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Categories: Biology: Biotechnology, Space: Cosmology
Published Researchers discover key gene for toxic alkaloid in barley
(via sciencedaily.com) Original source Barley is one of the most important cereal crops on a global scale. Many barley cultivars produce a toxic alkaloid called gramine that affects the suitability of barley as fodder, but also helps to protect barley from pathogens. So far, the potential of manipulating gramine levels has not been harnessed for plant breeding, because the genetic basis of gramine production has been unresolved. Research groups now disclose the complete biosynthetic pathway of gramine and demonstrate how gramine biosynthesis can be introduced into model organisms or removed from barley.
Published Connecting the dots to shape growth forces
(via sciencedaily.com) Original source Branching patterns are prevalent in our natural environment and the human body, such as in the lungs and kidneys. For example, specific genes that express growth factor proteins are known to influence the development of the lungs' complex branches. Researchers have unveiled a regulatory system linking signal, force, and shape in mouse lung structure development. The team recognized that the signal protein ERK plays an active role in causing growing lung tissue to curve.
Published Synaptic protein change during development offers clues on evolution and disease
(via sciencedaily.com) Original source An analysis of how synaptic proteins change during early development reveals differences between mice and marmosets but also what's different in individuals with autism spectrum disorders. The findings offer first insights into the mechanism behind synaptic development and open up routes for research on possible treatments.
Published A combination of approved drugs enhances the delivery of anti-bacterial medications to treat tuberculosis
(via sciencedaily.com) Original source Researchers have found that approved drugs that were originally shown to normalize blood vessels surrounding tumors (to improve drug delivery to cancer cells) can enhance the delivery of anti-microbial medications to kill tuberculosis bacteria residing in the lungs.
Published Sweet success: Sugarcane's complex genetic code cracked
(via sciencedaily.com) Original source Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants. Exploring sugarcane's genetic code could help researchers develop more resilient and productive crops, with implications for both sugar production and biofuels.
Published Scientists extract genetic secrets from 4,000-year-old teeth to illuminate the impact of changing human diets over the centuries
(via sciencedaily.com) Original source Researchers have recovered remarkably preserved microbiomes from two teeth dating back 4,000 years, found in an Irish limestone cave. Genetic analyses of these microbiomes reveal major changes in the oral microenvironment from the Bronze Age to today. The teeth both belonged to the same male individual and also provided a snapshot of his oral health.
Published New technique for predicting protein dynamics may prove big breakthrough for drug discovery
(via sciencedaily.com) Original source Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them. To that end, a team of researchers has developed a way of using machine learning to rapidly predict multiple protein configurations to advance understanding of protein dynamics and functions.
Published New enzymatic cocktail can kill tuberculosis-causing mycobacteria
(via sciencedaily.com) Original source An enzymatic cocktail can kill a variety of mycobacterial species of bacteria, including those that cause tuberculosis.
Published Old immune systems revitalized in mouse study, improving vaccine response
(via sciencedaily.com) Original source Those with aging immune systems struggle to fight off novel viruses and respond weakly to vaccination. Researchers were able to revitalize the immune system in mice.
Published Researchers show that introduced tardigrade proteins can slow metabolism in human cells
(via sciencedaily.com) Original source Tardigrade proteins are potential candidates in technologies centered on slowing the aging process and in long-term storage of human cells.
Published Severe hurricanes boost influx of juveniles and gene flow in a coral reef sponge
(via sciencedaily.com) Original source A study is the first to evaluate substrate recolonization by sponges in the U.S. Virgin Islands after two catastrophic storms using genetic analyses to understand how much clonality verses sexual recruitment occurs on coral reefs post-storms. Results show that populations of clonal marine species with low pelagic dispersion, such as A. cauliformis, may benefit from increased frequency and magnitude of hurricanes to maintain genetic diversity and combat inbreeding, enhancing the resilience of Caribbean sponge communities to extreme storm events.
Published Discovery of amino acid unveils how light makes plants open
(via sciencedaily.com) Original source Scientists have uncovered a unique mechanism that regulates the opening of stomata in plants. Phosphorylation of the amino acid Thr881 on the plasma membrane proton pump plays a key role in this process. The study paves the way for the targeted manipulation of plant physiology, with potential applications in agriculture and environmental sustainability.
Published Novel electrochemical sensor detects dangerous bacteria
(via sciencedaily.com) Original source Researchers have developed a novel sensor for the detection of bacteria. It is based on a chip with an innovative surface coating. This ensures that only very specific microorganisms adhere to the sensor -- such as certain pathogens. The larger the number of organisms, the stronger the electric signal generated by the chip. In this way, the sensor is able not only to detect dangerous bacteria with a high level of sensitivity but also to determine their concentration.
Published Natural recycling at the origin of life
(via sciencedaily.com) Original source How was complex life able to develop on the inhospitable early Earth? At the beginning there must have been ribonucleic acid (RNA) to carry the first genetic information. To build up complexity in their sequences, these biomolecules need to release water. On the early Earth, which was largely covered in seawater, that was not so easy to do.
Published As we age, our cells are less likely to express longer genes
(via sciencedaily.com) Original source Aging may be less about specific 'aging genes' and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers. A decline in the expression of long genes with age has been observed in a wide range of animals, from worms to humans, in various human cell and tissue types, and also in individuals with neurodegenerative disease. Mouse experiments show that the phenomenon can be mitigated via known anti-aging factors, including dietary restriction.
Published Maize genes control little helpers in the soil
(via sciencedaily.com) Original source Tiny organisms such as bacteria and fungi help to promote the health and function of plant roots. It is commonly assumed that the composition of these microbes is dependent on the properties of the soil. However, researchers have now discovered when studying different local varieties of maize that the genetic makeup of the plants also helps to influence which microorganisms cluster around the roots.
Published Decoding the plant world's complex biochemical communication networks
(via sciencedaily.com) Original source A research team has begun translating the complex molecular language of petunias. Their grammar and vocabulary are well hidden, however, within the countless proteins and other compounds that fill floral cells. Being rooted to the ground, plants can't run away from insects, pathogens or other threats to their survival. But plant scientists have long known that they do send warnings to each other via scent chemicals called volatile organic compounds.
Published Scientists find one of the most ancient stars that formed in another galaxy
(via sciencedaily.com) Original source The first generation of stars transformed the universe. Inside their cores, simple hydrogen and helium fused into a rainbow of elements. When these stars died, they exploded and sent these new elements across the universe. The iron running in your veins and the calcium in your teeth and the sodium powering your thoughts were all born in the heart of a long-dead star.
Published Craving snacks after a meal? It might be food-seeking neurons, not an overactive appetite
(via sciencedaily.com) Original source Psychologists have discovered a circuit in the brain of mice that makes them crave food and seek it out, even when they are not hungry. When stimulated, this cluster of cells propels mice to forage vigorously and to prefer fatty and pleasurable foods like chocolate over healthier foods like carrots.
Published Decoding the Easter Bunny -- an eastern Finnish brown hare to represent the standard for the species' genome
(via sciencedaily.com) Original source Biologists have published a chromosomally assembled reference genome for the European brown hare. The genome consists of 2.9 billion base pairs, which form 23 autosomal chromosomes, and X and Y sex chromosomes. The timing of the genome release is very appropriate as the brown hare also represents the original Easter Bunny familiar from European folklore.