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Categories: Biology: Biotechnology, Geoscience: Volcanoes

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Resizing of the intestine is a highly conserved strategy employed by a wide range of organisms to cope with fluctuation in nutrient availability. Nevertheless, very little is known about the mechanisms and signals underlying nutrient-mediated gut resizing. New research has identified one of the signaling pathways implicated in this process.

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Iron is a micronutrient for plants. Biologists now show that regulatory proteins for iron uptake behave particularly dynamically in the cell nucleus when the cells are exposed to blue light -- an important signal for plant growth. They found that the initially homogeneously distributed proteins relocated together into 'biomolecular condensates' in the cell nucleus shortly after this exposure.

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Researchers reveal how cells regenerate protein factories at endoplasmic reticulum.

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A chemical compound essential to all living things has been synthesized in a lab in conditions that could have occurred on early Earth, suggesting it played a role at the outset of life.

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Researchers have uncovered a key link between the spread of antibiotic resistance genes and the evolution of resistance to new drugs in certain pathogens. Bacteria exposed to higher levels of antibiotics often harbor multiple identical copies of protective antibiotic resistance genes which are linked to 'jumping genes' that can move from strain to strain. Duplicate genes provide a mechanism for resistance to spread and enable evolving resistance to new drugs.

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Researchers have discovered that damage to the cell membrane promotes cellular senescence, or cell aging.

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A detailed survey of the volcanic underwater deposits around the Kikai caldera in Japan clarified the deposition mechanisms as well as the event's magnitude. As a result, the research team found that the event 7,300 years ago was the largest volcanic eruption in the Holocene by far.

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A professor has demonstrated a connection between viral damage to the gut and premature biological aging.

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The sea lamprey, a 500-million-year-old animal with a sharp-toothed suction cup for a mouth, is the thing of nightmares. A new study discovered that the hindbrain -- the part of the brain controlling vital functions like blood pressure and heart rate -- of both sea lampreys and humans is built using an extraordinarily similar molecular and genetic toolkit.

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With ever-increasing life expectancy comes the challenge of treating age-related disorders such as osteoporosis. Although there are effective drugs for treating this metabolic bone disease, they can be expensive and have side effects, limiting their availability to some people. In the search for alternative drug candidates, researchers have discovered and fully replicated a compound from a botanical source, female ginseng, that had potent anti-osteoporotic activity in cellular tests.

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Established treatments for cancer and other diseases often focus on inhibiting harmful enzymes to mitigate their effects. However, a more innovative approach has emerged: harnessing the cell's natural waste disposal system not just to deactivate but to entirely eradicate these proteins. Researchers have previously demonstrated the efficacy of this approach through two distinct methods. Now they unveil a third system capable of targeting and disposing of previously inaccessible proteins.

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A new analysis method can detect pathogens in blood samples faster and more accurately than blood cultures, which are the current state of the art for infection diagnosis. The new method, called digital DNA melting analysis, can produce results in under six hours, whereas culture typically requires 15 hours to several days, depending on the pathogen.

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Researchers found that PD-1-enhanced DNA vaccination can induce sustained virus-specific CD8+ T cell immunity in an AIDS monkey model. The vaccinated monkeys remained free of AIDS for six years and achieved virologic control without the need for combination antiretroviral therapy (cART), a treatment used to suppress viral replication in individuals living with human immunodeficiency virus (HIV). The study also found that polyfunctional and broadly reactive effector-memory virus-specific T cells were maintained in the protected experimental macaques for over six years. The findings provide supporting evidence that the PD-1-enhanced DNA vaccine strategy holds promise as a third-generation DNA vaccine for AIDS prevention and immunotherapy.

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A pharmacy associate professor has developed a novel nanomedicine loaded with genetic material called small interfering RNAs (siRNA) to fight human immunodeficiency virus (HIV) using gene therapy.

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Researchers have developed a multipronged strategy to identify the transporters used by different drugs. Their approach, which makes use of both tissue models and machine-learning algorithms, has already revealed that a commonly prescribed antibiotic and a blood-thinner can interfere with each other.

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Scientists have developed a new radiotracer (called [18F]4-FDF) that can map how cells use fructose for energy.

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In Nara, Japan, the revered sika deer faces a dilemma as their escalating population damages local farmlands. A new study has revealed a complex situation: while the sanctuary's deer upholds a distinct genetic identity, the surrounding areas display a blend of genetic lineages. This exposes a pressing predicament: whether to cull the 'pest' deer around sanctuary or risk losing a sacred genetic legacy.

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Consuming over 22% of dietary calories from protein can lead to increased activation of immune cells that play a role in atherosclerotic plaque formation and drive the disease risk, new study showed.

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Researchers have identified a protein that evolved concurrently with the emergence of cellular compartments crucial for the multiplication of the toxoplasmosis pathogen.

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A new antibiotic overcomes antimicrobial resistance mechanisms that have rendered many modern drugs ineffective and are driving a global public health crisis.