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Categories: Biology: Biotechnology, Geoscience: Landslides

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The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.

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Researchers see potential in educational settings for the newest official ChatGPT plugin, called Code Interpreter, they've found limitations for its use by scientists who work with biological data utilizing computational methods to prioritize targeted treatment for cancer and genetic disorders.

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A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression.

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Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.

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Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.

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In a groundbreaking endeavor, researchers have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse's lifespan. The research opens exciting possibilities for unlocking the secrets of aging and extending human lifespan.

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A discovery about how a common insect acquires a microbe that is essential for its growth may help in the control of an agricultural pest.

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Regulatory genes -- genes that control how other genes are used -- are responsible for 69% of the heritability of dairy cattle traits such as milk production and fertility, according to a new study. This contribution is 44% more than expected and much higher than previous studies of regulatory genes in humans. The findings, reported by a team of animal and human geneticists, could improve the efficiency of agricultural breeding programs. The study also helps solve the longstanding mystery of why mammalian genomes contain so much noncoding DNA.

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Terrestrial carbon sinks can mitigate the greenhouse effect. Researchers pooled various data sources and found that European carbon storage takes place mainly in surface biomass in East Europe. However, changes of land use in particular have caused this carbon sink to decline.

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As climate change progresses, rising temperatures may impact nitrogen runoff from land to lakes and streams more than projected increases in total and extreme precipitation for most of the continental United States, according to new research from a team of climate scientists.

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Researchers find large methane emissions: 'Do not flood low-lying areas with freshwater'. Their studies find that freshwater lakes emit much more methane than saltwater lagoons, bogs and wet meadows.

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Scientists once assumed that flooding and mudslides after wildfires were linked to the waxy coating that builds up on charred soil, preventing water absorption. Researchers found that water flow came from absorbed water in both burnt and unburnt areas, suggesting that water was, in fact, being absorbed into burnt ground. The discovery provides valuable insights into where and when potential flooding and mudslides may occur and how landscapes recover after a wildfire.

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A groundbreaking study reveals the critical yet severely understudied factor of salinity changes in ocean and coastlines caused by climate change.

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Many factors influence where a landslide will occur, including the shape of the terrain, its slope and drainage areas, the material properties of soil and bedrock, and environmental conditions like climate, rainfall, hydrology and ground motion resulting from earthquakes. Geologists have developed a new technique that uses artificial intelligence to better predict where and why landslides may occur could bolster efforts to protect lives and property in some of the world's most disaster-prone areas. The new method improves the accuracy and interpretability of AI-based machine-learning techniques, requires far less computing power and is more broadly applicable than traditional predictive models.

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A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies. Called the viral load, this is what is measured to allow clinicians to understand how patients are responding to anti-viral medications and monitor potential progression. The time-consuming viral load testing needs to be repeated several times as a patient undergoes treatment. Now, a research team has developed a time and cost-efficient digital assay that can directly measure the presence of HIV in single drop of blood.

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The Bachman's warbler, a songbird that was last seen in North America nearly 40 years ago, was a distinct species and not a hybrid of its two living sister species, according a new study in which the full genomes of seven museum specimens of the bird were sequenced.

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Researchers report that, in laboratory cultures and animal models, a drug significantly reduces the ability of bacteria to develop antibiotic resistance, which might prolong antibiotic effectiveness.

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Just as space holds infinite mysteries, when we zoom in at the level of biomolecules (one trillion times smaller than a meter), there is still so much to learn. Scientists are studying the conformational landscapes of biomolecules and how they modulate cell function. When biomolecules receive certain inputs, it can cause the atoms to rearrange and the biomolecule to change shape. This change in shape affects their function in cells, so understanding conformational dynamics is critical for drug development.

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Researchers have deciphered a biochemical mechanism that ensures that newly formed proteins are processed correctly when they leave the cell's own protein factories. This solves a decade-old puzzle in protein sorting.

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An obscure aquatic plant has helped to explain how plants avoid cracking up under the stresses and strains of growth.