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Categories: Biology: Biotechnology, Geoscience: Volcanoes
Published Yeast with an over half synthetic genome is created in the lab
(via sciencedaily.com) Original source Researchers have combined over seven synthetic chromosomes that were made in the lab into a single yeast cell, resulting in a strain with more than 50% synthetic DNA that survives and replicates similarly to wild yeast strains. A global consortium is working to develop the first synthetic eukaryote genome from scratch. The team has now synthesized and debugged all sixteen yeast chromosomes.
Published Scientists take major step towards completing the world's first synthetic yeast
(via sciencedaily.com) Original source A team of Scientists has completed construction of a synthetic chromosome as part of a major international project to build the world's first synthetic yeast genome. The work represents completion of one of the 16 chromosomes of the yeast genome, which is part of the biggest project ever in synthetic biology; the international synthetic yeast genome collaboration. The collaboration, known as 'Sc2.0' has been a 15-year project involving teams from around the world (UK, US, China, Singapore, UK, France and Australia), working together to make synthetic versions of all of yeast's chromosomes. Alongside this paper, another 9 publications are also released today from other teams describing their synthetic chromosomes. The final completion of the genome project -- the largest synthetic genome ever -- is expected next year.
Published Cracking the code: Genome sequencing reveals why songbirds are larger in colder climates
(via sciencedaily.com) Original source Scientists have unlocked the genetic basis underlying the remarkable variation in body size observed in song sparrows, one of North America's most familiar and beloved songbirds. This discovery also provides insights into this species' capacity to adapt to the challenges of climate change. The study used genomic sequencing to successfully pinpoint eight genetic variants, or DNA mutations, largely responsible for the nearly threefold difference in body size observed across the song sparrow range from Mexico to Alaska.
Published 'Biodiversity time machine' provides insights into a century of loss
(via sciencedaily.com) Original source AI analysis shows pollution levels, extreme weather events and increasing temperatures devastates biodiversity in freshwater lakes.
Published 450-million-year-old organism finds new life in Softbotics
(via sciencedaily.com) Original source Researchers have used fossil evidence to engineer a soft robotic replica of pleurocystitids, a marine organism that existed nearly 450 million years ago and is believed to be one of the first echinoderms capable of movement using a muscular stem.
Published Plants' ingenious defense against mutational damage
(via sciencedaily.com) Original source How do plants deal with mutations in their 'power stations'? By exploiting randomness to create diversity, say researchers.
Published Viral impostors: Breakthrough for virus research
(via sciencedaily.com) Original source The penetration of viruses into cells can now be tracked with unprecedented accuracy thanks to an innovative design for pseudoviruses.
Published New secrets about cat evolution revealed
(via sciencedaily.com) Original source By comparing genomes of several cat species, the project has helped researchers understand why cat genomes tend to have fewer complex genetic variations (such as rearrangements of DNA segments) than other mammal groups, like primates. It also revealed new insights into which parts of cat DNA are most likely to evolve rapidly and how they play a role in species differentiation.
Published New antibiotic approach proves promising against lyme bacterium
(via sciencedaily.com) Original source Using a technique that has shown promise in targeting cancer tumors, a team has found a way to deploy a molecular warhead that can annihilate the bacterium that causes Lyme disease.
Published Research outlines how sex differences have evolved
(via sciencedaily.com) Original source Researchers have shown that sex differences in animals vary dramatically across species, organs and developmental stages, and evolve quickly at the gene level but slowly at the cell type level.
Published Female sex determining gene identified in mice
(via sciencedaily.com) Original source Researchers have identified a gene which is an early determining factor of ovary development in mice.
Published A known environmental hazard can change the epigenetics of cells
(via sciencedaily.com) Original source An international team of researchers has discovered that formaldehyde, a widely spread pollutant and common metabolite in our body, interferes in the epigenetic programming of the cell. This finding expands the knowledge of formaldehyde, previously considered only as a DNA mutagen, and helps establishing a further link with cancer.
Published Observation of a virus attaching to another virus
(via sciencedaily.com) Original source 'Satellite' viruses must be in proximity to their 'helper' virus to replicate, but this research reports the first documented case of a satellite virus attaching itself to its helper virus. Out of 50 observed helpers, 40 had a satellite bound. Bioinformatic analysis of the satellite and helper viruses' genomes provides clues as to why the satellite may have evolved to attach to the helper, and suggests this pair may have been co-evolving for about 100 million years.
Published Immunology: Dysfunction of mitochondria drives the exhaustion of T cells
(via sciencedaily.com) Original source In the immune system's fight against cancer and infections, the T cells often lose their power. Now immunologists may have found a possible explanation for this phenomenon.
Published Researchers engineer colloidal quasicrystals using DNA-modified building blocks
(via sciencedaily.com) Original source A new study unveils a novel methodology to engineer colloidal quasicrystals using DNA-modified building blocks. The implications of this breakthrough are far-reaching, offering a potential blueprint for the controlled synthesis of other complex structures previously considered beyond reach.
Published First mice engineered to survive COVID-19 like young, healthy humans
(via sciencedaily.com) Original source Researchers have genetically engineered the first mice that get a human-like form of COVID-19, according to a new study.
Published Where is a sea star's head? Maybe just about everywhere
(via sciencedaily.com) Original source A new study that combines genetic and molecular techniques helps solve the riddle of sea star (commonly called starfish) body plans, and how sea stars start life with bilateral body symmetry -- just like humans -- but grow up to be adults with fivefold 'pentaradial' symmetry.
Published The ringed seals in Ilulissat Icefjord, Greenland are special
(via sciencedaily.com) Original source Local hunters in the Icefjord near Ilulissat have long known about a special ringed seal -- the Kangia seal -- which is significantly larger and has a markedly different fur color and pattern than typical Arctic ringed seals. Now scientific studies have shown that the Kangia ringed seal has been isolated from other ringed seals for a long period of time -- more than 100,000 years.
Published Pinpointing HIV immune response
(via sciencedaily.com) Original source New research combining computer modeling and experiments with macaques shows the body's immune system helps control human immunodeficiency virus (HIV) infections largely by suppressing viral production in already infected cells while also killing viral infected cells, but only within a narrow time window at the start of a cell's infection.
Published Maternal microbiota can affect fetal development
(via sciencedaily.com) Original source Significant differences in the gene activity of the fetal intestine, brain and placenta were identified, depending on the microbes in the mother's body and the compounds produced by them. The findings indicate that maternal microbes are important to her offspring's development and health.