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Categories: Biology: Biotechnology, Geoscience: Geology
Published Shining a new light on the tug-of-war between virus and host
(via sciencedaily.com) Original source The interplay between ribonucleic acid (RNA) and proteins is not only important for maintaining cellular homeostasis but is also at the center of the tug-of-war between virus and host. Until now, there has been no method to globally map direct interactions of individual RNA regions in an unbiased fashion without the need for genetic modification of the target RNA or cell. Researchers have now developed a breakthrough tool that overcomes this limitation.
Published Source rocks of the first real continents
(via sciencedaily.com) Original source Geoscientists have uncovered a missing link in the enigmatic story of how the continents developed- - a revised origin story that doesn't require the start of plate tectonics or any external factor to explain their formation. Instead, the findings rely solely on internal geological forces that occurred within oceanic plateaus that formed during the first few hundred million years of Earth's history.
Published Discovery of a third RNA virus linage in extreme environments Jan 17, 2024
(via sciencedaily.com) Original source A research group has discovered a novel RNA viral genome from microbes inhabiting a high-temperature acidic hot spring. Their study shows that RNA viruses can live in high-temperature environments (70-80 degrees Celsius), where no RNA viruses have been observed before. In addition to the two known RNA virus kingdoms, a third kingdom may exist.
Published Groundbreaking genome editing tools unlock new possibilities for precision medicine
(via sciencedaily.com) Original source A team of researchers has achieved a major breakthrough in genome editing technology. They've developed a cutting-edge method that combines the power of designer-recombinases with programmable DNA-binding domains to create precise and adaptable genome editing tools.
Published How seahorse-like toxins kill insects
(via sciencedaily.com) Original source Insect-killing bacteria typically release toxins to slay their hosts. The bacterium Photorhabdus luminescens, for example, pumps insect larvae full of the lethal 'Makes caterpillars floppy 1' (Mcf1) toxin, leading them to first become droopy and then dead. However, it has so far been a mystery how Mcf1 unfolds its devastating effect. Researchers successfully used cryo-electron microscopy (cryo-EM) and biochemical assays to characterize the first-ever Mcf1 structure, allowing them to propose a molecular mechanism of the toxin's action. Understanding how bacterial toxins perform their deadly task in such detail is very useful for engineering novel biopesticides, thereby reducing the use of barely specific chemical agents with harmful side effects for the ecosystem.
Published Engineering viruses to kill deadly pathogens
(via sciencedaily.com) Original source Antimicrobial resistance is an urgent and growing global crisis. Researchers are exploring phages, viruses that infect bacteria, as a possible solution. In the new study, researchers successfully modified DNA from four types of phages to kill a deadly pathogen. The process can also be used to produce more phage variants for further exploration.
Published Using computers to design proteins allows researchers to make tunable hydrogels that can form both inside and outside of cells
(via sciencedaily.com) Original source New research demonstrates a new class of hydrogels that can form not just outside cells, but also inside of them. These hydrogels exhibited similar mechanical properties both inside and outside of cells, providing researchers with a new tool to group proteins together inside of cells.
Published DNA particles that mimic viruses hold promise as vaccines
(via sciencedaily.com) Original source Using a DNA-based delivery particle, researchers created a vaccine that can induce a strong antibody response against SARS-CoV-2.
Published Asparagus and orchids are more similar than you think
(via sciencedaily.com) Original source How is a beech leaf constructed? What determines the appearance of an asparagus? A new 'encyclopaedia' helps us learn more about the building blocks of plants. The encyclopaedia, probably the largest of its kind, could be used to improve targeted plant breeding efforts, to make them both more climate-resilient and more easily digestible.
Published 'Genomic time machine' reveals secrets of our DNA
(via sciencedaily.com) Original source Researchers reveal a novel method to uncover bits of our genetic blueprint that come from ancient genetic parasites, offering fresh insights into human evolution and health.
Published A non-allergenic wheat protein for growing better cultivated meat
(via sciencedaily.com) Original source As the world's population increases, cultivated or lab-grown meat -- animal muscle and fat cells grown in laboratory conditions -- has emerged as a potential way to satisfy future protein needs. And edible, inexpensive plant proteins could be used to grow these cell cultures. Now, researchers report that the non-allergenic wheat protein glutenin successfully grew striated muscle layers and flat fat layers, which could be combined to produce meat-like textures.
Published Researchers map genome for cats, dolphins, birds, and dozens of other animals
(via sciencedaily.com) Original source Researchers mapped genetic blueprints for 51 species including cats, dolphins, kangaroos, penguins, sharks, and turtles, a discovery that deepens our understanding of evolution and the links between humans and animals. The researchers developed novel algorithms and computer software that cut the sequencing time from months -- or decades in the case of the human genome -- to a matter of days.
Published How macrophages regulate regenerative healing in spiny mice
(via sciencedaily.com) Original source A team of researchers is delving deeper into the science behind how spiny mice can regenerate lost tissue and using what they learn to trigger regeneration in other types of mice -- advances which one day may be translated into humans. Whereas adult laboratory mice heal injuries with scar tissue, spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body.
Published Unexpected biodiversity on the ocean floor
(via sciencedaily.com) Original source Hydrothermal vents and manganese nodule fields in the deep oceans contain more biodiversity than expected.
Published How does HIV get into the cell's cenetr to kickstart infection?
(via sciencedaily.com) Original source UNSW Sydney medical scientists have cracked a mystery whose solution has long eluded researchers. UNSW Sydney medical scientists have cracked a mystery whose solution has long eluded researchers.
Published DNA from preserved feces reveals ancient Japanese gut environment
(via sciencedaily.com) Original source DNA from ancient feces can offer archaeologists new clues about the life and health of Japanese people who lived thousands of years ago, according to a new study.
Published Sparrows uniquely adapted to Bay Area marshes are losing their uniqueness
(via sciencedaily.com) Original source How does loss of habitat affect the animals still living there? A genetic study of saltwater-adapted Savannah sparrows around the San Francisco Bay Area shows that the 90% loss of tidal marsh habitat has led to more interbreeding with freshwater-adapted Savannah sparrows, diminishing their genetic adaptation to saltwater, such as enlarged kidneys and larger beak. This could lessen their ability to live in a saltwater habitat.
Published Innovative microscopy technique reveals secrets of lipid synthesis inside cells
(via sciencedaily.com) Original source Researchers have made a pivotal discovery in the field of cellular microscopy. The team has successfully developed Two-Color Infrared Photothermal Microscopy (2C-IPM), a novel technology designed to investigate neutral lipids within lipid droplets of living cells. This new microscopy can be used with isotope labeling, which allows for the detailed monitoring of neutral lipid synthesis within individual lipid droplets.
Published New tool reveals gene behavior in bacteria
(via sciencedaily.com) Original source Researchers showed that the way in which genes are turned on and off as bacteria grow provide clues to their regulation.
Published Syphilis-like diseases were widespread in Americas before arrival of Columbus, researchers find
(via sciencedaily.com) Original source Researchers have discovered the genetic material of the pathogen Treponema pallidum in the bones of people who died in Brazil 2,000 years ago. This is the oldest verified discovery of this pathogen thus far, and it proves that humans were suffering from diseases akin to syphilis -- known as treponematoses -- long before Columbus's discovery of America. The new findings call into question previous theories concerning the spread of syphilis by the Spanish conquistadors.