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Categories: Biology: Biotechnology, Ecology: Trees
Published New system triggers cellular waste disposal
(via sciencedaily.com) Original source Established treatments for cancer and other diseases often focus on inhibiting harmful enzymes to mitigate their effects. However, a more innovative approach has emerged: harnessing the cell's natural waste disposal system not just to deactivate but to entirely eradicate these proteins. Researchers have previously demonstrated the efficacy of this approach through two distinct methods. Now they unveil a third system capable of targeting and disposing of previously inaccessible proteins.
Published Detecting pathogens faster and more accurately by melting DNA
(via sciencedaily.com) Original source A new analysis method can detect pathogens in blood samples faster and more accurately than blood cultures, which are the current state of the art for infection diagnosis. The new method, called digital DNA melting analysis, can produce results in under six hours, whereas culture typically requires 15 hours to several days, depending on the pathogen.
Published Breakthrough in developing the PD-1-enhanced DNA vaccine for over 6-year cART-free AIDS prevention and virologic control
(via sciencedaily.com) Original source Researchers found that PD-1-enhanced DNA vaccination can induce sustained virus-specific CD8+ T cell immunity in an AIDS monkey model. The vaccinated monkeys remained free of AIDS for six years and achieved virologic control without the need for combination antiretroviral therapy (cART), a treatment used to suppress viral replication in individuals living with human immunodeficiency virus (HIV). The study also found that polyfunctional and broadly reactive effector-memory virus-specific T cells were maintained in the protected experimental macaques for over six years. The findings provide supporting evidence that the PD-1-enhanced DNA vaccine strategy holds promise as a third-generation DNA vaccine for AIDS prevention and immunotherapy.
Published Researchers are using RNA in a new approach to fight HIV
(via sciencedaily.com) Original source A pharmacy associate professor has developed a novel nanomedicine loaded with genetic material called small interfering RNAs (siRNA) to fight human immunodeficiency virus (HIV) using gene therapy.
Published New model identifies drugs that shouldn't be taken together
(via sciencedaily.com) Original source Researchers have developed a multipronged strategy to identify the transporters used by different drugs. Their approach, which makes use of both tissue models and machine-learning algorithms, has already revealed that a commonly prescribed antibiotic and a blood-thinner can interfere with each other.
Published Scientists develop novel radiotracer for earlier detection of disease
(via sciencedaily.com) Original source Scientists have developed a new radiotracer (called [18F]4-FDF) that can map how cells use fructose for energy.
Published Genetic insights and conservation challenges of Nara's sacred deer
(via sciencedaily.com) Original source In Nara, Japan, the revered sika deer faces a dilemma as their escalating population damages local farmlands. A new study has revealed a complex situation: while the sanctuary's deer upholds a distinct genetic identity, the surrounding areas display a blend of genetic lineages. This exposes a pressing predicament: whether to cull the 'pest' deer around sanctuary or risk losing a sacred genetic legacy.
Published Eating too much protein is bad for your arteries, and this amino acid is to blame
(via sciencedaily.com) Original source Consuming over 22% of dietary calories from protein can lead to increased activation of immune cells that play a role in atherosclerotic plaque formation and drive the disease risk, new study showed.
Published Toxoplasmosis: Evolution of infection machinery
(via sciencedaily.com) Original source Researchers have identified a protein that evolved concurrently with the emergence of cellular compartments crucial for the multiplication of the toxoplasmosis pathogen.
Published Superbug killer: New synthetic molecule highly effective against drug-resistant bacteria
(via sciencedaily.com) Original source A new antibiotic overcomes antimicrobial resistance mechanisms that have rendered many modern drugs ineffective and are driving a global public health crisis.
Published Reforestation programs could threaten vast area of tropical grasslands
(via sciencedaily.com) Original source New research reveals the scale of inappropriate reforestation projects across Africa. A new study reveals that an area the size of France is threatened by forest restoration initiatives, such as the AFR100 initiative (African Forest Landscape Restoration Initiative), due to inappropriate restoration in the form of tree-planting.
Published Asexual propagation of crop plants gets closer
(via sciencedaily.com) Original source When the female gametes in plants become fertilized, a signal from the sperm activates cell division, leading to the formation of new plant seeds. This activation can also be deliberately triggered without fertilization, as researchers have shown. Their findings open up new avenues for the asexual propagation of crop plants.
Published Ancient retroviruses played a key role in the evolution of vertebrate brains
(via sciencedaily.com) Original source Researchers report that ancient viruses may be to thank for myelin -- and, by extension, our large, complex brains. The team found that a retrovirus-derived genetic element or 'retrotransposon' is essential for myelin production in mammals, amphibians, and fish. The gene sequence, which they dubbed 'RetroMyelin,' is likely a result of ancient viral infection, and comparisons of RetroMyelin in mammals, amphibians, and fish suggest that retroviral infection and genome-invasion events occurred separately in each of these groups.
Published Scientists are unravelling the secrets of red and grey squirrel competition
(via sciencedaily.com) Original source Researchers have identified significant differences between the diversity of gut bacteria in grey squirrels compared to red squirrels which could hold the key to further understanding the ability of grey squirrels to outcompete red squirrels in the UK.
Published Team creates novel rabies viral vectors for neural circuit mapping
(via sciencedaily.com) Original source A research team has created 20 new recombinant rabies viral vectors for neural circuit mapping that offer a range of significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer's disease brain neurons.
Published Key genes linked to DNA damage and human disease uncovered
(via sciencedaily.com) Original source Scientists unveil 145 genes vital for genome health, and possible strategies to curb progression of human genomic disorders.
Published Researchers uncover mechanisms behind enigmatic shapes of nuclei
(via sciencedaily.com) Original source White blood cells known as neutrophils feature a nucleus that is structured strikingly different than most nuclei. These unique shapes permit neutrophils to travel all over the body to combat invading pathogens. Scientists have now deciphered the shapeshifting puzzle of the neutrophil nucleus.
Published Microscopy: Overcoming the traditional resolution limit for the fast co-tracking of molecules
(via sciencedaily.com) Original source Researchers have developed an innovative method to simultaneously track rapid dynamic processes of multiple molecules at the molecular scale.
Published Pesticides to help protect seeds can adversely affect earthworms' health
(via sciencedaily.com) Original source While pesticides protect crops from hungry animals, pesky insects, or even microbial infections, they also impact other vital organisms, including bees and earthworms. And today, research reveals that worms are affected by the relatively small amounts of chemicals that can leach out of pesticide-treated seeds. Exposure to nonlethal amounts of these insecticides and fungicides resulted in poor weight gain and mitochondrial DNA (mtDNA) damage in the worms.
Published Female lab mice behave very differently when placed outdoors
(via sciencedaily.com) Original source A new study has examined social behavior of lab mice in large outdoor enclosures.