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Categories: Biology: Biotechnology, Geoscience: Oceanography
Published Spider silk is spun by silkworms for the first time, offering a green alternative to synthetic fibers
(via sciencedaily.com) Scientists have synthesized spider silk from genetically modified silkworms, producing fibers six times tougher than the Kevlar used in bulletproof vests. The study is the first to successfully produce full-length spider silk proteins using silkworms. The findings demonstrate a technique that could be used to manufacture an environmentally friendly alternative to synthetic commercial fibers such as nylon.
Published Fast-track strain engineering for speedy biomanufacturing
(via sciencedaily.com) Using engineered microbes as microscopic factories has given the world steady sources of life-saving drugs, revolutionized the food industry, and allowed us to make sustainable versions of valuable chemicals previously made from petroleum. But behind each biomanufactured product on the market today is the investment of years of work and many millions of dollars in research and development funding. Scientists want to help the burgeoning industry reach new heights by accelerating and streamlining the process of engineering microbes to produce important compounds with commercial-ready efficiency.
Published Tiny sea creatures reveal the ancient origins of neurons
(via sciencedaily.com) Original source A new study sheds new light on the origins of modern brain cells. Researchers find evidence that specialized secretory cells found in placozoans, tiny sea creatures the size of a grain of sand, have many similarities to the neuron, such as the genes required to create a partial synapse. From an evolutionary point of view, early neurons might have started as something like these cells, eventually gaining the ability to create a complete synapse, form axons and dendrites and create ion channels that generate fast electrical signals -- innovations which gave rise to the neuron in more complex animals such as jellyfish. Though the complete story of how the first neuron appeared remains to be told, the study demonstrates that the basic building blocks for our brain cells were forming in the ancestors of placozoans grazing inconspicuously in the shallow seas of Earth around 800 million years ago.
Published RNA for the first time recovered from an extinct species
(via sciencedaily.com) Original source A new study shows the isolation and sequencing of more than a century-old RNA molecules from a Tasmanian tiger specimen preserved at room temperature in a museum collection. This resulted in the reconstruction of skin and skeletal muscle transcriptomes from an extinct species for the first time. The researchers note that their findings have relevant implications for international efforts to resurrect extinct species, including both the Tasmanian tiger and the woolly mammoth, as well as for studying pandemic RNA viruses.
Published Tracking down the formation of cardenolides in plants
(via sciencedaily.com) Original source Scientists are investigating the previously largely unknown biosynthetic pathway that leads to the formation of cardenolides in plants. In a new study, they present two enzymes from the CYP87A family as key enzymes that catalyze the formation of pregnenolone, the precursor for the biosynthesis of plant steroids, in two different plant families. The discovery of such enzymes should help to develop platforms for the cheap and sustainable production of high quality steroid compounds for medical use.
Published Genome editing: Reducing off-target mutations in DNA
(via sciencedaily.com) Original source Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded 'nicks' in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.
Published Polar experiments reveal seasonal cycle in Antarctic sea ice algae
(via sciencedaily.com) Results provide the first measurements of how sea-ice algae and other single-celled life adjust to the dramatic seasonal rhythms in the Southern Ocean. The results provide clues to what might happen as this ecosystem shifts under climate change.
Published Genetically modified bacteria break down plastics in saltwater
(via sciencedaily.com) Original source Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans.
Published Specialized gut immune cells pinpointed that can limit progression of inflammatory bowel disease
(via sciencedaily.com) Original source Researchers have characterized a specialized type of immune cell, which plays a key role in protecting and repairing the cells in the healthy human gut.
Published Researchers discover tissue-specific protection against protein aggregation
(via sciencedaily.com) Original source Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail. By understanding how different tissues tackle protein build up, this research could accelerate the identification of ways to protect tissues that are vulnerable to protein build up, possibly tackling both disease-associated protein aggregates and also age-dependent aggregates that accelerate the functional decline of tissues.
Published Mysterious family of microbial proteins hijack crops' cellular plumbing
(via sciencedaily.com) Original source Some crop pathogens use a clever trick to multiply and spread infection: they hijack the plant's cellular plumbing. In a new study, researchers unveil a class of bacterial proteins that fold into a straw-like shape and insert themselves into the plant cell membrane, allowing the inside of the leaf to become waterlogged. The researchers also figured out a possible way to block the water channel proteins and prevent infection.
Published Scientists find good places to grow long-spined sea urchins, a starting point to restore 'the lawn mowers of the reefs'
(via sciencedaily.com) Scientists are trying to raise as many urchins as possible because they eat algae that could otherwise smother reef ecosystems and kill corals. Researchers have identified algae on which larval sea urchins grow into juveniles in a lab setting.
Published Natural compound found in plants inhibits deadly fungi
(via sciencedaily.com) Original source A new study finds that a natural compound found in many plants inhibits the growth of drug-resistant Candida fungi -- including its most virulent species, Candida auris, an emerging global health threat.
Published 100-year floods could occur yearly by end of 21st century
(via sciencedaily.com) Original source Most coastal communities will encounter '100-year floods' annually by the end of the century, even under a moderate scenario where carbon dioxide emissions peak by 2040, according to a new study. And as early as 2050, regions worldwide could experience 100-year floods every nine to fifteen years on average.
Published 'Dormant' HIV produces RNA and proteins during anti-retroviral therapy
(via sciencedaily.com) Original source HIV anti-retroviral therapy is considered a treatment and not a cure because patients usually carry a reservoir of HIV-infected cells that can re-emerge if treatment stops. These reservoirs have long been thought to be dormant, but two independent groups of researchers report that a subset of these cells spontaneously produce HIV RNA and proteins that may impact patients' HIV-specific immune responses.
Published Comprehensive insulin signalling map shows interplay between genes and diet
(via sciencedaily.com) Original source Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet.
Published New rivers in the North? Scientists identify how the dissection of Arctic landscapes is changing with accelerating climate change
(via sciencedaily.com) Original source New research shows that amplified global warming in the Canadian High Arctic drove a profound shift in the structure of a river network carved into a permafrost landscape in only 60 years.
Published Conservation in shark sanctuaries
(via sciencedaily.com) Original source Researchers are assessing the efficacy of shark sanctuaries by developing a modeling system that utilizes publicly accessible fishing data to determine shark catch and mortality rates. Their findings represent an important step in utilizing data science to tackle oceanic conservation challenges.
Published Super antifreeze in cells: The ability to survive in ice and snow developed in animals far earlier than we thought
(via sciencedaily.com) Original source More than 400 million years ago, an insect-like animal called the springtail developed a small protein that prevents its cells from freezing.
Published Researcher helps boost immune system memory against influenza
(via sciencedaily.com) Original source Researchers are one step closer to making the T cell army stronger. In a recent study, researchers found that by manipulating one molecular signaling pathway in the T cells that participate in clearing influenza virus in the lungs, the strength and longevity of immunological memory produced can be improved.