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Categories: Biology: Biotechnology, Computer Science: Artificial Intelligence (AI)
Published Can language models read the genome? This one decoded mRNA to make better vaccines
(via sciencedaily.com) Original source Researchers developed a foundational language model to decode mRNA sequences and optimize those sequences for vaccine development. The tool shows broader promise as a means for studying molecular biology.
Published eDNA methods give a real-time look at coral reef health
(via sciencedaily.com) Original source The study underscores the crucial role of microbes in maintaining coral reef health, akin to the human gut microbiome. Hurricanes and disease outbreaks affect coral reef water microbial communities, leading to changes that may support further reef decline. Microbial analysis enables prompt assessment of disturbances' impacts on coral reefs, facilitating timely interventions to support reef ecosystems. Environmental DNA (eDNA) analysis offers a noninvasive approach to study coral microbial communities and diagnose reef health.
Published New privacy-preserving robotic cameras obscure images beyond human recognition
(via sciencedaily.com) Original source In a bid to restore privacy, researchers have created a new approach to designing cameras that process and scramble visual information before it is digitized so that it becomes obscured to the point of anonymity.
Published New tools reveal how genes work and cells organize
(via sciencedaily.com) Original source Researchers have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these protein-RNA interactions. The newfound ability to predict these interactions can help future work in understanding molecular pathways in the cell and pave the way for developing drugs targeting these RNA G-quadruplex binding proteins, that are found to be involved in disease such as cancer.
Published Giant phage holds promise as treatment for lung infections
(via sciencedaily.com) Original source Researchers have discovered a new bacterial killer that can target common lung infection caused by Burkholderia bacteria that has exciting potential for biotechnological applications.
Published Discovery could end global amphibian pandemic
(via sciencedaily.com) Original source A fungus devastating frogs and toads on nearly every continent may have an Achilles heel. Scientists have discovered a virus that infects the fungus, and that could be engineered to save the amphibians.
Published Plastic-free vegan leather that dyes itself grown from bacteria
(via sciencedaily.com) Original source Researchers have genetically engineered bacteria to grow animal- and plastic-free leather that dyes itself.
Published New discovery unravels malaria invasion mechanism
(via sciencedaily.com) Original source A recent breakthrough sheds light on how the malaria parasite, Plasmodium falciparum, invades human red blood cells. The study reveals the role of a sugar called sialic acid in this invasion process. The findings have major implications for malaria vaccine and drug development.
Published First view of centromere variation and evolution
(via sciencedaily.com) Original source A genomic study of human and selected nonhuman primate centromeres has revealed their unimaginable diversity and speed of evolutionary change. Although centromeres are vital to proper cell replication by assuring faithful transmision of genetic materials when cells divide, the complexity of their genomic organization had been almost impossible to study. The lack of centromere sequences hindered exploration of how these regions help maintain genetic integrity. Now, advanced technologies have shown scientists how greatly centromeres differ in size and structure.
Published These plants evolved in Florida millions of years ago: They may be gone in decades
(via sciencedaily.com) Original source Scrub mints are among the most endangered plants you've probably never heard of. More than half of the 24 species currently known to exist are considered threatened or endangered at the state or federal level. In a new study, researchers show there are likely more scrub mint species waiting to be scientifically described. And at least one species has been left without federal protection because of a technicality.
Published New method reveals hidden activity of life below ground
(via sciencedaily.com) Original source Researchers have refined an innovative method for measuring the activity level of microbes and linking that to their individual genetic code, providing new insights into the microbial communities that thrive in extreme environments.
Published New antibiotic class effective against multidrug-resistant bacteria
(via sciencedaily.com) Original source Scientists have discovered a new class of antibiotics with potent activity against multi-drug resistant bacteria, and have shown that it cures bloodstream infections in mice. Two publicly-funded initiatives dedicated to advancing early-stage antibiotic development, ENABLE and ENABLE-2, provided the resources and expert support without which this antibiotic would not have been developed.
Published Pilot study shows ketogenic diet improves severe mental illness
(via sciencedaily.com) Original source A small clinical trial found that the metabolic effects of a ketogenic diet may help stabilize the brain.
Published When inequality is more than 'skin-deep': Social status leaves traces in the epigenome of spotted hyenas in Tanzania
(via sciencedaily.com) Original source A research consortium provides evidence that social behavior and social status are reflected at the molecular level of gene activation (epigenome) in juvenile and adult free-ranging spotted hyenas. They analyzed non-invasively collected gut epithelium samples from both high-ranking and low-ranking female hyenas and showed that rank differences were associated with epigenetic signatures of social inequality, i.e., the pattern of activation or switching off of genes that regulate important physiological processes such as energy conversion and immune response in several genome regions.
Published How the Crimean-Congo hemorrhagic fever virus enters our cells
(via sciencedaily.com) Original source Researchers have identified how the tick-borne Crimean-Congo haemorrhagic fever virus enters our cells. The results are an important step in the development of drugs against the deadly disease.
Published Genomic research may help explain cancer resistance in Tasmanian devils
(via sciencedaily.com) Original source Through DNA sequencing of Tasmanian devils and their tumors, researchers have tracked the genomic interactions between the animals and the cancer.
Published Researchers discover key gene for toxic alkaloid in barley
(via sciencedaily.com) Original source Barley is one of the most important cereal crops on a global scale. Many barley cultivars produce a toxic alkaloid called gramine that affects the suitability of barley as fodder, but also helps to protect barley from pathogens. So far, the potential of manipulating gramine levels has not been harnessed for plant breeding, because the genetic basis of gramine production has been unresolved. Research groups now disclose the complete biosynthetic pathway of gramine and demonstrate how gramine biosynthesis can be introduced into model organisms or removed from barley.
Published Connecting the dots to shape growth forces
(via sciencedaily.com) Original source Branching patterns are prevalent in our natural environment and the human body, such as in the lungs and kidneys. For example, specific genes that express growth factor proteins are known to influence the development of the lungs' complex branches. Researchers have unveiled a regulatory system linking signal, force, and shape in mouse lung structure development. The team recognized that the signal protein ERK plays an active role in causing growing lung tissue to curve.
Published Synaptic protein change during development offers clues on evolution and disease
(via sciencedaily.com) Original source An analysis of how synaptic proteins change during early development reveals differences between mice and marmosets but also what's different in individuals with autism spectrum disorders. The findings offer first insights into the mechanism behind synaptic development and open up routes for research on possible treatments.
Published Revolutionary biomimetic olfactory chips to enable advanced gas sensing and odor detection
(via sciencedaily.com) Original source A research team has addressed the long-standing challenge of creating artificial olfactory sensors with arrays of diverse high-performance gas sensors. Their newly developed biomimetic olfactory chips (BOC) are able to integrate nanotube sensor arrays on nanoporous substrates with up to 10,000 individually addressable gas sensors per chip, a configuration that is similar to how olfaction works for humans and other animals.