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Categories: Biology: Biotechnology, Geoscience: Earthquakes
Published Yeast cells can produce drugs for treatment of psychotic disorders
(via sciencedaily.com) Original source An international team of researchers has demonstrated that genetically engineered yeast cells can produce the natural plant product alstonine, which has shown positive effects in treating schizophrenia.
Published Team creates synthetic enzymes to unravel molecular mysteries
(via sciencedaily.com) Original source A bioengineer has developed synthetic enzymes that can control the behavior of the signaling protein Vg1, which plays a key role in the development of muscle, bone and blood in vertebrate embryos. The team of researchers is using a new approach, called the Synthetic Processing (SynPro) system, in zebrafish to study how Vg1 is formed. By learning the molecular rules of signal formation in a developing animal, researchers aim to engineer mechanisms -- such as giving cells new instructions -- that could play a role in treating or preventing disease.
Published New way to count microbes speeds research, cuts waste, could lead to new antibiotics
(via sciencedaily.com) Original source Researchers have developed a new way of counting microorganisms that works as much as 36 times faster than conventional methods, cuts plastic use more than 15-fold and substantially decreases the cost and carbon footprint of biomedical research. The technique could revolutionize the way microbiology experiments are conducted, allowing researchers to test potential new antibiotics in a fraction of the time.
Published Scientists use quantum biology, AI to sharpen genome editing tool
(via sciencedaily.com) Original source Scientists used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.
Published A breath of fresh air keeps drug-producing cells alive longer
(via sciencedaily.com) Original source Researchers have developed a novel device that produces oxygen inside of a 'living pharmacy' implant in order to keep cells alive inside the self-contained device. The device produses oxygen through a smart, energy-efficient version of water splitting. In new experiments, the novel device kept cells (70-80%) alive for close to a month in low oxygen conditions in vitro, or weeks in vivo.
Published First live birth of a chimeric monkey using embryonic stem cell lines
(via sciencedaily.com) Original source A team of researchers has reported for the first time the live birth of a monkey that contains a high proportion of cells derived from a monkey stem cell line. This 'chimeric' monkey is composed of cells that originate from two genetically distinct embryos of the same species of monkey. This has previously been demonstrated in rats and mice but, until now, has not been possible in other species, including non-human primates.
Published Zen and the art of mitochondrial maintenance: The machinery of death makes a healthier life
(via sciencedaily.com) Original source While we all aspire for a long lifespan, what is most coveted is a long period of vigor and health, or 'healthspan,' that precedes the inevitable decline of advancing age. Researchers have discovered that instruments of death that cells use to commit suicide when things go wrong contribute to making a longer and healthier life by revitalizing the specialized cellular compartments called mitochondria.
Published Temperature increase triggers viral infection
(via sciencedaily.com) Original source Researchers have mapped on an atomic level what happens in a virus particle when the temperature is raised.
Published How animals get their stripes and spots
(via sciencedaily.com) Original source New research helps explain how sharp patterns form on zebras, leopards, tropical fish and other creatures. Their findings could inform the development of new high-tech materials and drugs.
Published Head lice evolution mirrors human migration and colonization in the Americas
(via sciencedaily.com) Original source A new analysis of lice genetic diversity suggests that lice came to the Americas twice -- once during the first wave of human migration across the Bering Strait, and again during European colonization.
Published Identifying a silicon transporter to improve the yield of rice
(via sciencedaily.com) Original source Researchers identify a membrane transporter in rice that regulates the accumulation and localization of silicon in the leaves.
Published Device 'smells' seawater to discover, detect novel molecules
(via sciencedaily.com) Original source Under the ocean's surface, marine organisms are constantly releasing invisible molecules. Some of the chemical clues reveal which creatures are nearby, while others could be used someday as medications. Now, researchers report a proof-of-concept device that 'sniffs' seawater, trapping dissolved compounds for analyses. The team showed that the system could easily concentrate molecules that are present in underwater caves and holds promise for drug discovery in fragile ecosystems, including coral reefs.
Published The metabolism of bacteria under the microscope: New method reveals host-microbe interactions
(via sciencedaily.com) Original source The fascinating world of bacteria that live as symbionts or parasites in animal hosts often remains a mystery to researchers. A research team has made a breakthrough that provides insights into this mysterious micro-world.
Published Yeast with an over half synthetic genome is created in the lab
(via sciencedaily.com) Original source Researchers have combined over seven synthetic chromosomes that were made in the lab into a single yeast cell, resulting in a strain with more than 50% synthetic DNA that survives and replicates similarly to wild yeast strains. A global consortium is working to develop the first synthetic eukaryote genome from scratch. The team has now synthesized and debugged all sixteen yeast chromosomes.
Published Scientists take major step towards completing the world's first synthetic yeast
(via sciencedaily.com) Original source A team of Scientists has completed construction of a synthetic chromosome as part of a major international project to build the world's first synthetic yeast genome. The work represents completion of one of the 16 chromosomes of the yeast genome, which is part of the biggest project ever in synthetic biology; the international synthetic yeast genome collaboration. The collaboration, known as 'Sc2.0' has been a 15-year project involving teams from around the world (UK, US, China, Singapore, UK, France and Australia), working together to make synthetic versions of all of yeast's chromosomes. Alongside this paper, another 9 publications are also released today from other teams describing their synthetic chromosomes. The final completion of the genome project -- the largest synthetic genome ever -- is expected next year.
Published New dates for landslides reveal past Seattle fault earthquakes
(via sciencedaily.com) Original source New maps of more than 1,000 deep-seated landslides in the Puget Lowlands of Washington State provide evidence of the last major earthquake along the Seattle Fault about 1,100 years ago -- and may also hold traces of older earthquakes along the fault.
Published Cracking the code: Genome sequencing reveals why songbirds are larger in colder climates
(via sciencedaily.com) Original source Scientists have unlocked the genetic basis underlying the remarkable variation in body size observed in song sparrows, one of North America's most familiar and beloved songbirds. This discovery also provides insights into this species' capacity to adapt to the challenges of climate change. The study used genomic sequencing to successfully pinpoint eight genetic variants, or DNA mutations, largely responsible for the nearly threefold difference in body size observed across the song sparrow range from Mexico to Alaska.
Published 'Biodiversity time machine' provides insights into a century of loss
(via sciencedaily.com) Original source AI analysis shows pollution levels, extreme weather events and increasing temperatures devastates biodiversity in freshwater lakes.
Published 450-million-year-old organism finds new life in Softbotics
(via sciencedaily.com) Original source Researchers have used fossil evidence to engineer a soft robotic replica of pleurocystitids, a marine organism that existed nearly 450 million years ago and is believed to be one of the first echinoderms capable of movement using a muscular stem.
Published Plants' ingenious defense against mutational damage
(via sciencedaily.com) Original source How do plants deal with mutations in their 'power stations'? By exploiting randomness to create diversity, say researchers.