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Categories: Biology: Biotechnology, Mathematics: Puzzles
Published Unraveling the connections between the brain and gut
(via sciencedaily.com) Original source Engineers designed a technology to probe connections between the brain and the digestive tract. Using fibers embedded with a variety of sensors, as well as optogenetic stimulation, the researchers could control neural circuits connecting the gut and the brain, in mice.
Published A roadmap for gene regulation in plants
(via sciencedaily.com) Original source For the first time, researchers have developed a genome-scale way to map the regulatory role of transcription factors, proteins that play a key role in gene expression and determining a plant's physiological traits. Their work reveals unprecedented insights into gene regulatory networks and identifies a new library of DNA parts that can be used to optimize plants for bioenergy and agriculture.
Published Now, every biologist can use machine learning
(via sciencedaily.com) Original source Scientists have built a new, comprehensive AutoML platform designed for biologists with little to no ML experience. New automated machine learning platform enables easy, all-in-one analysis, design, and interpretation of biological sequences with minimal coding. Their platform, called BioAutoMATED, can use sequences of nucleic acids, peptides, or glycans as input data, and its performance is comparable to other AutoML platforms while requiring minimal user input.
Published DNA can fold into complex shapes to execute new functions
(via sciencedaily.com) Original source DNA can mimic protein functions by folding into elaborate, three-dimensional structures, according to a new study.
Published Researchers reveal mechanism of protection against breast and ovarian cancer
(via sciencedaily.com) Original source Researchers have outlined the structure and function of a protein complex which is required to repair damaged DNA and protect against cancer.
Published Scientists discover new embryonic cell type that self-destructs to protect the developing embryo
(via sciencedaily.com) Original source Scientists have uncovered a new quality control system that removes damaged cells from early developing embryos.
Published The speed of life: A zoo of cells to study developmental time
(via sciencedaily.com) Original source Researchers have used an unprecedented stem cell zoo to compare six different mammalian species and their developmental time.
Published Cryo conservation: A cool solution to saving species from extinction
(via sciencedaily.com) Original source In the face of the biodiversity crisis, and alarming data showing a 69% decline in global animal populations since 1970, researchers are banking on a cool solution to help save species from extinction. Much like egg-freezing is used to preserve human fertility options for a later date, the cryo-freezing of genetic samples taken from animals may play an essential role in curbing species extinctions. A new study sheds light on the immense potential of living cell banks, also known as cryobanks, to contribute to global conservation priorities.
Published A new tool to study complex genome interactions
(via sciencedaily.com) Original source Genome Architecture Mapping captures complex, multi-way interactions in the genome. This is different than the workhorse technique of 3D genomics, which sees mostly two-way contacts, finds a new study.
Published Tethering of shattered chromosomal fragments paves way for new cancer therapies
(via sciencedaily.com) Original source Scientists discover shattered chromosomal fragments are tethered together during cell division before being rearranged; destroying the tether may help prevent cancerous mutations.
Published Close up on aging reveals how different cell types in the body age at different pace
(via sciencedaily.com) Original source A team or researchers reports the first Aging Fly Cell Atlas (AFCA), a detailed characterization of the aging process in 163 distinct cell types in the laboratory fruit fly. Their in-depth analysis revealed that different cell types in the body age differently, each cell type following a process involving cell type-specific patterns. AFCA provides a valuable resource for researchers in the fruit fly and aging communities as a reference to study aging and age-related diseases and to evaluate the success of anti-aging strategies.
Published Scientists discover small RNA that regulates bacterial infection
(via sciencedaily.com) Original source Researchers have identified the major mechanism behind the transition between chronic and acute P. aeruginosa infections. Their research findings can inform the development of future treatments for life-threatening acute infections.
Published Scientists investigate the evolution of animal developmental mechanisms, show how some of Earth's earliest animals evolved
(via sciencedaily.com) Original source Lacking bones, brains, and even a complete gut, the body plans of simple animals like sea anemones appear to have little in common with humans and their vertebrate kin. Nevertheless, new research shows that appearances can be deceiving, and that a common genetic toolkit can be deployed in different ways to drive embryological development to produce very different adult body plans. It is well established that sea anemones, corals, and their jellyfish relatives shared a common ancestor with humans that plied the Earth's ancient oceans over 600 million years ago. A new study from the Gibson Lab, published in Current Biology on June 13, 2023, illuminates the genetic basis for body plan development in the starlet sea anemone, Nematostella vectensis. This new knowledge paints a vivid picture of how some of the earliest animals on earth progressed from egg to embryo to adult.
Published CRISPR/Cas9-based gene drive could suppress agricultural pests
(via sciencedaily.com) Original source Researchers have now used a gene-drive system to suppress an important agricultural pest.
Published Taurine may be a key to longer and healthier life
(via sciencedaily.com) Original source A study finds that deficiency of taurine, a molecule produced in our bodies, drives aging, and taurine supplements can improve health and increase lifespan in animals.
Published When water temperatures change, the molecular motors of cephalopods do too
(via sciencedaily.com) Original source Working with live squid hatchlings, scientists find the animals can tune their proteome on the fly in response to changes in ocean temperature via the unique process of RNA recoding. The findings inspire new questions about basic protein function.
Published Octopuses rewire their brains to adapt to seasonal temperature shifts
(via sciencedaily.com) Original source Octopuses don't thermoregulate, so their powerful brains are exposed to -- and potentially threatened by -- changes in temperature. Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions. The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins. This rewiring likely protects their brains, and the researchers suspect that this unusual strategy is used widely amongst octopuses and squid.
Published Remains of an extinct world of organisms discovered
(via sciencedaily.com) Original source Newly discovered biomarker signatures point to a whole range of previously unknown organisms that dominated complex life on Earth about a billion years ago. They differed from complex eukaryotic life as we know it, such as animals, plants and algae in their cell structure and likely metabolism, which was adapted to a world that had far less oxygen in the atmosphere than today.
Published Biological clocks of people and malaria parasites tick in tune
(via sciencedaily.com) Original source Could the next weapon against malaria come from a better understanding of biological clocks? A new study shows that malaria parasites sync their gene activity with the circadian rhythms of their host, like two pendulum clocks with synchronized swings. If scientists can identify the molecular signals behind this mysterious synchronicity, they might be able to develop new anti-malarial drugs that throw malaria's internal clock out of step with its host, essentially 'jet-lagging' the parasites.
Published Older trees accumulate more mutations than their younger counterparts
(via sciencedaily.com) Original source A study of the relationship between the growth rate of tropical trees and the frequency of genetic mutations they accumulate suggests that older, long-lived trees play a greater role in generating and maintaining genetic diversity than short-lived trees.