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Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Molecular Chemistry: Biochemistry Chemistry: Organic Chemistry Engineering: Nanotechnology
Published

Nanocarrier with escape reflex      (via sciencedaily.com)     Original source 

Protein-based drugs must be transported into cells in a way that prevents their immediate degradation. A new approach is intended to ensure that they remain intact only in certain cells, such as cancer cells. A Japanese research team has introduced a nanocarrier that can 'escape' from endosomes before its cargo is destroyed there. This ability to escape is only triggered within the endosomes of certain tumor cells.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Chemistry: Biochemistry Chemistry: General Chemistry: Organic Chemistry Engineering: Nanotechnology Physics: General Physics: Quantum Computing Physics: Quantum Physics
Published

New disease testing component facilitates lower-cost diagnostics      (via sciencedaily.com)     Original source 

Biomedical researchers have developed a new, less expensive way to detect nuclease digestion -- one of the critical steps in many nucleic acid sensing applications, such as those used to identify COVID-19 and other infectious diseases.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Geoscience: Environmental Issues
Published

First DNA study of ancient Eastern Arabians reveals malaria adaptation      (via sciencedaily.com)     Original source 

People living in ancient Eastern Arabia appear to have developed resistance to malaria following the appearance of agriculture in the region around five thousand years ago.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

New discovery shows how cells defend themselves during stressful situations      (via sciencedaily.com)     Original source 

A recent study has unveiled an exciting discovery about how our cells defend themselves during stressful situations. The research shows that a tiny modification in the genetic material, called ac4C, acts as a crucial defender, helping cells create protective storage units known as stress granules. These stress granules safeguard important genetic instructions when the cell is facing challenges. The new findings could help shed light on relevant molecular pathways that could be targeted in disease.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Molecular
Published

Human stem cells coaxed to mimic the very early central nervous system      (via sciencedaily.com)     Original source 

The first stem cell culture method that produces a full model of the early stages of the human central nervous system has been developed by a team of engineers and biologists.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Chemistry: Biochemistry Chemistry: Organic Chemistry
Published

Cutting-edge 'protein lawnmower' created      (via sciencedaily.com)     Original source 

Scientists have designed the first synthetic protein-based motor which harnesses biological reactions to fuel and propel itself. 'Imagine if a Roomba could be powered only by the dirt it picks up,' says one of the authors of the study. The motor uses the digestive enzyme trypsin to cut the peptides and convert them into the energy it needs to propel itself.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology
Published

Blindness from some inherited eye diseases may be caused by gut bacteria      (via sciencedaily.com)     Original source 

Sight loss in certain inherited eye diseases may be caused by gut bacteria, and is potentially treatable by antimicrobials, finds a new study in mice.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Molecular
Published

The small intestine adapt its size according to nutrient intake      (via sciencedaily.com)     Original source 

Resizing of the intestine is a highly conserved strategy employed by a wide range of organisms to cope with fluctuation in nutrient availability. Nevertheless, very little is known about the mechanisms and signals underlying nutrient-mediated gut resizing. New research has identified one of the signaling pathways implicated in this process.

Biology: Biotechnology Biology: Botany Biology: Cell Biology Biology: Genetics Biology: Molecular Ecology: Endangered Species
Published

Biomolecular condensates -- regulatory hubs for plant iron supply      (via sciencedaily.com)     Original source 

Iron is a micronutrient for plants. Biologists now show that regulatory proteins for iron uptake behave particularly dynamically in the cell nucleus when the cells are exposed to blue light -- an important signal for plant growth. They found that the initially homogeneously distributed proteins relocated together into 'biomolecular condensates' in the cell nucleus shortly after this exposure.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Compound vital for all life likely played a role in life's origin      (via sciencedaily.com)     Original source 

A chemical compound essential to all living things has been synthesized in a lab in conditions that could have occurred on early Earth, suggesting it played a role at the outset of life.

Biology: Biochemistry Biology: Biotechnology Biology: Evolutionary Biology: General Biology: Microbiology
Published

Copies of antibiotic resistance genes greatly elevated in humans and livestock      (via sciencedaily.com)     Original source 

Researchers have uncovered a key link between the spread of antibiotic resistance genes and the evolution of resistance to new drugs in certain pathogens. Bacteria exposed to higher levels of antibiotics often harbor multiple identical copies of protective antibiotic resistance genes which are linked to 'jumping genes' that can move from strain to strain. Duplicate genes provide a mechanism for resistance to spread and enable evolving resistance to new drugs.

Biology: Botany Biology: Zoology Ecology: Animals Ecology: Invasive Species Ecology: Nature Ecology: Trees Environmental: Ecosystems
Published

Modeling tree masting      (via sciencedaily.com)     Original source 

The effects of a phenomenon called tree masting on ecosystems and food webs can be better understood thanks to new theoretical models validated by real world observations.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Evolutionary Biology: General Biology: Genetics Biology: Marine Ecology: Sea Life Offbeat: General Offbeat: Paleontology and Archeology Offbeat: Plants and Animals
Published

An awkward family reunion: Sea monsters are our cousins      (via sciencedaily.com)     Original source 

The sea lamprey, a 500-million-year-old animal with a sharp-toothed suction cup for a mouth, is the thing of nightmares. A new study discovered that the hindbrain -- the part of the brain controlling vital functions like blood pressure and heart rate -- of both sea lampreys and humans is built using an extraordinarily similar molecular and genetic toolkit.

Biology: Biochemistry Biology: Biotechnology Biology: General
Published

Compounds in female ginseng could lead to new osteoporosis treatments      (via sciencedaily.com)     Original source 

With ever-increasing life expectancy comes the challenge of treating age-related disorders such as osteoporosis. Although there are effective drugs for treating this metabolic bone disease, they can be expensive and have side effects, limiting their availability to some people. In the search for alternative drug candidates, researchers have discovered and fully replicated a compound from a botanical source, female ginseng, that had potent anti-osteoporotic activity in cellular tests.