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Categories: Biology: Biotechnology, Geoscience: Severe Weather
Published New trial highlights incremental progress towards a cure for HIV-1
(via sciencedaily.com) Original source A new clinical trial suggests that a combination of the drug vorinostat and immunotherapy can coax HIV-infected cells out of latency and attack them. The findings highlight how close -- yet still far -- researchers have come to developing a cure for HIV-1.
Published Sandalwood oil by-product prevents prostate cancer development in mice
(via sciencedaily.com) Original source Sandalwood oil has been used worldwide for centuries. Now, a study is the first to demonstrate in vivo the chemo-preventive properties of a by-product of the oil in a mouse model. Results show administering alpha-santalol reduced visible prostate tumors, protected the normal tissue, and delayed progression from a precancerous condition to a high-grade form of cancer. These findings are significant because mortality in prostate cancer patients is mainly attributable to advanced stages of the disease.
Published Nutrients direct intestinal stem cell function and affect aging
(via sciencedaily.com) Original source The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon aging. Researchers have discovered a new mechanism of action between the nutrient adaptation of intestinal stem cells and aging. The finding may make a difference when seeking ways to maintain the functional capacity of the aging gut.
Published 3D ice printing can create artificial blood vessels in engineered tissue
(via sciencedaily.com) Original source A new 3D printing method uses ice to build a template for artificial blood vessels in engineered tissue. Researchers hope the vessels could eventually be used in artificial organ transplants or drug testing.
Published How ancient sea creatures can inform soft robotics
(via sciencedaily.com) Original source Fossils of a marine animal that lived 500 million years ago, combined with computer simulations, informed the design of a new soft robot.
Published Researchers discover new cell that remembers allergies
(via sciencedaily.com) Original source Researchers have made a groundbreaking discovery: a new cell that remembers allergies.
Published New research uncovers biological drivers of heart disease risk
(via sciencedaily.com) Original source Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers combined multiple sequencing and experimental techniques to map the relationship between known CAD variants and the biological pathways they impact.
Published New approach to tackling bacterial infections identified
(via sciencedaily.com) Original source Researchers have identified a new approach to controlling bacterial infections. The team found a way to turn on a vital bacterial defense mechanism to fight and manage bacterial infections. The defense system, called cyclic oligonucleotide-based antiphage signaling system (CBASS), is a natural mechanism used by certain bacteria to protect themselves from viral attacks. Bacteria self-destruct as a means to prevent the spread of virus to other bacterial cells in the population.
Published Researchers discover key to molecular mystery of how plants respond to changing conditions
(via sciencedaily.com) Original source A team of researchers recently published a pioneering study that answers a central question in biology: how do organisms rally a wide range of cellular processes when they encounter a change -- either internally or in the external environment -- to thrive in good times or survive the bad times? The research, focused on plants, identifies the interactions between four compounds: pectin, receptor proteins FERONIA and LLG1 and the signal RALF peptide.
Published New study points to more climate extremes
(via sciencedaily.com) Original source A new study has found similarities between long-term climatic changes in South Australia and temperate agricultural areas in Argentina -- highlighting similarities across these Southern Hemisphere countries. As temperature records tumble, and the threat of bushfires and dry conditions looms large, researchers renew the urgency of calls to make more concerted efforts to prepare for climate extremes in South Australia.
Published Scientists develop new biocontainment method for industrial organisms
(via sciencedaily.com) Original source Researchers have developed a new biocontainment method for limiting the escape of genetically engineered organisms used in industrial processes.
Published Extra fingers and hearts: Pinpointing changes to our genetic instructions that disrupt development
(via sciencedaily.com) Original source Scientists can now predict which single-letter changes to the DNA within our genomes will alter genetic instructions and disrupt development, leading to changes such as the growth of extra digits and hearts. Such knowledge opens the door to predictions of which enhancer variants underlie disease in order to harness the full potential of our genomes for better human health.
Published Down to the core of poxviruses
(via sciencedaily.com) Original source A recent re-emergence and outbreak of Mpox brought poxviruses back as a public health threat, underlining an important knowledge gap at their core. Now, a team of researchers lifted the mysteries of poxviral core architecture by combining various cryo-electron microscopy techniques with molecular modeling.
Published Computer-engineered DNA to study cell identities
(via sciencedaily.com) Original source A new computer program allows scientists to design synthetic DNA segments that indicate, in real time, the state of cells. It will be used to screen for anti-cancer or viral infections drugs, or to improve gene and cell-based immunotherapies.
Published Microbial division of labor produces higher biofuel yields
(via sciencedaily.com) Original source Scientists have found a way to boost ethanol production via yeast fermentation, a standard method for converting plant sugars into biofuels. Their approach relies on careful timing and a tight division of labor among synthetic yeast strains to yield more ethanol per unit of plant sugars than previous approaches have achieved.
Published New technology unscrambles the chatter of microbes
(via sciencedaily.com) Original source Researchers have developed a new search tool to that can match microbes to the metabolites they produce with no prior knowledge, an innovation that could transform our understanding of both human health and the environment.
Published In a warming world, climate scientists consider category 6 hurricanes
(via sciencedaily.com) Original source For more than 50 years, the National Hurricane Center has used the Saffir-Simpson Windscale to communicate the risk of property damage; it labels a hurricane on a scale from Category 1 (wind speeds between 74 -- 95 mph) to Category 5 (wind speeds of 158 mph or greater). But as increasing ocean temperatures contribute to ever more intense and destructive hurricanes, climate scientists wondered whether the open-ended Category 5 is sufficient to communicate the risk of hurricane damage in a warming climate.
Published Mechanism discovered that protects tissue after faulty gene expression
(via sciencedaily.com) Original source A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic approaches to treat diseases caused by faulty splicing.
Published Disrupted cellular function behind type 2 diabetes in obesity
(via sciencedaily.com) Original source Disrupted function of 'cleaning cells' in the body may help to explain why some people with obesity develop type 2 diabetes, while others do not. A study describes this newly discovered mechanism.
Published A clutch stretch goes a long way
(via sciencedaily.com) Original source New results reveal a new mode of force transmission in which dynamic molecular stretching bridges the extracellular matrix and flowing F-actin moving at different speeds. This discovery underscores the necessity of molecular elasticity and random coupling for sufficiently transmitting force. The findings also call for revising the role of molecular unfolding.