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Categories: Biology: Biotechnology, Computer Science: Artificial Intelligence (AI)
Published New reasons eating less fat should be one of your resolutions
(via sciencedaily.com) Original source A new study to motivate your New Year's resolutions: it demonstrates that high-fat diets negatively impact genes linked not only to obesity, colon cancer and irritable bowels, but also to the immune system and brain function.
Published Big impacts from small changes in cell
(via sciencedaily.com) Original source Tiny things matter -- for instance, one amino acid can completely alter the architecture of the cell. Researchers have now investigated the structure and mechanics of the main component of the cytoskeleton of the cell: a protein known as actin. Actin is found in all living cells where it has a range of important functions -- from muscle contraction to cell signalling and cell shape. This protein comes in two different varieties termed 'isoforms', which are known as gamma actin and beta actin.
Published How jellyfish regenerate functional tentacles in days
(via sciencedaily.com) Original source At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days -- but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage. Jellyfish, along with other cnidarians such as corals and sea anemones, exhibit high regeneration abilities, but how they form the critical blastema has remained a mystery until now.
Published Researchers map how measles virus spreads in human brain
(via sciencedaily.com) Original source Researchers mapped how the measles virus mutated and spread in the brain of a person who succumbed to a rare, lethal brain disease. New cases of this disease, which is a complication of the measles virus, may occur as measles reemerges among the unvaccinated, say researchers.
Published GPCR structure: Research reveals molecular origins of function for a key drug target
(via sciencedaily.com) Original source Scientists reveal how G protein-coupled receptors, major therapeutic drug targets, decode critical properties of their ligands.
Published New tool unifies single-cell data
(via sciencedaily.com) Original source A new methodology that allows for the categorization and organization of single-cell data has been launched. It can be used to create a harmonized dataset for the study of human health and disease.
Published Location, location, location: The hidden power of intracellular neighborhoods
(via sciencedaily.com) Original source New findings provide details about the hidden organization of the cytoplasm, showing it makes a big difference where in that cellular broth that messenger RNA (mRNA) get translated into proteins. The findings hold promise for increasing or altering the production of proteins in mRNA vaccines and therapies.
Published The future of canine stem cell therapy: unprecedented, painless, and feeder-free
(via sciencedaily.com) Original source Scientists have developed an efficient, non-invasive, and pain-free method to generate canine-induced pluripotent stem cells (iPSCs). They identified six reprogramming genes that can boost canine iPSC generation by 120 times compared to conventional methods using fibroblasts. The iPSCs were created from urine-derived cells without the need for feeder cells, an impossible feat until now. Their findings are expected to advance regenerative medicine and genetic disease research in veterinary medicine.
Published The key mechanism to cell growth has been elucidated
(via sciencedaily.com) Original source Researchers have discovered how amino acids activate a key cell, TORC1, which is a master regulator in living organisms that controls whether cells grow or recycle their contents in yeast. Notably, the team found that the amino acid cysteine is sensed by a protein called Pib2 and that the two bind together to trigger TORC1. This is important because faulty TORC1 has been linked to disease such as cancer.
Published Bugs that help bugs: How environmental microbes boost fruit fly reproduction
(via sciencedaily.com) Original source A research group found that in female fruit flies, microorganisms enhance reproductive function, boosting the number of cells that form eggs and the number of mature eggs. This is done by controlling the release of hormones to speed up cell division in the ovaries, and limiting programmed cell death. These findings could improve reproductive medicine and could aid the development of new methods to enhance fertility.
Published Researchers solve mystery behind DnaA protein's role in DNA replication initiation
(via sciencedaily.com) Original source Scientists have uncovered how DnaA, the master key to DNA replication, opens the door to bacterial growth. This breakthroughpaves the way for new antibiotics to combat the rising tide of antibiotic resistance.
Published New insights revealed on tissue-dependent roles of JAK signaling in inflammation
(via sciencedaily.com) Original source Researchers have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues.
Published How researchers are 'CReATiNG' synthetic chromosomes faster and cheaper
(via sciencedaily.com) Original source A new technique to clone and reassemble DNA, dubbed CReATiNG, could simplify and lower the cost to make synthetic chromosomes. Potential applications are numerous, including pharmaceutical production, biofuel generation, cancer therapies, and environmental cleanup using modified organisms. The method adds a powerful, versatile tool to the burgeoning field of synthetic biology.
Published Discovery: Plants use 'Trojan horse' to fight mold invasions
(via sciencedaily.com) Original source Scientists have discovered that plants send tiny, innocuous-seeming lipid 'bubbles' filled with RNA across enemy lines, into the cells of the aggressive mold. Once inside, different types of RNA come out to suppress the infectious cells that sucked them in.
Published AI alters middle managers' work
(via sciencedaily.com) Original source The introduction of artificial intelligence is a significant part of the digital transformation bringing challenges and changes to the job descriptions among management. A study shows that integrating artificial intelligence systems into service teams increases demands imposed on middle management in the financial services field. In that sector, the advent of artificial intelligence has been fast and AI applications can implement a large proportion of routine work that was previously done by people. Many professionals in the service sector work in teams which include both humans and artificial intelligence systems, which sets new expectations on interactions, human relations, and leadership.
Published A trillion scents, one nose
(via sciencedaily.com) Original source A research team has uncovered a previously undetected mechanism in mice -- starring the genetic molecule RNA -- that could explain how each sensory cell, or neuron, in mammalian noses becomes tailored to detect a specific odor chemical.
Published Meet 'Coscientist,' your AI lab partner
(via sciencedaily.com) Original source An artificial intelligence-driven system has autonomously learned about certain Nobel Prize-winning chemical reactions and designed a successful laboratory procedure to make them. The AI did so in just a few minutes and correctly on its first attempt. According to the authors, this is the first time that a non-organic intelligence planned, designed and executed this complex reaction that was invented by humans.
Published Cells of the future: A key to reprogramming cell identities
(via sciencedaily.com) Original source The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time. Scientists have recently uncovered a fascinating aspect of this process known as 'replication timing' (RT) and how special this is when life commences.
Published Multitasking microbes: Scientists engineer bacteria to make two valuable products from plant fiber
(via sciencedaily.com) Original source Researchers have engineered bacteria that can produce two chemical products at the same time from underutilized plant fiber. And unlike humans, these multitasking microbes can do both things equally well. The discovery could help make biofuels more sustainable and commercially viable.
Published New study examines the relationship between the rate of wound healing, the circadian rhythm, and 'hair' on cells
(via sciencedaily.com) Original source Nearly every organism on Earth follows a natural circadian rhythm that is coded by your cell's clock genes, which do exactly as you suspect from the name: regulate your body's rhythm on a 24-hour basis. Most cells in mammalian bodies have cilia of some sort, which are hair-like structures that perform a variety of functions such as movement for motile cilia and aiding in structure in function for non-motile, or primary, cilia. The primary cilia also act as a sensory organ for the cell, a function which has illuminated the primary cilia's potential role in the healing process and how bodies heal at a different rate according to our circadian rhythm. In this research, the role of the primary cilia, biological clock and wound healing is explored.