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Categories: Biology: Biotechnology, Geoscience: Volcanoes
Published Researchers develop DANGER analysis tool for the safer design of gene editing
(via sciencedaily.com) Original source A team of researchers has developed a software tool that provides a way for the safer design of genome editing in all organisms with a transcriptome. For about a decade, researchers have used the CRISPR technology for genome editing. However, there are some challenges in the use of CRISPR. The new analysis system overcomes these challenges and allows researchers to perform safer on- and off-target assessments without a reference genome. It holds the potential for applications in medicine, agriculture, and biological research.
Published Potential for injectable 'chemical vaccine' for malaria using atovaquone
(via sciencedaily.com) Original source Researchers looking to develop a long-acting, injectable malaria preventive using atovaquone have shown in a new study that resistance may not be the challenge scientists thought it was, particularly when using atovaquone as a malaria preventive. Malaria parasites in infected patients being treated with atovaquone tend to develop a resistance to the drug. Because of this, atovaquone by itself is not used as a malaria treatment nor has not been seen as a strong candidate for use as a preventive.
Published Can golden retrievers live longer?
(via sciencedaily.com) Original source Researchers have found a gene associated with longevity in golden retrievers, one of the most popular breeds of dogs.
Published DNA shows where Washington culvert replacements helped spawning salmon
(via sciencedaily.com) Original source University and federal scientists used genetic sleuthing to study how salmon were affected by two major culvert replacements near the city of Bellingham. One project, a major upgrade under Interstate-5, had a big impact, while the other old culvert may have been less of a barrier to fish. Authors from the UW and NOAA are studying the use of environmental DNA, or eDNA, in future environmental impact reporting.
Published You say genome editing, I say natural mutation
(via sciencedaily.com) Original source A plant geneticist and computational biologist teamed up to decipher the unpredictability of natural and engineered mutations in tomatoes. They discovered some combinations of mutations behave as expected while others are more erratic. Their work may help scientists find some order in the chaos of evolution and genome editing.
Published Physical theory improves protein folding prediction
(via sciencedaily.com) Original source Proteins are important molecules that perform a variety of functions essential to life. To function properly, many proteins must fold into specific structures. However, the way proteins fold into specific structures is still largely unknown. Researchers have developed a novel physical theory that can accurately predict how proteins fold. Their model can predict things previous models cannot. Improved knowledge of protein folding could offer huge benefits to medical research, as well as to various industrial processes.
Published Restoring the function of a human cell surface protein in yeast cells
(via sciencedaily.com) Original source Yeast cells are widely used to study G protein-coupled receptors (GPCRs), a large group of cell surface proteins in humans. However, several of these proteins lose their function when introduced into yeast cells. To tackle this issue, researchers developed an innovative strategy to restore GPCR function in yeast cells by inducing random mutations. Their findings can help understand GPCRs better and could pave the way to therapeutic breakthroughs for many diseases.
Published Stolen genes allow parasitic control of behavior
(via sciencedaily.com) Original source A research team has discovered that parasites manipulate their hosts using stolen genes that they likely acquired through a phenomenon called horizontal gene transfer.
Published New 'subway map' of Lyme disease pathways identifies potential new treatment targets
(via sciencedaily.com) Original source Scientists have developed a genome-scale metabolic model or 'subway map' of key metabolic activities of the bacterium that causes Lyme disease. Using this map, they have successfully identified two compounds that selectively target routes only used by Lyme disease to infect a host.
Published Soft optical fibers block pain while moving and stretching with the body
(via sciencedaily.com) Original source New soft, implantable fibers can deliver light to major nerves through the body. They are an experimental tool for scientists to explore the causes and potential treatments for peripheral nerve disorders in animal models.
Published California supervolcano is cooling off but may still cause quakes
(via sciencedaily.com) Original source New high-resolution images of the Long Valley Caldera indicate that the subsurface environment is cooling off, releasing gas and fluids that contribute to seismic activity.
Published Yeast speeds discovery of medicinal compounds in plants
(via sciencedaily.com) Original source Researchers have harnessed the power of baker's yeast to create a cost-effective and highly efficient approach for unraveling how plants synthesize medicinal compounds, and used the new method to identify key enzymes in a kratom tree.
Published Scientists uncover new way viruses fight back against bacteria
(via sciencedaily.com) Original source A microscopic discovery will not only enable scientists to understand the microbial world around us but could also provide a new way to control CRISPR-Cas biotechnologies.
Published Unlocking the secrets of cell behavior on soft substrates: A paradigm shift in mechanobiology
(via sciencedaily.com) Original source A research group has developed a new method for studying how cancer cells function in softer and stiffer tissue environments. This insight challenges the existing paradigm, opening up new possibilities for research in cancer biology and tissue engineering.
Published Whaling wiped out far more fin whales than previously thought
(via sciencedaily.com) Original source Whaling in the 20th century destroyed 99% of the Eastern North Pacific fin whale breeding population. Because there is enough genetic diversity, current conservation measures should help the population rebound without becoming inbred. The future of fin whales in the Gulf of California depends on the recovery of the Eastern North Pacific population.
Published Art with DNA -- Digitally creating 16 million colors by chemistry
(via sciencedaily.com) Original source The DNA double helix is composed of two DNA molecules whose sequences are complementary to each other. The stability of the duplex can be fine-tuned in the lab by controlling the amount and location of imperfect complementary sequences. Fluorescent markers bound to one of the matching DNA strands make the duplex visible, and fluorescence intensity increases with increasing duplex stability. Now, researchers have succeeded in creating fluorescent duplexes that can generate any of 16 million colors -- a work that surpasses the previous 256 colors limitation. This very large palette can be used to 'paint' with DNA and to accurately reproduce any digital image on a miniature 2D surface with 24-bit color depth.
Published Unlocking secrets of immune system proteins: A potential path to new treatments
(via sciencedaily.com) Original source Using cryo-electron microscopy (cryo-EM), researchers captured unprecedented images of key immune system receptors interacting with messenger proteins, elucidating how the receptors change shape upon activation and transmit signals within the cell. The findings suggest new pathways for developing therapeutic molecules for diseases such as COVID-19, rheumatoid arthritis, neurodegenerative diseases and cancer.
Published Scientists discover the possible triggers for bacterial pathogens, opening the door for new treatment strategies
(via sciencedaily.com) Original source The legendary Alexander Fleming, who famously discovered penicillin, once said 'never to neglect an extraordinary appearance or happening.' And the path of science often leads to just that. New research is turning the page in our understanding of harmful bacteria and how they turn on certain genes, causing disease in our bodies.
Published Genomic analysis in snakes shows link between neutral, functional genetic diversity
(via sciencedaily.com) Original source In the world of threatened and endangered species conservation, the genomic revolution has raised some complicated questions: How can scientists justify assessing species genetic diversity without consulting entire genomes now that they can be sequenced? But then again, how can scientists justify the time and expense of genome sequencing when age-old measures of neutral genetic diversity are much cheaper and easier to obtain? A new study suggests making a transition from 'old school' genetics to 'new school' genomics for species conservation purposes probably isn't necessary in all cases.
Published Fungal infection in the brain produces changes like those seen in Alzheimer's disease
(via sciencedaily.com) Original source Researchers have discovered how the fungus Candida albicans enters the brain, activates two separate mechanisms in brain cells that promote its clearance, and, important for the understanding of Alzheimer's disease development, generates amyloid beta (Ab)-like peptides, toxic protein fragments from the amyloid precursor protein that are considered to be at the center of the development of Alzheimer's disease.