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Published

Here's how a worm's embryonic cells changed its development potential      (via sciencedaily.com)     Original source 

Researchers have spotted how specific proteins within the chromosomes of roundworms enable their offspring to produce specialized cells generations later, a startling finding that upends classical thinking that hereditary information for cell differentiation is mostly ingrained within DNA and other genetic factors.

Anthropology: Early Humans Anthropology: General Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Evolutionary Biology: General Biology: Genetics Environmental: Ecosystems Paleontology: Early Mammals and Birds Paleontology: Fossils Paleontology: General
Published

Woolly mammoths evolved smaller ears and woolier coats over the 700,000 years that they roamed the Siberian steppes      (via sciencedaily.com)     Original source 

A team of researchers compared the genomes of woolly mammoths with modern day elephants to find out what made woolly mammoths unique, both as individuals and as a species. The investigators report that many of the woolly mammoth's trademark features -- including their woolly coats and large fat deposits -- were already genetically encoded in the earliest woolly mammoths, but these and other traits became more defined over the species' 700,000+ year existence. They also identified a gene with several mutations that may have been responsible for the woolly mammoth's miniscule ears.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Microbiology
Published

Simple but revolutionary modular organoids      (via sciencedaily.com)     Original source 

A team has developed an ingenious device, using layers of hydrogels in a cube-like structure, that allows researchers to construct complex 3D organoids without using elaborate techniques. The group also recently demonstrated the ability to use the device to build organoids that faithfully reproduce the asymmetric genetic expression that characterizes the actual development of organisms.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Researchers clear the way for well-rounded view of cellular defects      (via sciencedaily.com)     Original source 

New research investigates how cells divide, particularly in the fibrous environment of living tissue. Cells are typically studied in a flat environment, and the difference between flat and fibrous landscapes opens new windows into the behavior of cells and the diseases that impact them.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Broccoli consumption protects gut lining, reduces disease, in mice      (via sciencedaily.com)     Original source 

Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidence of cancer and type 2 diabetes. In a recent study, researchers found that broccoli contains certain molecules that bind to a receptor within mice and help to protect the lining of the small intestine, thereby inhibiting the development of disease. The findings lend support to the idea that broccoli truly is a 'superfood.'

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Evolutionary Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Blind dating in bacteria evolution      (via sciencedaily.com)     Original source 

A team of researchers reconstructed long-extinct proteins of a UV protection system of cyanobacteria. The surprising result: the proteins were already compatible with each other when they first met. This discovery expands the knowledge horizon on the rules of evolution.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Offbeat: General Offbeat: Plants and Animals
Published

Researchers create embryo-like structures from monkey embryonic stem cells      (via sciencedaily.com)     Original source 

Human embryo development and early organ formation remain largely unexplored due to ethical issues surrounding the use of embryos for research as well as limited availability of materials to study. Investigators now report on the creation of embryo-like structures from monkey embryonic stem cells. The investigators also transferred these embryo-like structures into the uteruses of female monkeys and determined that the structures were able to implant and elicit a hormonal response similar to pregnancy.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Molecular
Published

Activating adult-born neurons through deep brain stimulation alleviates Alzheimer's symptoms in rodent models      (via sciencedaily.com)     Original source 

People with Alzheimer's disease develop defects in cognitive functions like memory as well as problems with noncognitive functions that can lead to anxiety and depression. Investigators used mice to study a process through which new neurons are generated in adulthood, called adult hippocampus neurogenesis (AHN). The research showed that deep brain stimulation of new neurons helped restore both cognitive and noncognitive functions in mouse models of Alzheimer's disease.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Complex assembly process involved in DNA virus replication      (via sciencedaily.com)     Original source 

In a twist on the question, 'Which came first, the chicken or the egg?', scientists have long faced a similar question about how human adenovirus replicates: 'Which comes first, assembly of the viral particle, or packaging of the viral genome?' Now, in a new study, scientists have answered that question, showing that viral proteins use a process called phase separation to coordinate production of viral progeny.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Chemistry: Biochemistry Offbeat: General Offbeat: Plants and Animals
Published

A miniature heart in a petri dish: Organoid emulates development of the human heart      (via sciencedaily.com)     Original source 

A team has induced stem cells to emulate the development of the human heart. The result is a sort of 'mini-heart' known as an organoid. It will permit the study of the earliest development phase of our heart and facilitate research on diseases.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Study to decode microbe-gut signaling suggests potential new treatment for IBD      (via sciencedaily.com)     Original source 

Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Microbiology Biology: Zoology
Published

New research shows that bacteria get 'hangry,' too      (via sciencedaily.com)     Original source 

Researchers have discovered, using a recently developed technology, that genetically identical cells within a bacterial community have different functions, with some members behaving more docile and others producing the very toxins that make us feel ill.

Biology: Biochemistry Biology: Biotechnology Biology: Botany Biology: Cell Biology Biology: General Biology: Genetics Biology: Molecular Ecology: Endangered Species
Published

DELLA proteins could hold key to the next Green Revolution      (via sciencedaily.com)     Original source 

A family of 'promiscuous' proteins found in all land plants is responsible for many different plant functions, despite remaining relatively unchanged for over 450 million years.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Molecular Biology: Zoology
Published

Cold is beneficial for healthy aging, at least in animals      (via sciencedaily.com)     Original source 

A lower body temperature is one of the most effective mechanisms to prolong the lifespan of animals. New research has now described precisely how this works. The scientists show that cold can prevent the pathological aggregation of proteins typical for two aging-associated neurodegenerative diseases.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Environmental: General Geoscience: Environmental Issues Geoscience: Geochemistry
Published

Wastewater more potent breeding ground for antibiotic resistance than previously known      (via sciencedaily.com) 

Wastewater is a more potent environment for antibiotic resistance to evolve than previously known. A study shows that wastewaters have unique characteristics, allowing resistance genes to start their journey from harmless bacteria to those that cause disease.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Microbiology Chemistry: Biochemistry
Published

Engineered E. coli delivers therapeutic nanobodies to the gut      (via sciencedaily.com)     Original source 

Researchers have succeeded in developing an E. coli-based 'smart microbe' that secretes therapeutic payloads, including antibodies, into the gut. The genetically modified beneficial strain of bacteria blocks intestinal inflammation in a preclinical model of inflammatory bowel disease and has the potential to treat intestinal-based diseases.