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Categories: Biology: Biotechnology, Geoscience: Severe Weather
Published New discovery shows how cells defend themselves during stressful situations
(via sciencedaily.com) Original source A recent study has unveiled an exciting discovery about how our cells defend themselves during stressful situations. The research shows that a tiny modification in the genetic material, called ac4C, acts as a crucial defender, helping cells create protective storage units known as stress granules. These stress granules safeguard important genetic instructions when the cell is facing challenges. The new findings could help shed light on relevant molecular pathways that could be targeted in disease.
Published Microbial comics: RNA as a common language, presented in extracellular speech-bubbles
(via sciencedaily.com) Original source Decoding the conversations between microbes of hypersaline environments reveals deep insights into the origins of complex life.
Published Human stem cells coaxed to mimic the very early central nervous system
(via sciencedaily.com) Original source The first stem cell culture method that produces a full model of the early stages of the human central nervous system has been developed by a team of engineers and biologists.
Published Cutting-edge 'protein lawnmower' created
(via sciencedaily.com) Original source Scientists have designed the first synthetic protein-based motor which harnesses biological reactions to fuel and propel itself. 'Imagine if a Roomba could be powered only by the dirt it picks up,' says one of the authors of the study. The motor uses the digestive enzyme trypsin to cut the peptides and convert them into the energy it needs to propel itself.
Published Blindness from some inherited eye diseases may be caused by gut bacteria
(via sciencedaily.com) Original source Sight loss in certain inherited eye diseases may be caused by gut bacteria, and is potentially treatable by antimicrobials, finds a new study in mice.
Published The small intestine adapt its size according to nutrient intake
(via sciencedaily.com) Original source Resizing of the intestine is a highly conserved strategy employed by a wide range of organisms to cope with fluctuation in nutrient availability. Nevertheless, very little is known about the mechanisms and signals underlying nutrient-mediated gut resizing. New research has identified one of the signaling pathways implicated in this process.
Published Cloud clustering causes more extreme rain
(via sciencedaily.com) Original source Understanding cloud patterns in our changing climate is essential to making accurate predictions about their impact on society and nature. Scientists published a new study that uses a high-resolution global climate model to understand how the clustering of clouds and storms impacts rainfall extremes in the tropics. They show that with rising temperatures, the severity of extreme precipitation events increases.
Published Biomolecular condensates -- regulatory hubs for plant iron supply
(via sciencedaily.com) Original source Iron is a micronutrient for plants. Biologists now show that regulatory proteins for iron uptake behave particularly dynamically in the cell nucleus when the cells are exposed to blue light -- an important signal for plant growth. They found that the initially homogeneously distributed proteins relocated together into 'biomolecular condensates' in the cell nucleus shortly after this exposure.
Published Ribosomes: Molecular wedge assists recycling
(via sciencedaily.com) Original source Researchers reveal how cells regenerate protein factories at endoplasmic reticulum.
Published Compound vital for all life likely played a role in life's origin
(via sciencedaily.com) Original source A chemical compound essential to all living things has been synthesized in a lab in conditions that could have occurred on early Earth, suggesting it played a role at the outset of life.
Published Copies of antibiotic resistance genes greatly elevated in humans and livestock
(via sciencedaily.com) Original source Researchers have uncovered a key link between the spread of antibiotic resistance genes and the evolution of resistance to new drugs in certain pathogens. Bacteria exposed to higher levels of antibiotics often harbor multiple identical copies of protective antibiotic resistance genes which are linked to 'jumping genes' that can move from strain to strain. Duplicate genes provide a mechanism for resistance to spread and enable evolving resistance to new drugs.
Published Air pollution hides increases in rainfall
(via sciencedaily.com) Original source In a new study, researchers broke down how human-induced greenhouse gas and aerosol emissions influence rainfall in the United States. Greenhouse gas emissions increase rainfall, while aerosols have a long-term drying effect as well as short-term impacts that vary with the seasons. As aerosols decrease, their long-term drying effect will likely diminish, causing rainfall averages and extremes to rapidly increase.
Published Damage to cell membranes causes cell aging
(via sciencedaily.com) Original source Researchers have discovered that damage to the cell membrane promotes cellular senescence, or cell aging.
Published Stronger storms free more nutrients from mud flats
(via sciencedaily.com) Original source If storms become stronger in the future due to climate change, more nitrogen may be released from the bottom of coastal seas.
Published Scientists discover link between leaky gut and accelerated biological aging
(via sciencedaily.com) Original source A professor has demonstrated a connection between viral damage to the gut and premature biological aging.
Published An awkward family reunion: Sea monsters are our cousins
(via sciencedaily.com) Original source The sea lamprey, a 500-million-year-old animal with a sharp-toothed suction cup for a mouth, is the thing of nightmares. A new study discovered that the hindbrain -- the part of the brain controlling vital functions like blood pressure and heart rate -- of both sea lampreys and humans is built using an extraordinarily similar molecular and genetic toolkit.
Published Compounds in female ginseng could lead to new osteoporosis treatments
(via sciencedaily.com) Original source With ever-increasing life expectancy comes the challenge of treating age-related disorders such as osteoporosis. Although there are effective drugs for treating this metabolic bone disease, they can be expensive and have side effects, limiting their availability to some people. In the search for alternative drug candidates, researchers have discovered and fully replicated a compound from a botanical source, female ginseng, that had potent anti-osteoporotic activity in cellular tests.
Published New system triggers cellular waste disposal
(via sciencedaily.com) Original source Established treatments for cancer and other diseases often focus on inhibiting harmful enzymes to mitigate their effects. However, a more innovative approach has emerged: harnessing the cell's natural waste disposal system not just to deactivate but to entirely eradicate these proteins. Researchers have previously demonstrated the efficacy of this approach through two distinct methods. Now they unveil a third system capable of targeting and disposing of previously inaccessible proteins.
Published Detecting pathogens faster and more accurately by melting DNA
(via sciencedaily.com) Original source A new analysis method can detect pathogens in blood samples faster and more accurately than blood cultures, which are the current state of the art for infection diagnosis. The new method, called digital DNA melting analysis, can produce results in under six hours, whereas culture typically requires 15 hours to several days, depending on the pathogen.
Published Breakthrough in developing the PD-1-enhanced DNA vaccine for over 6-year cART-free AIDS prevention and virologic control
(via sciencedaily.com) Original source Researchers found that PD-1-enhanced DNA vaccination can induce sustained virus-specific CD8+ T cell immunity in an AIDS monkey model. The vaccinated monkeys remained free of AIDS for six years and achieved virologic control without the need for combination antiretroviral therapy (cART), a treatment used to suppress viral replication in individuals living with human immunodeficiency virus (HIV). The study also found that polyfunctional and broadly reactive effector-memory virus-specific T cells were maintained in the protected experimental macaques for over six years. The findings provide supporting evidence that the PD-1-enhanced DNA vaccine strategy holds promise as a third-generation DNA vaccine for AIDS prevention and immunotherapy.