antimonopoles respectively, it is essential to study their intrinsic excitations. In a new study, researchers revealed the dynamical nature of collective excitation modes in hedgehog lattices in itinerant chiral magnets. Their findings serve as the foundation for studying the dynamics of emergent magnetic monopoles in magnets.
Published New technique reveals earliest signs of genetic mutations
(via sciencedaily.com) Original source Mutations are changes in the molecular 'letters' that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including cancer. Now, a new study introduces an original technique, called HiDEF-seq, that can accurately detect the early molecular changes in DNA code that precede mutations.