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Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

DNA construction led to unexpected discovery of important cell function      (via sciencedaily.com)     Original source 

Researchers have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new avenues for understanding how the Notch signalling pathway works and how it is involved in several serious diseases.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Microbiology Offbeat: General Offbeat: Plants and Animals
Published

Ancient 'chewing gum' reveals stone age diet      (via sciencedaily.com)     Original source 

What did people eat on the west coast of Scandinavia 10,000 years ago? A new study of the DNA in a chewing gum shows that deer, trout and hazelnuts were on the diet. It also shows that one of the individuals had severe problems with her teeth.

Biology: Biochemistry Biology: Biotechnology Biology: Botany Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Ecology: Endangered Species
Published

Nearly dead plants brought back to life: Keys to aging hidden in the leaves      (via sciencedaily.com)     Original source 

Scientists have known about a particular organelle in plant cells for over a century. However, scientists have only now discovered that organelle's key role in aging.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Study throws our understanding of gene regulation for a loop      (via sciencedaily.com)     Original source 

To function properly, the genetic material is highly organized into loop structures that often bring together widely separated sections of the genome critical to the regulation of gene activity. Scientists now address how these loops can help repress or silence gene activity, with potentially far-reaching effects on human health.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Machine learning reveals sources of heterogeneity among cells in our bodies      (via sciencedaily.com)     Original source 

A team of scientists discovered the secrets of cell variability in our bodies. The findings of this research are expected to have far-reaching effects, such as improvement in the efficacy of chemotherapy treatments, or set a new paradigm in the study of antibiotic-resistant bacteria.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Chemistry: Biochemistry Chemistry: Organic Chemistry Physics: Optics
Published

Glowing COVID-19 diagnostic test prototype produces results in one minute      (via sciencedaily.com)     Original source 

Cold, flu and COVID-19 season brings that now-familiar ritual: swab, wait, look at the result. But what if, instead of taking 15 minutes or more, a test could quickly determine whether you have COVID-19 with a glowing chemical? In a new study, researchers describe a potential COVID-19 test inspired by bioluminescence. Using a molecule found in crustaceans, they have developed a rapid approach that detects SARS-CoV-2 protein comparably to one used in vaccine research.

Biology: Botany Ecology: General Ecology: Nature Ecology: Research Ecology: Trees Environmental: Ecosystems Environmental: General Geoscience: Environmental Issues
Published

Climate change threatens global forest carbon sequestration, study finds      (via sciencedaily.com)     Original source 

Climate change is causing Western U.S. forests to be less effective carbon sinks, even as it boosts the productivity of forests in the Eastern U.S., according to new research.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Microbiology Biology: Molecular Chemistry: Biochemistry
Published

Unraveling the role of supersulfides in regulating mitochondrial function and longevity      (via sciencedaily.com)     Original source 

Supersulfides, many of which are produced by cysteinyl-tRNA synthetase (CARS), are essential compounds across many different lifeforms. However, the precise physiological roles of CARS-produced supersulfide are unclear. Now, using a strategically engineered yeast mutant with a deficient CARS gene, researchers from Japan have shown that supersulfides control cell longevity by mediating mitochondrial energy metabolism and regulating protein quality.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Bioinformatics: Researchers develop a new machine learning approach      (via sciencedaily.com)     Original source 

To combat viruses, bacteria and other pathogens, synthetic biology offers new technological approaches whose performance is being validated in experiments. Researchers applied data integration and artificial intelligence (AI) to develop a machine learning approach that can predict the efficacy of CRISPR technologies more accurately than before.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Molecular
Published

A novel pathway regulating lipid biosynthesis by fatty acids      (via sciencedaily.com)     Original source 

Sterol regulatory element-binding proteins (SREBPs) play a crucial role in lipid biosynthesis. In a recent study, researchers identified a novel cleavage enzyme of SREBP-1c, a key player in fatty acid biosynthesis. Moreover, the team unveiled, for the first time, that the biosynthesis process of fatty acid in the liver is activated by saturated fatty acids and inhibited by polyunsaturated fatty acids, providing new insights into the intricate workings of this cleavage system.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Molecular Chemistry: Biochemistry
Published

3D in vitro human atherosclerosis model for high-throughput drug screening      (via sciencedaily.com)     Original source 

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, researchers report.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: Evolutionary Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Offbeat: General Offbeat: Plants and Animals
Published

Researchers create light-powered yeast, providing insights into evolution, biofuels, cellular aging      (via sciencedaily.com)     Original source 

Researchers have engineered one of the world's first yeast cells able to harness energy from light, expanding our understanding of the evolution of this trait -- and paving the way for advancements in biofuel production and cellular aging.

Biology: Biochemistry Biology: Biotechnology Biology: Botany Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Ecology: Endangered Species
Published

New rice lines for Africa offer virus protection      (via sciencedaily.com)     Original source 

The so-called Rice Yellow Mottle Virus (for short: RYMV) is responsible for high crop losses in Africa, particularly among small-scale farmers. A research team has now produced rice lines that are resistant to the disease by means of genome editing. The rice varieties are a preliminary step toward being able to generate resistant locally adapted elite varieties for small-scale food producers in Africa.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Molecular Chemistry: Biochemistry Chemistry: General Chemistry: Organic Chemistry Chemistry: Thermodynamics
Published

Spying on a shape-shifting protein      (via sciencedaily.com)     Original source 

Researchers are using crystallography to gain a better understanding of how proteins shapeshift. The knowledge can provide valuable insight into stopping and treating diseases.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Protein complex discovered to control DNA repair      (via sciencedaily.com)     Original source 

The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched. A scientific team has now discovered a previously unrecognized control point for these processes. This could lead to a new approach for the development of cancer therapies aimed at inhibiting the repair of damaged cancer cells.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Genetics Biology: Microbiology Biology: Molecular
Published

A new type of plant metalloreductase maintains root growth under low phosphorus      (via sciencedaily.com)     Original source 

Phosphorus is essential for undisturbed plant growth and development. However, in many soils, phosphorus is only poorly available. One mechanism used by plants to increase phosphorus availability is the release of malate, an organic acid, which can form complexes with iron or aluminium in the soil, thereby liberating sorbed phosphate. However, this response can also result in iron overaccumulation, which can inhibit root growth.

Biology: Biochemistry Biology: Botany Biology: General Ecology: Extinction Ecology: General Ecology: Invasive Species Ecology: Nature Ecology: Research Ecology: Trees Environmental: Biodiversity Environmental: Ecosystems Environmental: General Geoscience: Earth Science Geoscience: Geography
Published

Scientists name the most common tropical tree species      (via sciencedaily.com)     Original source 

Researchers have found almost identical patterns of tree diversity across the world's tropical forests. The study of over one million trees across 1,568 locations found that just 2.2% of tree species make up 50% of the total number of trees in tropical forests across Africa, the Amazon, and Southeast Asia. Each continent consists of the same proportion of a few common species and many rare species.

Biology: Biochemistry Biology: Biotechnology Biology: Evolutionary Biology: General Biology: Microbiology Ecology: Animals Offbeat: General Offbeat: Paleontology and Archeology Offbeat: Plants and Animals Paleontology: General
Published

Largest diversity study of 'magic mushrooms' investigates the evolution of psychoactive psilocybin production      (via sciencedaily.com)     Original source 

The genomic analysis of 52 Psilocybe specimens includes 39 species that have never been sequenced. Psilocybe arose much earlier than previously thought -- about 65 million years ago -- and the authors found that psilocybin was first synthesized in mushrooms in the genus Psilocybe. Their analysis revealed two distinct gene orders within the gene cluster that produces psilocybin. The two gene patterns correspond to an ancient split in the genus, suggesting two independent acquisitions of psilocybin in its evolutionary history. The study is the first to reveal such a strong evolutionary pattern within the gene sequences underpinning the psychoactive proteins synthesis.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Smart skin bacteria are able to secrete and produce molecules to treat acne      (via sciencedaily.com)     Original source 

An experimental study has shown that a type of skin bacterium can efficiently be engineered to produce a protein to regulate sebum production. This application could treat acne without compromising the homeostasis of the entire skin microbiome.