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Categories: Biology: Biotechnology, Environmental: Biodiversity
Published Editing without 'cutting': Molecular mechanisms of new gene-editing tool revealed
(via sciencedaily.com) Original source New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.' Functional analysis based on these structures also revealed how a 'prime editor' could achieve reverse transcription, synthesizing DNA from RNA, without 'cutting' both strands of the double helix. Clarifying these molecular mechanisms contributes greatly to designing gene-editing tools accurate enough for gene therapy treatments.
Published Chicken feathers to deliver chemotherapy drugs and repair enzymes
(via sciencedaily.com) Original source A new method of drug delivery using proline, an amino acid found in chicken feathers and skin tissue, could be used to limit the side effects of chemotherapy and repair important enzymes, new research suggests.
Published New antibiotic kills pathogenic bacteria, spares healthy gut microbes
(via sciencedaily.com) Original source Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse gut. The drug, called lolamicin, also warded off secondary infections with Clostridioides difficile, a common and dangerous hospital-associated bacterial infection, and was effective against more than 130 multidrug-resistant bacterial strains in cell culture.
Published What makes some plant groups so successful?
(via sciencedaily.com) Original source Researchers involved in cataloguing the world's plant species are hunting for answers as to what makes some groups of plants so successful. One of their major goals is to predict more accurately which lineages of flowering plants -- some of which are of huge importance to people and to ecosystems -- are at a greater risk from global climate change.
Published Fatal attraction: When endangered species try to mate with domestic relatives, both wildlife and people lose
(via sciencedaily.com) Original source Sticks and stones aren't enough to thwart biological attraction, but sometimes those are the only tools available to pastoralists trying to prevent wildlife from eloping with their livestock. A new study brings awareness to both the human impacts of these encounters -- ranging from economic loss to death -- and conservation concerns for the wild animals that are often endangered.
Published Heart healthy behaviors may help reverse rapid cell aging
(via sciencedaily.com) Original source The benefits gained with higher lifestyle scores may be associated with the positive influence of heart disease risk factors on the aging of the body and its cells, finds a new study in the Journal of the American Heart Association
Published Some species may tolerate climate change better than expected
(via sciencedaily.com) Original source A new model reassesses the proportion of terrestrial and marine species threatened with extinction by climate change. While the forecasts of traditional models estimate that the diversity of terrestrial species in tropical areas could decrease by 54% between now and 2041-2060, this model is more moderate, predicting a decrease of 39%. Nevertheless, this proportion remains alarming and confirms the importance of taking urgent measures to mitigate climate change and its impact on biodiversity.
Published Slugs and snails love the city, unlike other animals
(via sciencedaily.com) Original source Most native species avoid more urbanized areas of Los Angeles, but slugs and snails may actually prefer these environments, according to a new study.
Published Wild megalopolis: Study shows unexpected pockets of biodiversity pepper Los Angeles
(via sciencedaily.com) Original source Researchers, in partnership with the city of Los Angeles, have developed the urban association index to help identify how well or poorly individual wildlife species are doing in the city. The researchers found unexpected pockets of biodiversity deep in the city, but they say it will still be a challenge to elevate Los Angeles' overall level of biodiversity.
Published Marine Protected Areas don't line up with core habitats of rare migratory fish, finds new research
(via sciencedaily.com) Original source 62% of Marine Protected Areas (MPAs) designated to protect rare migratory fish species are outside of their core habitats, according to a new modeling study.
Published Smarter foragers do not forage smarter
(via sciencedaily.com) Original source Why do primates have big brains? In the Panamanian rainforest, scientists pitted large-brained primates against smaller-brained mammals to find out who was the smartest forager.
Published Bringing back an ancient bird
(via sciencedaily.com) Original source Using ancient DNA extracted from the toe bone of a museum specimen, biologists have sequenced the genome of an extinct, flightless bird called the little bush moa, shedding light into an unknown corner of avian genetic history. The work is the first complete genetic map of the turkey-sized bird whose distant living cousins include the ostrich, emu, and kiwi.
Published Mechanisms for selective multiple sclerosis treatment strategy
(via sciencedaily.com) Original source Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.
Published 'Cloaked' proteins deliver cancer-killing therapeutics into cells
(via sciencedaily.com) Original source Scientists have designed a way to 'cloak' proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.
Published Genetic mosaicism more common than thought
(via sciencedaily.com) Original source Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of genomes in single cells that are too difficult to detect with other methods.
Published Global activity of seafloor biodiversity mapped
(via sciencedaily.com) Original source A team of scientists has used artificial intelligence (AI) to map the activities of seafloor invertebrate animals, such as worms, clams and shrimps, across all the oceans of the world.
Published New approach to Epstein-Barr virus and resulting diseases
(via sciencedaily.com) Original source The Epstein-Barr virus can cause a spectrum of diseases, including a range of cancers. Emerging data now show that inhibition of a specific metabolic pathway in infected cells can diminish latent infection and therefore the risk of downstream disease.
Published New 'atlas' provides unprecedented insights on how genes function in early embryo development
(via sciencedaily.com) Original source Biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new 'gene atlas' with 4-D imaging, the researchers captured unprecedented insights on how embryonic development unfolds.
Published Novel approach to interrogate tissue-specific protein-protein interactions
(via sciencedaily.com) Original source Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery. However, our current understanding of such protein-protein interactions often lacks cellular contexts because they were usually studied in an in vitro system or in cells isolated from their tissue environment. Effective methods to investigate protein-protein interactions in a tissue-specific manner are largely missing.
Published Tracking down the genetic causes of lupus to personalize treatment
(via sciencedaily.com) Original source Treatment of autoimmune diseases like lupus has long relied on steroids to knock down the immune system, but more targeted therapies are currently undergoing clinical trials. To make sure these therapies get to the patients who will benefit, work is needed to identify the specific mutations behind each patient's disease. Researchers now report several dozen mutations associated with oversensitive toll-like receptors -- a major cause of autoimmune disease -- and linked two mutations to patients.