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Categories: Biology: Biotechnology, Ecology: General
Published Novel genome editing approach restores hearing in adult preclinical models with genetic deafness
(via sciencedaily.com) Original source Researchers restored hearing in preclinical mouse models with a specific form of inherited deafness called DFNA50 caused by mutations in microRNA, by using a novel in vivo CRISPR genome editing approach. Since mouse and human microRNAs have identical sequences, the researchers hope this work can one day be translated into applications for humans.
Published Atlas of proteins reveals inner workings of cells
(via sciencedaily.com) Original source Researchers discover how proteins behave inside cells using AI, which has the potential to guide drug design.
Published Phage-derived enzyme targets E. faecalis biofilms to mitigate acute graft-versus-host disease
(via sciencedaily.com) Original source Acute graft-versus-host disease occurs when donor immune cells attack the recipient's tissues after an allogeneic hematopoietic stem cell transplantation (allo-HCT). Researchers recently identified a bacteriophage-derived enzyme called endolysin capable of targeting biofilms formed by Enterococcus faecalis. Their findings offer hope for tailored interventions in allo-HCT.
Published Discovery could help reduce adverse side effects of popular next-generation obesity medications
(via sciencedaily.com) Original source By teasing apart the therapeutic benefits from the adverse effects of new generation obesity medications, researchers found a population of neurons in the brain that controls food intake without causing nausea in an animal model.
Published Big gain in battle against harmful bacteria
(via sciencedaily.com) Original source An unexpected find has enabled important progress to be made in the battle against harmful bacteria.
Published The plague may have caused the downfall of the Stone Age farmers
(via sciencedaily.com) Original source Ancient DNA from bones and teeth hints at a role of the plague in Stone Age population collapse. Contrary to previous beliefs, the plague may have diminished Europe's populations long before the major plague outbreaks of the Middle Ages, new research shows.
Published New one-step method to make multiple edits to a cell's genome
(via sciencedaily.com) Original source A team of scientists have developed a new method that enables them to make precise edits in multiple locations within a cell -- all at once. Using molecules called retrons, they created a tool that can efficiently modify DNA in bacteria, yeast, and human cells.
Published Global database reveals large gaps in our knowledge of four-footed animals
(via sciencedaily.com) Original source Researchers developed TetrapodTraits -- a global database of animals with four feet -- which can now be applied for better ecology, evolution and conservation research.
Published Whale remains tracked to highlight sustainable disposal benefits
(via sciencedaily.com) Original source A new study highlights the sustainable, cultural and ecosystem benefits of offshore removal or decomposition of whale remains. The study tracked the remains of a humpback whale that was intercepted before washing up on the shoreline, then repositioned 30km offshore and fitted with a satellite tag that tracked its position as it drifted with the wind and currents for 6 days before falling to the seabed.
Published How a plant app helps identify the consequences of climate change
(via sciencedaily.com) Original source A research team has developed an algorithm that analyses observational data from a plant identification app. The novel approach can be used to derive ecological patterns that could provide valuable information about the effects of climate change on plants.
Published Study reveals environmental impact of artificial sweeteners
(via sciencedaily.com) Original source A recently published study demonstrates how sucralose affects the behavior of cyanobacteria -- an aquatic photosynthetic bacteria -- and diatoms, microscopic algae that account for more than 30% of the primary food production in the marine food chain.
Published Ancient dingo DNA shows modern dingoes share little ancestry with modern dog breeds
(via sciencedaily.com) Original source A study of ancient dingo DNA revealed that the distribution of modern dingoes across Australia, including those on K'gari (formerly Fraser Island), pre-dates European colonization and interventions like the dingo-proof fence.
Published Coral reefs: Battlegrounds for survival in a changing climate
(via sciencedaily.com) Original source Coral reefs, those vibrant underwater cities, stand on the precipice of collapse. While rising ocean temperatures and coral bleaching grab headlines, a new essay reveals a hidden layer of complexity in this fight for survival: the often-overlooked roles of the reefs' smallest inhabitants.
Published New bio-based tool quickly detects concerning coronavirus variants
(via sciencedaily.com) Original source Researchers have developed a bioelectric device that can detect and classify new variants of coronavirus to identify those that are most harmful. It has the potential to do the same with other viruses, as well.
Published Genomic data integration improves prediction accuracy of apple fruit traits
(via sciencedaily.com) Original source Genotyping techniques can be used to select fruit trees with desired traits at the seedling stage, increasing the efficiency of fruit tree breeding. However, so far, there are multiple different genotyping systems, each generating distinct datasets. In a recent study, Japanese scientists revealed that integrating genomic data obtained with different genotyping systems can effectively combine with historical data, leveraging the accuracy of genomic predictions.
Published Visualizing short-lived intermediate compounds produced during chemical reactions
(via sciencedaily.com) Original source Immobilizing small synthetic molecules inside protein crystals proves to be a promising avenue for studying intermediate compounds formed during chemical reactions, scientists report. By integrating this method with time-resolved serial femtosecond crystallography, they successfully visualized reaction dynamics and rapid structural changes occurring within reaction centers immobilized inside protein crystals. This innovative strategy holds significant potential for the intelligent design of drugs, catalysts, and functional materials.
Published GeneMAP discovery platform will help define functions for 'orphan' metabolic proteins
(via sciencedaily.com) Original source Researchers have developed a discovery platform to probe the function of genes involved in metabolism -- the sum of all life-sustaining chemical reactions. The investigators used the new platform, called GeneMAP (Gene-Metabolite Association Prediction), to identify a gene necessary for mitochondrial choline transport.
Published Not so selfish after all: Viruses use freeloading genes as weapons
(via sciencedaily.com) Original source Certain pieces of DNA have been labeled as 'selfish genetic elements' due to notions that they don't contribute to a host organism's survival. Instead, researchers have now discovered that these elements have been weaponized and play a crucial role by cutting off a competitor's ability to reproduce.
Published Never-before-seen view of gene transcription captured
(via sciencedaily.com) Original source New tech reveals findings that address long-standing theories about how bacteria begin the process of making RNA from DNA.
Published Do genes-in-pieces code for proteins that fold in pieces?
(via sciencedaily.com) Original source A new study offers new insights into the evolution of foldable proteins.