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Categories: Biology: Biotechnology, Ecology: Trees
Published Nanocarrier with escape reflex
(via sciencedaily.com) Original source Protein-based drugs must be transported into cells in a way that prevents their immediate degradation. A new approach is intended to ensure that they remain intact only in certain cells, such as cancer cells. A Japanese research team has introduced a nanocarrier that can 'escape' from endosomes before its cargo is destroyed there. This ability to escape is only triggered within the endosomes of certain tumor cells.
Published Double trouble at chromosome ends
(via sciencedaily.com) Original source New findings suggest the end-replication problem, an old standby of biology textbooks, is twice as intricate as once thought.
Published Change in gene code may explain how human ancestors lost tails
(via sciencedaily.com) Original source A genetic change in our ancient ancestors may partly explain why humans don't have tails like monkeys.
Published New disease testing component facilitates lower-cost diagnostics
(via sciencedaily.com) Original source Biomedical researchers have developed a new, less expensive way to detect nuclease digestion -- one of the critical steps in many nucleic acid sensing applications, such as those used to identify COVID-19 and other infectious diseases.
Published First DNA study of ancient Eastern Arabians reveals malaria adaptation
(via sciencedaily.com) Original source People living in ancient Eastern Arabia appear to have developed resistance to malaria following the appearance of agriculture in the region around five thousand years ago.
Published New discovery shows how cells defend themselves during stressful situations
(via sciencedaily.com) Original source A recent study has unveiled an exciting discovery about how our cells defend themselves during stressful situations. The research shows that a tiny modification in the genetic material, called ac4C, acts as a crucial defender, helping cells create protective storage units known as stress granules. These stress granules safeguard important genetic instructions when the cell is facing challenges. The new findings could help shed light on relevant molecular pathways that could be targeted in disease.
Published Microbial comics: RNA as a common language, presented in extracellular speech-bubbles
(via sciencedaily.com) Original source Decoding the conversations between microbes of hypersaline environments reveals deep insights into the origins of complex life.
Published Human stem cells coaxed to mimic the very early central nervous system
(via sciencedaily.com) Original source The first stem cell culture method that produces a full model of the early stages of the human central nervous system has been developed by a team of engineers and biologists.
Published Cutting-edge 'protein lawnmower' created
(via sciencedaily.com) Original source Scientists have designed the first synthetic protein-based motor which harnesses biological reactions to fuel and propel itself. 'Imagine if a Roomba could be powered only by the dirt it picks up,' says one of the authors of the study. The motor uses the digestive enzyme trypsin to cut the peptides and convert them into the energy it needs to propel itself.
Published Blindness from some inherited eye diseases may be caused by gut bacteria
(via sciencedaily.com) Original source Sight loss in certain inherited eye diseases may be caused by gut bacteria, and is potentially treatable by antimicrobials, finds a new study in mice.
Published The small intestine adapt its size according to nutrient intake
(via sciencedaily.com) Original source Resizing of the intestine is a highly conserved strategy employed by a wide range of organisms to cope with fluctuation in nutrient availability. Nevertheless, very little is known about the mechanisms and signals underlying nutrient-mediated gut resizing. New research has identified one of the signaling pathways implicated in this process.
Published Biomolecular condensates -- regulatory hubs for plant iron supply
(via sciencedaily.com) Original source Iron is a micronutrient for plants. Biologists now show that regulatory proteins for iron uptake behave particularly dynamically in the cell nucleus when the cells are exposed to blue light -- an important signal for plant growth. They found that the initially homogeneously distributed proteins relocated together into 'biomolecular condensates' in the cell nucleus shortly after this exposure.
Published Ribosomes: Molecular wedge assists recycling
(via sciencedaily.com) Original source Researchers reveal how cells regenerate protein factories at endoplasmic reticulum.
Published Compound vital for all life likely played a role in life's origin
(via sciencedaily.com) Original source A chemical compound essential to all living things has been synthesized in a lab in conditions that could have occurred on early Earth, suggesting it played a role at the outset of life.
Published Copies of antibiotic resistance genes greatly elevated in humans and livestock
(via sciencedaily.com) Original source Researchers have uncovered a key link between the spread of antibiotic resistance genes and the evolution of resistance to new drugs in certain pathogens. Bacteria exposed to higher levels of antibiotics often harbor multiple identical copies of protective antibiotic resistance genes which are linked to 'jumping genes' that can move from strain to strain. Duplicate genes provide a mechanism for resistance to spread and enable evolving resistance to new drugs.
Published Damage to cell membranes causes cell aging
(via sciencedaily.com) Original source Researchers have discovered that damage to the cell membrane promotes cellular senescence, or cell aging.
Published Modeling tree masting
(via sciencedaily.com) Original source The effects of a phenomenon called tree masting on ecosystems and food webs can be better understood thanks to new theoretical models validated by real world observations.
Published Scientists discover link between leaky gut and accelerated biological aging
(via sciencedaily.com) Original source A professor has demonstrated a connection between viral damage to the gut and premature biological aging.
Published An awkward family reunion: Sea monsters are our cousins
(via sciencedaily.com) Original source The sea lamprey, a 500-million-year-old animal with a sharp-toothed suction cup for a mouth, is the thing of nightmares. A new study discovered that the hindbrain -- the part of the brain controlling vital functions like blood pressure and heart rate -- of both sea lampreys and humans is built using an extraordinarily similar molecular and genetic toolkit.
Published Compounds in female ginseng could lead to new osteoporosis treatments
(via sciencedaily.com) Original source With ever-increasing life expectancy comes the challenge of treating age-related disorders such as osteoporosis. Although there are effective drugs for treating this metabolic bone disease, they can be expensive and have side effects, limiting their availability to some people. In the search for alternative drug candidates, researchers have discovered and fully replicated a compound from a botanical source, female ginseng, that had potent anti-osteoporotic activity in cellular tests.