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Categories: Biology: Biotechnology, Geoscience: Earthquakes
Published Scientists unveil detailed cell maps of the human brain and the nonhuman primate brain
(via sciencedaily.com) Original source A group of international scientists have mapped the genetic, cellular, and structural makeup of the human brain and the nonhuman primate brain. This understanding of brain structure allows for a deeper knowledge of the cellular basis of brain function and dysfunction, helping pave the way for a new generation of precision therapeutics for people with mental disorders and other disorders of the brain.
Published Engineered bacteria paint targets on tumors for cancer-killing T cells to see
(via sciencedaily.com) Original source Synthetic biologists report on a new approach to attacking tumors. They have engineered tumor-colonizing bacteria (probiotics) to produce synthetic targets in tumors that direct CAR-T cells to destroy the newly highlighted cancer cells.
Published Win-win in muscle research: Faster results and fewer laboratory animals thanks to new method
(via sciencedaily.com) Original source To study muscle diseases, scientists rely on the mouse as a model organism. Researchers have now developed a new method that is not only faster and more efficient than conventional ones but also greatly reduces the number of experimental animals needed for studying the function of genes in muscle fibers.
Published Omega-3 discovery moves us closer to 'precision nutrition' for better health
(via sciencedaily.com) Original source Researchers have obtained new insights into how African-American and Hispanic-American people’s genes influence their ability to use Omega-3 and Omega-6 fatty acids for good health. The findings are an important step toward “precision nutrition” – where a diet tailored to exactly what our bodies need can help us live longer, healthier lives.
Published Mummified feces reveals pre-Columbian cultures of the Caribbean consumed a diversity of plants
(via sciencedaily.com) Original source DNA analysis of mummified feces reveals two pre-Columbian Caribbean cultures ate a wide variety of plants, like maize, sweet potato, and peanuts -- and tobacco and cotton traces were detected too, according to a new study.
Published Evolutionary secrets of 'Old Tom' and the killer whales of Eden revealed by genetic study
(via sciencedaily.com) Original source Evolutionary biologists have for the first time decoded the genetic lineage of a famous killer whale and a pod that once worked alongside whale hunters off the coast of Australia. In the Australian tradition of claiming New Zealand's celebrities as its own, Old Tom, the leader of a pod of killer whales that famously helped whalers hunt baleen whales in the 20th century, has ancestral links to modern-day killer whales in New Zealand, according to new DNA research. Old Tom also shared a common ancestor with killer whales from Australasia, the North Pacific, and North Atlantic Oceans, but is most similar to modern New Zealand killer whales. However, most of Tom's DNA code is not found in other killer whales globally suggesting that the killer whales of Eden may have become extinct locally.
Published Predator-prey defense mechanisms unlock key to marine biofuel production
(via sciencedaily.com) Original source Researchers have unpicked the mechanism behind a marine feeding strategy that could provide a valuable renewable source of biofuel.
Published Plate tectonic surprise: Geologist unexpectedly finds remnants of a lost mega-plate
(via sciencedaily.com) Original source Geologists have reconstructed a massive and previously unknown tectonic plate that was once one-quarter the size of the Pacific Ocean. The team had predicted its existence over 10 years ago based on fragments of old tectonic plates found deep in the Earth’s mantle. To the lead researchers surprise, she found that oceanic remnants on northern Borneo must have belonged to the long-suspected plate, which scientists have named Pontus. She has now reconstructed the entire plate in its full glory.
Published Newfound mechanism suggests drug combination could starve pancreatic cancer
(via sciencedaily.com) Original source A study found that a new combination of treatments safely decreased growth of pancreatic cancer in mice by preventing cancer cells from scavenging for fuel.
Published Epigenetic regulator MOF drives mitochondrial metabolism
(via sciencedaily.com) Original source Researchers have unveiled a new mechanism for regulating mitochondrial function. The findings reveal the critical role played by the enzymatic activity of the lysine acetyltransferase MOF in maintaining mitochondrial integrity and function through acetylation of mitochondrial electron transport chain component COX17. Cells lacking MOF-mediated COX17 acetylation exhibit dramatic mitochondrial defects and impaired ability to produce energy. Underscoring the clinical relevance of these findings, the team also showed that cells from human patients with a developmental disorder caused by mutations in MOF also exhibited respiratory defects that could be ameliorated by interventions such as acetylation-mimetic COX17 or mitochondrially targeted MOF.
Published How male mosquitoes compensate for having only one X chromosome
(via sciencedaily.com) Researchers have discovered the master regulator responsible for balancing the expression of X chromosome genes between males and females in the malaria mosquito. This discovery helps scientists better understand the evolution of the epigenetic mechanisms responsible for equalizing gene expression between the sexes. The findings may contribute to the development of new ways to prevent the spread of malaria.
Published Natural GM crops: Grasses take evolutionary shortcut by borrowing genes from their neighbors
(via sciencedaily.com) Original source Grass may transfer genes from their neighbors in the same way genetically modified crops are made, a new study has revealed.
Published New discovery may 'unlock' the future of infectious disease and cancer treatment
(via sciencedaily.com) Original source Researchers have identified a 'guard mechanism' for a protein which attacks microbes in infected cells, opening the possibility of new treatments for Toxoplasma, Chlamydia, Tuberculosis and even cancer.
Published The end of genes: Routine test reveals unique divergence in genetic code
(via sciencedaily.com) Original source Scientists testing a new method of sequencing single cells have unexpectedly changed our understanding of the rules of genetics. The genome of a protist has revealed a seemingly unique divergence in the DNA code signalling the end of a gene, suggesting the need for further research to better understand this group of diverse organisms.
Published AI-driven earthquake forecasting shows promise in trials
(via sciencedaily.com) Original source A new attempt to predict earthquakes has raised hopes that artificial intelligence could one day be used to limit earthquakes’ impact on lives and economies. The AI algorithm correctly predicted 70% of earthquakes a week before they happened during a seven-month trial in China. The system is limited because the AI needs an extensive database and years of seismic recordings to train itself on, but researchers said the effort is nonetheless a milestone for AI-driven earthquake forecasting. Researchers will soon begin testing the system at other locations.
Published New open-source method to improve decoding of single-cell data
(via sciencedaily.com) Original source Researchers have developed a new open-source computational method, dubbed Spectra, which improves the analysis of single-cell transcriptomic data. By guiding data analysis in a unique way, Spectra can offer new insights into the complex interplay between cells — like the interactions between cancer cells and immune cells, which are critical to improving immunotherapy treatments.
Published Ruffed grouse population more resilient than expected, genetic study finds
(via sciencedaily.com) Original source Despite decades of decline, a genetic analysis of ruffed grouse reveals that Pennsylvania's state bird harbors more genetic diversity and connectivity than expected. The findings suggest that the iconic game bird could be maintained in persistent numbers if appropriate protections are implemented.
Published Proteins roll the dice to determine bee sex
(via sciencedaily.com) Original source To date it has been unclear exactly how the sex of a bee is determined. A research team comprising biologists and chemists has now identified a key gene and the molecular mechanism linked with it. They describe how this process is similar to a game involving two dice.
Published Avatars to help tailor glioblastoma therapies
(via sciencedaily.com) Original source Scientists have created a new zebrafish xenograft platform to screen for novel treatments for an aggressive brain tumor called glioblastoma, according to a new study.
Published Discovery of massive undersea water reservoir could explain New Zealand's mysterious slow earthquakes
(via sciencedaily.com) Original source Researchers working to image New Zealand's Hikurangi earthquake fault have uncovered a sea's worth of water buried in the Earth's crust. The water was carried down by eroding volcanic rocks and is believed to be dampening the earthquake fault, allowing it to release most of the pent-up tectonic stress through harmless slow slip earthquakes.